Treatment of Inflammatory Bowel Disease: Is your Patient at Risk of Non-Adherence?
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5090 |
Resumo: | Introduction: Adherence to therapy is a key factor when analyzing the efficacy of a treatment in clinical practice. The aim of our study was to assess the frequency of non-adherence to treatment among patients with inflammatory bowel disease and evaluate which factors could be related.Material and Methods: One hundred thirty eight consecutive inflammatory bowel disease outpatients (55.8% with Crohn’s disease and 44.2% with Ulcerative Colitis) filled in an anonymous questionnaire, which included information about demography, duration of the disease, specific therapy for inflammatory bowel disease, and data possibly related to extent of non-adherence to treatment. Statistics were performed with SPSS v.18.0. Categorical variables were compared with Fisher’s exact test. A p value < 0.05 was considered statistically significant. Significant variables in univariate analysis were included in the logistic regression analysis.Results: Overall non-adherence was reported by 29.7% of patients. 70.7% of them reported unintentional non-adherence and 51.2% forgot at least one dose per week. Non-adherence was statistically associated with: short disease duration (p < 0.001); young age (p = 0.001); topical aminosalicylates (p = 0.005); the perception that medical therapy isn’t effective enough (p = 0.007) and high educational level (p = 0.011). In a logistic regression analysis, topical aminosalicylates use (p = 0.004), short disease duration (p = 0.006) and young age (p = 0.027) were identified as significant predictors of non-adherence.Discussion: Young patients, patients with short disease duration and under topical aminosalicyates presented a higher risk for nonadherence to treatment.Conclusions: Gastroenterologist’s attention should be focused on the identification of risk factors potentially involved in non-adherence to therapy and in the promotion of measures to improve it.Keywords: Inflammatory Bowel Disease; Crohn Disease; Colitis, Ulcerative; Patient Compliance; Risk Factors; Treatment Refusal. |
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Treatment of Inflammatory Bowel Disease: Is your Patient at Risk of Non-Adherence?Tratamento da Doença Inflamatória Intestinal: Estará o seu Doente em Risco de Não Adesão?Introduction: Adherence to therapy is a key factor when analyzing the efficacy of a treatment in clinical practice. The aim of our study was to assess the frequency of non-adherence to treatment among patients with inflammatory bowel disease and evaluate which factors could be related.Material and Methods: One hundred thirty eight consecutive inflammatory bowel disease outpatients (55.8% with Crohn’s disease and 44.2% with Ulcerative Colitis) filled in an anonymous questionnaire, which included information about demography, duration of the disease, specific therapy for inflammatory bowel disease, and data possibly related to extent of non-adherence to treatment. Statistics were performed with SPSS v.18.0. Categorical variables were compared with Fisher’s exact test. A p value < 0.05 was considered statistically significant. Significant variables in univariate analysis were included in the logistic regression analysis.Results: Overall non-adherence was reported by 29.7% of patients. 70.7% of them reported unintentional non-adherence and 51.2% forgot at least one dose per week. Non-adherence was statistically associated with: short disease duration (p < 0.001); young age (p = 0.001); topical aminosalicylates (p = 0.005); the perception that medical therapy isn’t effective enough (p = 0.007) and high educational level (p = 0.011). In a logistic regression analysis, topical aminosalicylates use (p = 0.004), short disease duration (p = 0.006) and young age (p = 0.027) were identified as significant predictors of non-adherence.Discussion: Young patients, patients with short disease duration and under topical aminosalicyates presented a higher risk for nonadherence to treatment.Conclusions: Gastroenterologist’s attention should be focused on the identification of risk factors potentially involved in non-adherence to therapy and in the promotion of measures to improve it.Keywords: Inflammatory Bowel Disease; Crohn Disease; Colitis, Ulcerative; Patient Compliance; Risk Factors; Treatment Refusal.Introdução: A adesão à terapêutica é um aspecto chave para a eficácia da terapêutica. O objectivo deste estudo foi avaliar a frequência e factores de risco associados à não adesão à terapêutica na doença inflamatória intestinal.Material e Métodos: Cento e trinta e oito doentes com doença inflamatória intestinal (55,8% com Doença de Crohn e 44,2% com Colite Ulcerosa) preencheram um questionário sobre dados referentes à sua doença e comportamentos de não adesão ao tratamento. A análise estatística foi realizada com SPSS 18, a associação entre variáveis categóricas foi determinada através do teste exato de Fisher. Variáveis estatisticamente significativas na análise univariada foram incluídas no modelo de regressão logística.Resultados: A não-adesão à terapêutica foi registada em 29,7% dos doentes. Em 70,7% dos casos foram referidos comportamentos não intencionais e 51,2% esqueceram pelo menos uma dose por semana. A não-adesão à terapêutica apresentou uma associação significativa com o diagnóstico recente da doença (p < 0,001), idade jovem (p = 0,001), aminossalicilatos tópicos (p = 0,005), percepção individual de baixa eficácia da terapêutica (p = 0,007) e uma escolaridade elevada (p = 0,011). No modelo de regressão logística os aminossalicilatos tópicos (p = 0,004), o diagnóstico recente da doença (p = 0,006) e a idade jovem (p = 0,027), foram identificados como preditores de não adesão à terapêutica.Discussão: Doentes jovens, com diagnóstico recente e sob terapêutica com aminossalicilatos tópicos apresentaram um maior risco para comportamentos de não adesão.Conclusões: A atenção dos gastrenterologistas deve focar-se na identificação dos fatores de risco envolvidos na não adesão e na promoção de medidas que contribuam para a diminuição da mesma.Palavras-chave: Doença Inflamatória Intestinal; Doença de Crohn; Colite Ulcerosa; Cooperação do Doente; Factores de Risco; Recusa do Doente ao Tratamento.Ordem dos Médicos2014-09-25info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5090oai:ojs.www.actamedicaportuguesa.com:article/5090Acta Médica Portuguesa; Vol. 27 No. 5 (2014): September-October; 576-580Acta Médica Portuguesa; Vol. 27 N.