Proposal for an ecofriendly and economic strategy for efficient radioiodination of coumarin derivatives

Detalhes bibliográficos
Autor(a) principal: Khatir-Hamdi, Nejla
Data de Publicação: 2019
Outros Autores: Makhloufi-Chebli, Malika, Silva, Artur M. S., Brahimi, Méziane, Grib, Hocine
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10773/37705
Resumo: Combination of the calculation of reactivity descriptors and the cold iodine test for some coumarin derivatives was used in order to optimize the radioiodination reaction. The strongly nucleophilic predicted coumarins were subjected to the action of cold iodine. With two coumarins substituted at 3 by the 2-hydroxybenzoyl group, iodination did not occur but a product of intramolecular heterocyclization was obtained. This strategy is useful for economic and environmentally friendly radioiodination.
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spelling Proposal for an ecofriendly and economic strategy for efficient radioiodination of coumarin derivativesCoumarinElectrophilic substitutionTheoretical calculationCold-iodinationRadioiodinationEcofriendly strategyCombination of the calculation of reactivity descriptors and the cold iodine test for some coumarin derivatives was used in order to optimize the radioiodination reaction. The strongly nucleophilic predicted coumarins were subjected to the action of cold iodine. With two coumarins substituted at 3 by the 2-hydroxybenzoyl group, iodination did not occur but a product of intramolecular heterocyclization was obtained. This strategy is useful for economic and environmentally friendly radioiodination.Elsevier2023-05-15T08:29:26Z2019-09-01T00:00:00Z2019-09info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://hdl.handle.net/10773/37705eng0969-804310.1016/j.apradiso.2019.06.024Khatir-Hamdi, NejlaMakhloufi-Chebli, MalikaSilva, Artur M. S.Brahimi, MézianeGrib, Hocineinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T12:13:39Zoai:ria.ua.pt:10773/37705Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:08:18.614765Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Proposal for an ecofriendly and economic strategy for efficient radioiodination of coumarin derivatives
title Proposal for an ecofriendly and economic strategy for efficient radioiodination of coumarin derivatives
spellingShingle Proposal for an ecofriendly and economic strategy for efficient radioiodination of coumarin derivatives
Khatir-Hamdi, Nejla
Coumarin
Electrophilic substitution
Theoretical calculation
Cold-iodination
Radioiodination
Ecofriendly strategy
title_short Proposal for an ecofriendly and economic strategy for efficient radioiodination of coumarin derivatives
title_full Proposal for an ecofriendly and economic strategy for efficient radioiodination of coumarin derivatives
title_fullStr Proposal for an ecofriendly and economic strategy for efficient radioiodination of coumarin derivatives
title_full_unstemmed Proposal for an ecofriendly and economic strategy for efficient radioiodination of coumarin derivatives
title_sort Proposal for an ecofriendly and economic strategy for efficient radioiodination of coumarin derivatives
author Khatir-Hamdi, Nejla
author_facet Khatir-Hamdi, Nejla
Makhloufi-Chebli, Malika
Silva, Artur M. S.
Brahimi, Méziane
Grib, Hocine
author_role author
author2 Makhloufi-Chebli, Malika
Silva, Artur M. S.
Brahimi, Méziane
Grib, Hocine
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Khatir-Hamdi, Nejla
Makhloufi-Chebli, Malika
Silva, Artur M. S.
Brahimi, Méziane
Grib, Hocine
dc.subject.por.fl_str_mv Coumarin
Electrophilic substitution
Theoretical calculation
Cold-iodination
Radioiodination
Ecofriendly strategy
topic Coumarin
Electrophilic substitution
Theoretical calculation
Cold-iodination
Radioiodination
Ecofriendly strategy
description Combination of the calculation of reactivity descriptors and the cold iodine test for some coumarin derivatives was used in order to optimize the radioiodination reaction. The strongly nucleophilic predicted coumarins were subjected to the action of cold iodine. With two coumarins substituted at 3 by the 2-hydroxybenzoyl group, iodination did not occur but a product of intramolecular heterocyclization was obtained. This strategy is useful for economic and environmentally friendly radioiodination.
publishDate 2019
dc.date.none.fl_str_mv 2019-09-01T00:00:00Z
2019-09
2023-05-15T08:29:26Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10773/37705
url http://hdl.handle.net/10773/37705
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0969-8043
10.1016/j.apradiso.2019.06.024
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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