Late sequelae of congenital cytomegalovirus infection - The urgency of a neonatal approach

Detalhes bibliográficos
Autor(a) principal: Botelho,Teresa
Data de Publicação: 2023
Outros Autores: Gonçalves,Raquel, Tiago,Joaquim, Silva,Ana Rodrigues
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-07542023000200072
Resumo: Abstract Introduction: Congenital cytomegalovirus (CMV) infection is the main cause of sensorineural deafness in children. In Portugal, routine screening of the infection during pregnancy is not performed. It is acknowledged that late sequelae may occur in children with congenital infections, even when they are asymptomatic at birth. The aim of this study was to investigate early and late sequelae in children of mothers with positive CMV immunoglobulin (Ig) M and IgG during pregnancy. Materials and Methods: Patients: Children born to mothers with positive CMV IgM and IgG during pregnancy at a Portuguese tertiary hospital between August 2006 and August 2020. Demographic, clinical, and laboratory variables and early and late sequelae were retrospectively assessed. Late sequelae included delayed psychomotor development, sensorineural deafness, and vision changes. Results: In the last 14 years, 31 newborns were born to mothers with positive IgM and IgG during pregnancy in the considered hospital (0.08% of the total number of births). CMV infection was confirmed in six of these children (19.4%), of whom one was symptomatic at birth, with multiorgan involvement, and died at the age of four months. Late sequelae were observed in one patient, specifically learning disabilities and attention-deficit/hyperactivity disorder. No cases of ophthalmological or otorhinolaryngological alterations were identified. Discussion: Although congenital CMV infection is a potentially fatal condition, only one death was reported in the present study sample. Late sequelae were also only observed in one case, which was asymptomatic at birth. Conclusion: These results suggest that the indications for CMV screening during the neonatal period should be reassessed. This is particularly important in asymptomatic newborns, as a way to implement early treatment and prevent late sequelae.
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spelling Late sequelae of congenital cytomegalovirus infection - The urgency of a neonatal approachcomplicationcytomegalovirus infectiondiagnosisneurodevelopmental disorderAbstract Introduction: Congenital cytomegalovirus (CMV) infection is the main cause of sensorineural deafness in children. In Portugal, routine screening of the infection during pregnancy is not performed. It is acknowledged that late sequelae may occur in children with congenital infections, even when they are asymptomatic at birth. The aim of this study was to investigate early and late sequelae in children of mothers with positive CMV immunoglobulin (Ig) M and IgG during pregnancy. Materials and Methods: Patients: Children born to mothers with positive CMV IgM and IgG during pregnancy at a Portuguese tertiary hospital between August 2006 and August 2020. Demographic, clinical, and laboratory variables and early and late sequelae were retrospectively assessed. Late sequelae included delayed psychomotor development, sensorineural deafness, and vision changes. Results: In the last 14 years, 31 newborns were born to mothers with positive IgM and IgG during pregnancy in the considered hospital (0.08% of the total number of births). CMV infection was confirmed in six of these children (19.4%), of whom one was symptomatic at birth, with multiorgan involvement, and died at the age of four months. Late sequelae were observed in one patient, specifically learning disabilities and attention-deficit/hyperactivity disorder. No cases of ophthalmological or otorhinolaryngological alterations were identified. Discussion: Although congenital CMV infection is a potentially fatal condition, only one death was reported in the present study sample. Late sequelae were also only observed in one case, which was asymptomatic at birth. Conclusion: These results suggest that the indications for CMV screening during the neonatal period should be reassessed. This is particularly important in asymptomatic newborns, as a way to implement early treatment and prevent late sequelae.Centro Hospitalar do Porto2023-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articletext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-07542023000200072Nascer e Crescer v.32 n.2 2023reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-07542023000200072Botelho,TeresaGonçalves,RaquelTiago,JoaquimSilva,Ana Rodriguesinfo:eu-repo/semantics/openAccess2024-02-06T17:06:37Zoai:scielo:S0872-07542023000200072Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:19:54.097332Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Late sequelae of congenital cytomegalovirus infection - The urgency of a neonatal approach
title Late sequelae of congenital cytomegalovirus infection - The urgency of a neonatal approach
spellingShingle Late sequelae of congenital cytomegalovirus infection - The urgency of a neonatal approach
Botelho,Teresa
complication
cytomegalovirus infection
diagnosis
neurodevelopmental disorder
title_short Late sequelae of congenital cytomegalovirus infection - The urgency of a neonatal approach
title_full Late sequelae of congenital cytomegalovirus infection - The urgency of a neonatal approach
title_fullStr Late sequelae of congenital cytomegalovirus infection - The urgency of a neonatal approach
title_full_unstemmed Late sequelae of congenital cytomegalovirus infection - The urgency of a neonatal approach
title_sort Late sequelae of congenital cytomegalovirus infection - The urgency of a neonatal approach
author Botelho,Teresa
author_facet Botelho,Teresa
Gonçalves,Raquel
Tiago,Joaquim
Silva,Ana Rodrigues
author_role author
author2 Gonçalves,Raquel
Tiago,Joaquim
Silva,Ana Rodrigues
author2_role author
author
author
dc.contributor.author.fl_str_mv Botelho,Teresa
Gonçalves,Raquel
Tiago,Joaquim
Silva,Ana Rodrigues
dc.subject.por.fl_str_mv complication
cytomegalovirus infection
diagnosis
neurodevelopmental disorder
topic complication
cytomegalovirus infection
diagnosis
neurodevelopmental disorder
description Abstract Introduction: Congenital cytomegalovirus (CMV) infection is the main cause of sensorineural deafness in children. In Portugal, routine screening of the infection during pregnancy is not performed. It is acknowledged that late sequelae may occur in children with congenital infections, even when they are asymptomatic at birth. The aim of this study was to investigate early and late sequelae in children of mothers with positive CMV immunoglobulin (Ig) M and IgG during pregnancy. Materials and Methods: Patients: Children born to mothers with positive CMV IgM and IgG during pregnancy at a Portuguese tertiary hospital between August 2006 and August 2020. Demographic, clinical, and laboratory variables and early and late sequelae were retrospectively assessed. Late sequelae included delayed psychomotor development, sensorineural deafness, and vision changes. Results: In the last 14 years, 31 newborns were born to mothers with positive IgM and IgG during pregnancy in the considered hospital (0.08% of the total number of births). CMV infection was confirmed in six of these children (19.4%), of whom one was symptomatic at birth, with multiorgan involvement, and died at the age of four months. Late sequelae were observed in one patient, specifically learning disabilities and attention-deficit/hyperactivity disorder. No cases of ophthalmological or otorhinolaryngological alterations were identified. Discussion: Although congenital CMV infection is a potentially fatal condition, only one death was reported in the present study sample. Late sequelae were also only observed in one case, which was asymptomatic at birth. Conclusion: These results suggest that the indications for CMV screening during the neonatal period should be reassessed. This is particularly important in asymptomatic newborns, as a way to implement early treatment and prevent late sequelae.
publishDate 2023
dc.date.none.fl_str_mv 2023-06-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-07542023000200072
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Centro Hospitalar do Porto
publisher.none.fl_str_mv Centro Hospitalar do Porto
dc.source.none.fl_str_mv Nascer e Crescer v.32 n.2 2023
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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