º 5 (2014): Setembro-Outubro; 576-5801646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5090https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5090/4061Magalhães, JoanaDias de Castro, FranciscaBoal Carvalho, PedroLeite, SílviaMoreira, Maria JoãoCotter, Joséinfo:eu-repo/semantics/openAccess2022-12-20T11:04:12Zoai:ojs.www.actamedicaportuguesa.com:article/5090Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:19:01.768622Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Treatment of Inflammatory Bowel Disease: Is your Patient at Risk of Non-Adherence? Tratamento da Doença Inflamatória Intestinal: Estará o seu Doente em Risco de Não Adesão? |
title |
Treatment of Inflammatory Bowel Disease: Is your Patient at Risk of Non-Adherence? |
spellingShingle |
Treatment of Inflammatory Bowel Disease: Is your Patient at Risk of Non-Adherence? Magalhães, Joana |
title_short |
Treatment of Inflammatory Bowel Disease: Is your Patient at Risk of Non-Adherence? |
title_full |
Treatment of Inflammatory Bowel Disease: Is your Patient at Risk of Non-Adherence? |
title_fullStr |
Treatment of Inflammatory Bowel Disease: Is your Patient at Risk of Non-Adherence? |
title_full_unstemmed |
Treatment of Inflammatory Bowel Disease: Is your Patient at Risk of Non-Adherence? |
title_sort |
Treatment of Inflammatory Bowel Disease: Is your Patient at Risk of Non-Adherence? |
author |
Magalhães, Joana |
author_facet |
Magalhães, Joana Dias de Castro, Francisca Boal Carvalho, Pedro Leite, Sílvia Moreira, Maria João Cotter, José |
author_role |
author |
author2 |
Dias de Castro, Francisca Boal Carvalho, Pedro Leite, Sílvia Moreira, Maria João Cotter, José |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Magalhães, Joana Dias de Castro, Francisca Boal Carvalho, Pedro Leite, Sílvia Moreira, Maria João Cotter, José |
description |
Introduction: Adherence to therapy is a key factor when analyzing the efficacy of a treatment in clinical practice. The aim of our study was to assess the frequency of non-adherence to treatment among patients with inflammatory bowel disease and evaluate which factors could be related.Material and Methods: One hundred thirty eight consecutive inflammatory bowel disease outpatients (55.8% with Crohn’s disease and 44.2% with Ulcerative Colitis) filled in an anonymous questionnaire, which included information about demography, duration of the disease, specific therapy for inflammatory bowel disease, and data possibly related to extent of non-adherence to treatment. Statistics were performed with SPSS v.18.0. Categorical variables were compared with Fisher’s exact test. A p value < 0.05 was considered statistically significant. Significant variables in univariate analysis were included in the logistic regression analysis.Results: Overall non-adherence was reported by 29.7% of patients. 70.7% of them reported unintentional non-adherence and 51.2% forgot at least one dose per week. Non-adherence was statistically associated with: short disease duration (p < 0.001); young age (p = 0.001); topical aminosalicylates (p = 0.005); the perception that medical therapy isn’t effective enough (p = 0.007) and high educational level (p = 0.011). In a logistic regression analysis, topical aminosalicylates use (p = 0.004), short disease duration (p = 0.006) and young age (p = 0.027) were identified as significant predictors of non-adherence.Discussion: Young patients, patients with short disease duration and under topical aminosalicyates presented a higher risk for nonadherence to treatment.Conclusions: Gastroenterologist’s attention should be focused on the identification of risk factors potentially involved in non-adherence to therapy and in the promotion of measures to improve it.Keywords: Inflammatory Bowel Disease; Crohn Disease; Colitis, Ulcerative; Patient Compliance; Risk Factors; Treatment Refusal. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-09-25 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
format |
article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5090 oai:ojs.www.actamedicaportuguesa.com:article/5090 |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5090 |
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oai:ojs.www.actamedicaportuguesa.com:article/5090 |
dc.language.iso.fl_str_mv |
eng |
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eng |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5090 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5090/4061 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Ordem dos Médicos |
publisher.none.fl_str_mv |
Ordem dos Médicos |
dc.source.none.fl_str_mv |
Acta Médica Portuguesa; Vol. 27 No. 5 (2014): September-October; 576-580 Acta Médica Portuguesa; Vol. 27 N.º 5 (2014): Setembro-Outubro; 576-580 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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