A distinct neuromelanin magnetic resonance imaging pattern in parkinsonian multiple system atrophy

Detalhes bibliográficos
Autor(a) principal: Simões, Rita Moiron
Data de Publicação: 2020
Outros Autores: Castro Caldas, Ana, Grilo, Joana, Correia, Daisy, Guerreiro, Carla, Pita Lobo, Patrícia, Valadas, Anabela, Fabbri, Marguerita, Correia Guedes, Leonor, Coelho, Miguel, Rosa, Mário Miguel, Ferreira, Joaquim J, Reimão, Sofia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/47252
Resumo: © The Author(s) 2020. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
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spelling A distinct neuromelanin magnetic resonance imaging pattern in parkinsonian multiple system atrophyMRIMultiple system atrophyNeuromelaninNigrosome 1Susceptibility-weighted imaging© The Author(s) 2020. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.Background: Parkinsonian variant of multiple system atrophy is a neurodegenerative disorder frequently misdiagnosed as Parkinson's disease. No early imaging biomarkers currently differentiate these disorders. Methods: Simple visual imaging analysis of the substantia nigra and locus coeruleus in neuromelanin-sensitive magnetic resonance imaging and nigrosome 1 in susceptibility-weighted sequences was performed in thirty patients with parkinsonian variant of multiple system atrophy fulfilling possible/probable second consensus diagnostic criteria. The neuromelanin visual pattern was compared to patients with Parkinson's disease with the same disease duration (n = 10) and healthy controls (n = 10). Substantia nigra semi-automated neuromelanin area/signal intensity was compared to the visual data. Results: Groups were similar in age, sex, disease duration, and levodopa equivalent dose. Hoehn & Yahr stage was higher in parkinsonian multiple system atrophy patients, 69% of whom had normal neuromelanin size/signal, significantly different from Parkinson's disease patients, and similar to controls. Nigrosome 1 signal was lost in 74% of parkinsonian multiple system atrophy patients. Semi-automated neuromelanin substantia nigra signal, but not area, measurements were able to differentiate groups. Conclusions: In patients with parkinsonism, simple visual magnetic resonance imaging analysis showing normal neuromelanin substantia nigra and locus coeruleus, combined with nigrosome 1 loss, allowed the distinction of the parkinsonian variant of multiple system atrophy from Parkinson's disease and healthy controls. This easy and widely available method was superior to semi-automated measurements in identifying specific imaging changes in substantia nigra and locus coeruleus.Springer NatureRepositório da Universidade de LisboaSimões, Rita MoironCastro Caldas, AnaGrilo, JoanaCorreia, DaisyGuerreiro, CarlaPita Lobo, PatríciaValadas, AnabelaFabbri, MargueritaCorreia Guedes, LeonorCoelho, MiguelRosa, Mário MiguelFerreira, Joaquim JReimão, Sofia2021-04-06T12:35:21Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/47252engBMC Neurol. 2020 Nov 27;20(1):43210.1186/s12883-020-02007-51471-2377info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:50:02Zoai:repositorio.ul.pt:10451/47252Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:59:19.744865Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv A distinct neuromelanin magnetic resonance imaging pattern in parkinsonian multiple system atrophy
title A distinct neuromelanin magnetic resonance imaging pattern in parkinsonian multiple system atrophy
spellingShingle A distinct neuromelanin magnetic resonance imaging pattern in parkinsonian multiple system atrophy
Simões, Rita Moiron
MRI
Multiple system atrophy
Neuromelanin
Nigrosome 1
Susceptibility-weighted imaging
title_short A distinct neuromelanin magnetic resonance imaging pattern in parkinsonian multiple system atrophy
title_full A distinct neuromelanin magnetic resonance imaging pattern in parkinsonian multiple system atrophy
title_fullStr A distinct neuromelanin magnetic resonance imaging pattern in parkinsonian multiple system atrophy
title_full_unstemmed A distinct neuromelanin magnetic resonance imaging pattern in parkinsonian multiple system atrophy
title_sort A distinct neuromelanin magnetic resonance imaging pattern in parkinsonian multiple system atrophy
author Simões, Rita Moiron
author_facet Simões, Rita Moiron
Castro Caldas, Ana
Grilo, Joana
Correia, Daisy
Guerreiro, Carla
Pita Lobo, Patrícia
Valadas, Anabela
Fabbri, Marguerita
Correia Guedes, Leonor
Coelho, Miguel
Rosa, Mário Miguel
Ferreira, Joaquim J
Reimão, Sofia
author_role author
author2 Castro Caldas, Ana
Grilo, Joana
Correia, Daisy
Guerreiro, Carla
Pita Lobo, Patrícia
Valadas, Anabela
Fabbri, Marguerita
Correia Guedes, Leonor
Coelho, Miguel
Rosa, Mário Miguel
Ferreira, Joaquim J
Reimão, Sofia
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Simões, Rita Moiron
Castro Caldas, Ana
Grilo, Joana
Correia, Daisy
Guerreiro, Carla
Pita Lobo, Patrícia
Valadas, Anabela
Fabbri, Marguerita
Correia Guedes, Leonor
Coelho, Miguel
Rosa, Mário Miguel
Ferreira, Joaquim J
Reimão, Sofia
dc.subject.por.fl_str_mv MRI
Multiple system atrophy
Neuromelanin
Nigrosome 1
Susceptibility-weighted imaging
topic MRI
Multiple system atrophy
Neuromelanin
Nigrosome 1
Susceptibility-weighted imaging
description © The Author(s) 2020. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
2021-04-06T12:35:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/47252
url http://hdl.handle.net/10451/47252
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv BMC Neurol. 2020 Nov 27;20(1):432
10.1186/s12883-020-02007-5
1471-2377
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dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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