Team approach to ERCP-directed single-brush cytology for the diagnosis of malignancy

Detalhes bibliográficos
Autor(a) principal: Urbano, M.
Data de Publicação: 2008
Outros Autores: Rosa, A., Gomes, D., Camacho, E., Calhau, C. A., Leitão, M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/12612
https://doi.org/10.4321/S1130-01082008000800003
Resumo: OBJECTIVE: To evaluate the clinical usefulness of single-brush cytology performed at ERCP as initial method for detecting pancreatobiliary malignancy, ensuring a very close relationship between endoscopists, cytotechnicians, and cytopathologists. STUDY DESIGN: All 125 cytodiagnoses considered in this study correspond to the first brushing for each patient, collected by one of the three members of a fixed team of endoscopists in the presence of the same cytotechnician. Smears were fixed immediately with Merckofix spray, stained with Papanicolau, and analyzed by the same cytopathologist in a laboratory exclusively devoted to gastrointestinal cytopathology located at the endoscopy unit. RESULTS: Of 125 cytological diagnoses 94 were considered benign, 4 suspicious, and 27 malignant. These findings were compared to the final diagnosis of 45 malignant and 80 benign lesions obtained either by surgical pathology or after at least one year of clinical follow-up. The comparison yielded 30 true positives, 78 true negatives, 1 false positive and 16 false negative results, which corresponds to a sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 65.2, 98.7, 96.8, 83, and 86.4%, respectively. CONCLUSION: Results seem to confirm the usefulness of an effective team approach to ERCP-directed brush cytology for the diagnosis of pancreatobiliary malignancy. However, sensitivity continues to be rather low
id RCAP_ab7b5d7a226d74dc6bf6a21d90effab0
oai_identifier_str oai:estudogeral.uc.pt:10316/12612
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Team approach to ERCP-directed single-brush cytology for the diagnosis of malignancyPancreatic malignancyBiliary malignancyEndoscopic retrograde cholangiopancreatography (ERCP)Brush cytologyDiagnosisOBJECTIVE: To evaluate the clinical usefulness of single-brush cytology performed at ERCP as initial method for detecting pancreatobiliary malignancy, ensuring a very close relationship between endoscopists, cytotechnicians, and cytopathologists. STUDY DESIGN: All 125 cytodiagnoses considered in this study correspond to the first brushing for each patient, collected by one of the three members of a fixed team of endoscopists in the presence of the same cytotechnician. Smears were fixed immediately with Merckofix spray, stained with Papanicolau, and analyzed by the same cytopathologist in a laboratory exclusively devoted to gastrointestinal cytopathology located at the endoscopy unit. RESULTS: Of 125 cytological diagnoses 94 were considered benign, 4 suspicious, and 27 malignant. These findings were compared to the final diagnosis of 45 malignant and 80 benign lesions obtained either by surgical pathology or after at least one year of clinical follow-up. The comparison yielded 30 true positives, 78 true negatives, 1 false positive and 16 false negative results, which corresponds to a sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 65.2, 98.7, 96.8, 83, and 86.4%, respectively. CONCLUSION: Results seem to confirm the usefulness of an effective team approach to ERCP-directed brush cytology for the diagnosis of pancreatobiliary malignancy. However, sensitivity continues to be rather lowObjetivo: evaluar la utilidad clínica de la citología con cepillo único durante la CPRE como método inicial de detección de los cánceres pancreaticobiliares, garantizando una relación muy cer- cana entre endoscopistas, citotécnicos y citopatólogos. Diseño del estudio: los 125 citodiagnósticos considerados por este estudio corresponden al primer cepillado de cada pacien- te, realizado por uno de los tres miembros de un equipo fijo de endoscopistas en presencia del mismo citotécnico. Los frotis se fi- jaron inmediatamente con Merckofix® en aerosol, se tiñeron con Papanicolau y se analizaron por un mismo citopatólogo en un la- boratorio exclusivamente dedicado a la citopatología digestiva y situado en la unidad de endoscopia. Resultados: de los 125 diagnósticos citológicos, 94 se conside- raron benignos, 4 sospechosos y 27 malignos. Estos hallazgos se compararon con el diagnóstico final de 45 lesiones malignas y 80 le- siones benignas, obtenido mediante patología quirúrgica o con un año al menos de seguimiento clínico. La comparación arrojó 30 posi- tivos verdaderos, 78 negativos verdaderos, 1 positivo falso y 16 nega- tivos falsos, lo que corresponde a una sensibilidad, una especificidad, un valor pronóstico positivo, un valor pronóstico negativo y una pre- cisión del 65,2, el 98,7, el 96,8, el 83 y el 86,4%, respectivamente. Conclusión: los resultados parecen confirmar la utilidad de un abordaje en equipo eficaz de la citología con cepillo guiada por CPRE para el diagnóstico del cáncer pancreaticobiliar. Sin embar- go, la sensibilidad sigue siendo más bien bajaGrupo Aran2008info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/12612http://hdl.handle.net/10316/12612https://doi.org/10.4321/S1130-01082008000800003engRevista Española de Enfermedades Digestivas. 100:8 (2008) 462-4651130-0108Urbano, M.Rosa, A.Gomes, D.Camacho, E.Calhau, C. A.Leitão, M.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-05-25T03:55:44Zoai:estudogeral.uc.pt:10316/12612Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:43:37.294294Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Team approach to ERCP-directed single-brush cytology for the diagnosis of malignancy
title Team approach to ERCP-directed single-brush cytology for the diagnosis of malignancy
spellingShingle Team approach to ERCP-directed single-brush cytology for the diagnosis of malignancy
Urbano, M.
