Yeast chronological lifespan and proteotoxic stress : is autophagy good or bad
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/17433 |
Resumo: | Autophagy, a highly conserved proteolytic mechanism of quality control, is essential for the maintenance of metabolic and cellular homoeostasis and for an efficient cellular response to stress. Autophagy declines with aging and is believed to contribute to different aspects of the aging phenotype. The nutrient-sensing pathways PKA (protein kinase A), Sch9 and TOR (target of rapamycin), involved in the regulation of yeast lifespan, also converge on a common targeted process: autophagy. The molecular mechanisms underlying the regulation of autophagy and aging by these signalling pathways in yeast, with special attention to theTOR pathway, are discussed in the present paper. The question of whether or not autophagy could contribute to yeast cell death occurring during CLS (chronological lifespan) is discussed in the light of our findings obtained after autophagy activation promoted by proteotoxic stress. Autophagy progressively increases in cells expressing the aggregation-prone protein α-synuclein and seems to participate in the early cell death and shortening of CLS under these conditions, highlighting that autophagic activity should be maintained below physiological levels to exert its promising anti-aging effects. |
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Yeast chronological lifespan and proteotoxic stress : is autophagy good or badAutophagyChronological agingProteotoxic stressRas/cAMP dependent protein kinaseSch9Target of rapamycinRas/cAMP-dependent protein kinase (protein kinase A)target of rapamycin (TOR)Science & TechnologyAutophagy, a highly conserved proteolytic mechanism of quality control, is essential for the maintenance of metabolic and cellular homoeostasis and for an efficient cellular response to stress. Autophagy declines with aging and is believed to contribute to different aspects of the aging phenotype. The nutrient-sensing pathways PKA (protein kinase A), Sch9 and TOR (target of rapamycin), involved in the regulation of yeast lifespan, also converge on a common targeted process: autophagy. The molecular mechanisms underlying the regulation of autophagy and aging by these signalling pathways in yeast, with special attention to theTOR pathway, are discussed in the present paper. The question of whether or not autophagy could contribute to yeast cell death occurring during CLS (chronological lifespan) is discussed in the light of our findings obtained after autophagy activation promoted by proteotoxic stress. Autophagy progressively increases in cells expressing the aggregation-prone protein α-synuclein and seems to participate in the early cell death and shortening of CLS under these conditions, highlighting that autophagic activity should be maintained below physiological levels to exert its promising anti-aging effects.This work was supported by a grant from the Fundação para a Ciência e Tecnologia [grant number PTDC/BIA-MIC/114116/2009]; A.S. and B.S.M. received fellowships from the Fundação para a Ciência e Tecnologia [grant numbers SFRH/BD/33125/2007 and SRFH/BD/41674/2007 respectively].Biochemical SocietyUniversidade do MinhoSampaio-Marques, BelémFelgueiras, CarolinaSilva, AlexandraRodrigues, Fernando José dos SantosLudovico, Paula2011-102011-10-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/17433eng0300-512710.1042/BST039146621936835http://www.biochemsoctrans.org/bst/039/bst0391466.htminfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:02:30Zoai:repositorium.sdum.uminho.pt:1822/17433Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:52:29.354138Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Yeast chronological lifespan and proteotoxic stress : is autophagy good or bad |
title |
Yeast chronological lifespan and proteotoxic stress : is autophagy good or bad |
spellingShingle |
Yeast chronological lifespan and proteotoxic stress : is autophagy good or bad Sampaio-Marques, Belém Autophagy Chronological aging Proteotoxic stress Ras/cAMP dependent protein kinase Sch9 Target of rapamycin Ras/cAMP-dependent protein kinase (protein kinase A) target of rapamycin (TOR) Science & Technology |
title_short |
Yeast chronological lifespan and proteotoxic stress : is autophagy good or bad |
title_full |
Yeast chronological lifespan and proteotoxic stress : is autophagy good or bad |
title_fullStr |
Yeast chronological lifespan and proteotoxic stress : is autophagy good or bad |
title_full_unstemmed |
Yeast chronological lifespan and proteotoxic stress : is autophagy good or bad |
title_sort |
Yeast chronological lifespan and proteotoxic stress : is autophagy good or bad |
author |
Sampaio-Marques, Belém |
author_facet |
Sampaio-Marques, Belém Felgueiras, Carolina Silva, Alexandra Rodrigues, Fernando José dos Santos Ludovico, Paula |
author_role |
author |
author2 |
Felgueiras, Carolina Silva, Alexandra Rodrigues, Fernando José dos Santos Ludovico, Paula |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Sampaio-Marques, Belém Felgueiras, Carolina Silva, Alexandra Rodrigues, Fernando José dos Santos Ludovico, Paula |
dc.subject.por.fl_str_mv |
Autophagy Chronological aging Proteotoxic stress Ras/cAMP dependent protein kinase Sch9 Target of rapamycin Ras/cAMP-dependent protein kinase (protein kinase A) target of rapamycin (TOR) Science & Technology |
topic |
Autophagy Chronological aging Proteotoxic stress Ras/cAMP dependent protein kinase Sch9 Target of rapamycin Ras/cAMP-dependent protein kinase (protein kinase A) target of rapamycin (TOR) Science & Technology |
description |
Autophagy, a highly conserved proteolytic mechanism of quality control, is essential for the maintenance of metabolic and cellular homoeostasis and for an efficient cellular response to stress. Autophagy declines with aging and is believed to contribute to different aspects of the aging phenotype. The nutrient-sensing pathways PKA (protein kinase A), Sch9 and TOR (target of rapamycin), involved in the regulation of yeast lifespan, also converge on a common targeted process: autophagy. The molecular mechanisms underlying the regulation of autophagy and aging by these signalling pathways in yeast, with special attention to theTOR pathway, are discussed in the present paper. The question of whether or not autophagy could contribute to yeast cell death occurring during CLS (chronological lifespan) is discussed in the light of our findings obtained after autophagy activation promoted by proteotoxic stress. Autophagy progressively increases in cells expressing the aggregation-prone protein α-synuclein and seems to participate in the early cell death and shortening of CLS under these conditions, highlighting that autophagic activity should be maintained below physiological levels to exert its promising anti-aging effects. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-10 2011-10-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/17433 |
url |
http://hdl.handle.net/1822/17433 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0300-5127 10.1042/BST0391466 21936835 http://www.biochemsoctrans.org/bst/039/bst0391466.htm |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Biochemical Society |
publisher.none.fl_str_mv |
Biochemical Society |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799132301083279360 |