Does Cystatin C have a role as metabolic surrogate in peritoneal dialysis beyond its association with residual renal function?
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.16/2656 |
Resumo: | Introduction: It has been suggested that cystatin C levels are modified by obesity and inflammation. Furthermore, cystatin C has been associated with cardiovascular events and mortality outcomes. Aim: To study the association of cystatin C with the metabolic profile and cardiovascular disease of peritoneal dialysis patients. Methods: Data collected included clinical, laboratorial, and multifrequency bioimpedance assessment of 52 stable peritoneal dialysis patients. Minimal residual renal function was defined as > 2mL/min/1.73m2. Results: Serum cystatin C was not significantly associated with peritoneal or urinary cystatin C excretion. Negative correlation of cystatin C with normalized protein catabolic rate (rho -0.33, p = 0.02) and a trend towards positive correlation with relative body fat (rho 0.27, p = 0.05) were not independent from residual renal function. Cystatin C was not significantly associated with cardiovascular disease (p = 0.28), nor with glycated hemoglobin (p = 0.19) or c-reactive protein (p = 0.56). In the multivariate model, both age and diabetes were the strongest predictors of cardiovascular disease (odds ratio 1.09, p = 0.029 and odds ratio 29.95, p = 0.016, respectively), while relative body fat was negatively associated with cardiovascular disease (p = 0.038); neither cystatin C (p = 0.096) nor minimal residual renal function (p = 0.756) reached a significant association with cardiovascular disease. Conclusions: In this group of peritoneal dialysis patients, cystatin C did not correlate with the metabolic or inflammatory status, nor cardiovascular disease, after adjustment for residual renal function. |
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Does Cystatin C have a role as metabolic surrogate in peritoneal dialysis beyond its association with residual renal function?Teria a Cistatina C um papel como substituto metabólico na diálise peritoneal além de sua associação com a função renal residual?Cystatin CCardiovascular DiseasesPeritoneal DialysisIntroduction: It has been suggested that cystatin C levels are modified by obesity and inflammation. Furthermore, cystatin C has been associated with cardiovascular events and mortality outcomes. Aim: To study the association of cystatin C with the metabolic profile and cardiovascular disease of peritoneal dialysis patients. Methods: Data collected included clinical, laboratorial, and multifrequency bioimpedance assessment of 52 stable peritoneal dialysis patients. Minimal residual renal function was defined as > 2mL/min/1.73m2. Results: Serum cystatin C was not significantly associated with peritoneal or urinary cystatin C excretion. Negative correlation of cystatin C with normalized protein catabolic rate (rho -0.33, p = 0.02) and a trend towards positive correlation with relative body fat (rho 0.27, p = 0.05) were not independent from residual renal function. Cystatin C was not significantly associated with cardiovascular disease (p = 0.28), nor with glycated hemoglobin (p = 0.19) or c-reactive protein (p = 0.56). In the multivariate model, both age and diabetes were the strongest predictors of cardiovascular disease (odds ratio 1.09, p = 0.029 and odds ratio 29.95, p = 0.016, respectively), while relative body fat was negatively associated with cardiovascular disease (p = 0.038); neither cystatin C (p = 0.096) nor minimal residual renal function (p = 0.756) reached a significant association with cardiovascular disease. Conclusions: In this group of peritoneal dialysis patients, cystatin C did not correlate with the metabolic or inflammatory status, nor cardiovascular disease, after adjustment for residual renal function.Introdução:: Tem sido sugerido que os níveis de cistatina C são modificados pela obesidade e inflamação. Além disso, a cistatina C tem sido associada a eventos cardiovasculares e desfechos de mortalidade. Objetivo:: Estudar a associação da cistatina C com o perfil metabólico e doença cardiovascular de pacientes em diálise peritoneal. Métodos:: Os dados coletados incluíram avaliação clínica, laboratorial e de bioimpedância múltipla de 52 pacientes estáveis em diálise peritoneal. A função renal residual mínima foi definida como > 2mL/min/1,73m2. Resultados:: A cistatina C sérica não esteve significativamente associada à excreção peritoneal ou urinária. A correlação negativa da cistatina C com a taxa catabólica protéica normalizada (rho -0,33, p = 0,02) e uma tendência de correlação positiva com a gordura corporal relativa (rho 0,27, p = 0,05) não foram independentes da função renal residual. A cistatina C não se associou significativamente à doença cardiovascular (p = 0,28), nem com hemoglobina glicada (p = 0,19) ou proteína C reativa (p = 0,56). No modelo multivariado, idade e diabetes foram os mais fortes preditores de doença cardiovascular (razões de probabilidade 1,09, p = 0,029 e 29,95, p = 0,016, respectivamente) enquanto a gordura corporal relativa se associou negativamente à doença cardiovascular (p = 0,038). A cistatina C não se associou significativamente com doença cardiovascular (p = 0,096), tampouco a função residual mínima (p = 0,756). Conclusão:: Neste grupo de pacientes em diálise peritoneal, a cistatina C não se correlacionou com o estado metabólico ou inflamatório, nem com doença cardiovascular, após ajuste para função renal residual.Sociedade Brasileira de NefrologiaRepositório Científico do Centro Hospitalar Universitário de Santo AntónioLeal Moreira, CarlaCunha, LilianaCorreia, SofiaSilva, FilipaCastro, AnaTavares, Joana ManuelCarvalho, Maria JoãoOliveira, José CarlosSantos, Maria OliviaCabrita, AntonioRodrigues, Anabela2022-01-11T15:34:03Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://hdl.handle.net/10400.16/2656engMoreira CL, Cunha L, Correia S, et al. Does Cystatin C have a role as metabolic surrogate in peritoneal dialysis beyond its association with residual renal function?. J Bras Nefrol. 