Striatal dopamine D2-like receptors availability in obesity and its modulation by bariatric surgery

Detalhes bibliográficos
Autor(a) principal: Ribeiro, Gabriela
Data de Publicação: 2023
Outros Autores: Maia, Ana, Cotovio, Gonçalo, Oliveira, Francisco P.M., Costa, Durval C., Oliveira-Maia, Albino J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/151587
Resumo: OK
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spelling Striatal dopamine D2-like receptors availability in obesity and its modulation by bariatric surgerya systematic review and meta-analysisGeneralSDG 3 - Good Health and Well-beingOKThere is significant evidence linking a 'reward deficiency syndrome' (RDS), comprising decreased availability of striatal dopamine D2-like receptors (DD2lR) and addiction-like behaviors underlying substance use disorders and obesity. Regarding obesity, a systematic review of the literature with a meta-analysis of such data is lacking. Following a systematic review of the literature, we performed random-effects meta-analyses to determine group differences in case-control studies comparing DD2lR between individuals with obesity and non-obese controls and prospective studies of pre- to post-bariatric surgery DD2lR changes. Cohen's d was used to measure effect size. Additionally, we explored factors potentially associated with group differences in DD2lR availability, such as obesity severity, using univariate meta-regression. In a meta-analysis including positron emission tomography (PET) and single-photon emission computed tomography (SPECT) studies, striatal DD2lR availability did not significantly differ between obesity and controls. However, in studies comprising patients with class III obesity or higher, group differences were significant, favoring lower DD2lR availability in the obesity group. This effect of obesity severity was corroborated by meta-regressions showing inverse associations between the body mass index (BMI) of the obesity group and DD2lR availability. Post-bariatric changes in DD2lR availability were not found, although a limited number of studies were included in this meta-analysis. These results support lower DD2lR in higher classes of obesity which is a more targeted population to explore unanswered questions regarding the RDS.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNRibeiro, GabrielaMaia, AnaCotovio, GonçaloOliveira, Francisco P.M.Costa, Durval C.Oliveira-Maia, Albino J.2023-04-04T22:18:45Z2023-03-272023-03-27T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1application/pdfhttp://hdl.handle.net/10362/151587eng2045-2322PURE: 57557045https://doi.org/10.1038/s41598-023-31250-2info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:34:02Zoai:run.unl.pt:10362/151587Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:54:38.940741Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Striatal dopamine D2-like receptors availability in obesity and its modulation by bariatric surgery
a systematic review and meta-analysis
title Striatal dopamine D2-like receptors availability in obesity and its modulation by bariatric surgery
spellingShingle Striatal dopamine D2-like receptors availability in obesity and its modulation by bariatric surgery
Ribeiro, Gabriela
General
SDG 3 - Good Health and Well-being
title_short Striatal dopamine D2-like receptors availability in obesity and its modulation by bariatric surgery
title_full Striatal dopamine D2-like receptors availability in obesity and its modulation by bariatric surgery
title_fullStr Striatal dopamine D2-like receptors availability in obesity and its modulation by bariatric surgery
title_full_unstemmed Striatal dopamine D2-like receptors availability in obesity and its modulation by bariatric surgery
title_sort Striatal dopamine D2-like receptors availability in obesity and its modulation by bariatric surgery
author Ribeiro, Gabriela
author_facet Ribeiro, Gabriela
Maia, Ana
Cotovio, Gonçalo
Oliveira, Francisco P.M.
Costa, Durval C.
Oliveira-Maia, Albino J.
author_role author
author2 Maia, Ana
Cotovio, Gonçalo
Oliveira, Francisco P.M.
Costa, Durval C.
Oliveira-Maia, Albino J.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Ribeiro, Gabriela
Maia, Ana
Cotovio, Gonçalo
Oliveira, Francisco P.M.
Costa, Durval C.
Oliveira-Maia, Albino J.
dc.subject.por.fl_str_mv General
SDG 3 - Good Health and Well-being
topic General
SDG 3 - Good Health and Well-being
description OK
publishDate 2023
dc.date.none.fl_str_mv 2023-04-04T22:18:45Z
2023-03-27
2023-03-27T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/151587
url http://hdl.handle.net/10362/151587
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2045-2322
PURE: 57557045
https://doi.org/10.1038/s41598-023-31250-2
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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