Pancreatic malignancy
Biliary malignancy
Endoscopic retrograde cholangiopancreatography (ERCP)
Brush cytology
Diagnosis
title_short Team approach to ERCP-directed single-brush cytology for the diagnosis of malignancy
title_full Team approach to ERCP-directed single-brush cytology for the diagnosis of malignancy
title_fullStr Team approach to ERCP-directed single-brush cytology for the diagnosis of malignancy
title_full_unstemmed Team approach to ERCP-directed single-brush cytology for the diagnosis of malignancy
title_sort Team approach to ERCP-directed single-brush cytology for the diagnosis of malignancy
author Urbano, M.
author_facet Urbano, M.
Rosa, A.
Gomes, D.
Camacho, E.
Calhau, C. A.
Leitão, M.
author_role author
author2 Rosa, A.
Gomes, D.
Camacho, E.
Calhau, C. A.
Leitão, M.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Urbano, M.
Rosa, A.
Gomes, D.
Camacho, E.
Calhau, C. A.
Leitão, M.
dc.subject.por.fl_str_mv Pancreatic malignancy
Biliary malignancy
Endoscopic retrograde cholangiopancreatography (ERCP)
Brush cytology
Diagnosis
topic Pancreatic malignancy
Biliary malignancy
Endoscopic retrograde cholangiopancreatography (ERCP)
Brush cytology
Diagnosis
description OBJECTIVE: To evaluate the clinical usefulness of single-brush cytology performed at ERCP as initial method for detecting pancreatobiliary malignancy, ensuring a very close relationship between endoscopists, cytotechnicians, and cytopathologists. STUDY DESIGN: All 125 cytodiagnoses considered in this study correspond to the first brushing for each patient, collected by one of the three members of a fixed team of endoscopists in the presence of the same cytotechnician. Smears were fixed immediately with Merckofix spray, stained with Papanicolau, and analyzed by the same cytopathologist in a laboratory exclusively devoted to gastrointestinal cytopathology located at the endoscopy unit. RESULTS: Of 125 cytological diagnoses 94 were considered benign, 4 suspicious, and 27 malignant. These findings were compared to the final diagnosis of 45 malignant and 80 benign lesions obtained either by surgical pathology or after at least one year of clinical follow-up. The comparison yielded 30 true positives, 78 true negatives, 1 false positive and 16 false negative results, which corresponds to a sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 65.2, 98.7, 96.8, 83, and 86.4%, respectively. CONCLUSION: Results seem to confirm the usefulness of an effective team approach to ERCP-directed brush cytology for the diagnosis of pancreatobiliary malignancy. However, sensitivity continues to be rather low
publishDate 2008
dc.date.none.fl_str_mv 2008
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/12612
http://hdl.handle.net/10316/12612
https://doi.org/10.4321/S1130-01082008000800003
url http://hdl.handle.net/10316/12612
https://doi.org/10.4321/S1130-01082008000800003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Revista Española de Enfermedades Digestivas. 100:8 (2008) 462-465
1130-0108
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Grupo Aran
publisher.none.fl_str_mv Grupo Aran
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799133707922046976