2020;42(1):31-37. doi:10.1590/2175-8239-JBN-2019-00070101-280010.1590/2175-8239-jbn-2019-0007info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-20T11:01:30Zoai:repositorio.chporto.pt:10400.16/2656Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:38:51.339856Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Does Cystatin C have a role as metabolic surrogate in peritoneal dialysis beyond its association with residual renal function? Teria a Cistatina C um papel como substituto metabólico na diálise peritoneal além de sua associação com a função renal residual? |
title |
Does Cystatin C have a role as metabolic surrogate in peritoneal dialysis beyond its association with residual renal function? |
spellingShingle |
Does Cystatin C have a role as metabolic surrogate in peritoneal dialysis beyond its association with residual renal function? Leal Moreira, Carla Cystatin C Cardiovascular Diseases Peritoneal Dialysis |
title_short |
Does Cystatin C have a role as metabolic surrogate in peritoneal dialysis beyond its association with residual renal function? |
title_full |
Does Cystatin C have a role as metabolic surrogate in peritoneal dialysis beyond its association with residual renal function? |
title_fullStr |
Does Cystatin C have a role as metabolic surrogate in peritoneal dialysis beyond its association with residual renal function? |
title_full_unstemmed |
Does Cystatin C have a role as metabolic surrogate in peritoneal dialysis beyond its association with residual renal function? |
title_sort |
Does Cystatin C have a role as metabolic surrogate in peritoneal dialysis beyond its association with residual renal function? |
author |
Leal Moreira, Carla |
author_facet |
Leal Moreira, Carla Cunha, Liliana Correia, Sofia Silva, Filipa Castro, Ana Tavares, Joana Manuel Carvalho, Maria João Oliveira, José Carlos Santos, Maria Olivia Cabrita, Antonio Rodrigues, Anabela |
author_role |
author |
author2 |
Cunha, Liliana Correia, Sofia Silva, Filipa Castro, Ana Tavares, Joana Manuel Carvalho, Maria João Oliveira, José Carlos Santos, Maria Olivia Cabrita, Antonio Rodrigues, Anabela |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Centro Hospitalar Universitário de Santo António |
dc.contributor.author.fl_str_mv |
Leal Moreira, Carla Cunha, Liliana Correia, Sofia Silva, Filipa Castro, Ana Tavares, Joana Manuel Carvalho, Maria João Oliveira, José Carlos Santos, Maria Olivia Cabrita, Antonio Rodrigues, Anabela |
dc.subject.por.fl_str_mv |
Cystatin C Cardiovascular Diseases Peritoneal Dialysis |
topic |
Cystatin C Cardiovascular Diseases Peritoneal Dialysis |
description |
Introduction: It has been suggested that cystatin C levels are modified by obesity and inflammation. Furthermore, cystatin C has been associated with cardiovascular events and mortality outcomes. Aim: To study the association of cystatin C with the metabolic profile and cardiovascular disease of peritoneal dialysis patients. Methods: Data collected included clinical, laboratorial, and multifrequency bioimpedance assessment of 52 stable peritoneal dialysis patients. Minimal residual renal function was defined as > 2mL/min/1.73m2. Results: Serum cystatin C was not significantly associated with peritoneal or urinary cystatin C excretion. Negative correlation of cystatin C with normalized protein catabolic rate (rho -0.33, p = 0.02) and a trend towards positive correlation with relative body fat (rho 0.27, p = 0.05) were not independent from residual renal function. Cystatin C was not significantly associated with cardiovascular disease (p = 0.28), nor with glycated hemoglobin (p = 0.19) or c-reactive protein (p = 0.56). In the multivariate model, both age and diabetes were the strongest predictors of cardiovascular disease (odds ratio 1.09, p = 0.029 and odds ratio 29.95, p = 0.016, respectively), while relative body fat was negatively associated with cardiovascular disease (p = 0.038); neither cystatin C (p = 0.096) nor minimal residual renal function (p = 0.756) reached a significant association with cardiovascular disease. Conclusions: In this group of peritoneal dialysis patients, cystatin C did not correlate with the metabolic or inflammatory status, nor cardiovascular disease, after adjustment for residual renal function. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020 2020-01-01T00:00:00Z 2022-01-11T15:34:03Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.16/2656 |
url |
http://hdl.handle.net/10400.16/2656 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Moreira CL, Cunha L, Correia S, et al. Does Cystatin C have a role as metabolic surrogate in peritoneal dialysis beyond its association with residual renal function?. J Bras Nefrol. 2020;42(1):31-37. doi:10.1590/2175-8239-JBN-2019-0007 0101-2800 10.1590/2175-8239-jbn-2019-0007 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Nefrologia |
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Sociedade Brasileira de Nefrologia |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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