Potential use of chemoprotectants against the toxic effects of cyanotoxins: A review
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/10216/120467 |
Resumo: | Cyanobacterial toxins, particularly microcystins (MCs) and cylindrospermopsin (CYN), are responsible for toxic effects in humans and wildlife. In order to counteract or prevent their toxicity, various strategies have been followed, such as the potential application of chemoprotectants. A review of the main substances evaluated for this aim, as well as the doses and their influence on cyanotoxin-induced toxicity, has been performed. A search of the literature shows that research on MCs is much more abundant than research on CYN. Among chemoprotectants, antioxidant compounds are the most extensively studied, probably because it is well known that oxidative stress is one of the toxic mechanisms common to both toxins. In this group, vitamin E seems to have the strongest protectant effect for both cyanotoxins. Transport inhibitors have also been studied in the case of MCs, as CYN cellular uptake is not yet fully elucidated. Further research is needed because systematic studies are lacking. Moreover, more realistic exposure scenarios, including cyanotoxin mixtures and the concomitant use of chemoprotectants, should be considered. © 2017 by the authors. Licensee MDPI, Basel, Switzerland. |
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Potential use of chemoprotectants against the toxic effects of cyanotoxins: A reviewacetylcysteinealpha tocopherolamifostineascorbic acidaurantiinbacterial toxincarnitinecyanotoxincyclosporin Acylindrospermopsincysteinecytochalasinepigallocatechin gallateglutathionemelatoninmicrocystinosmotic agentrifampicinsilymarinsulforaphanethioctic acidtrolox Cunclassified drugheart failurehumanintoxicationliver hemorrhageliver injurynonhumanoxidative stressReviewtumor promotionCyanobacterial toxins, particularly microcystins (MCs) and cylindrospermopsin (CYN), are responsible for toxic effects in humans and wildlife. In order to counteract or prevent their toxicity, various strategies have been followed, such as the potential application of chemoprotectants. A review of the main substances evaluated for this aim, as well as the doses and their influence on cyanotoxin-induced toxicity, has been performed. A search of the literature shows that research on MCs is much more abundant than research on CYN. Among chemoprotectants, antioxidant compounds are the most extensively studied, probably because it is well known that oxidative stress is one of the toxic mechanisms common to both toxins. In this group, vitamin E seems to have the strongest protectant effect for both cyanotoxins. Transport inhibitors have also been studied in the case of MCs, as CYN cellular uptake is not yet fully elucidated. Further research is needed because systematic studies are lacking. Moreover, more realistic exposure scenarios, including cyanotoxin mixtures and the concomitant use of chemoprotectants, should be considered. © 2017 by the authors. Licensee MDPI, Basel, Switzerland.MDPI20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/120467eng2072665110.3390/toxins9060175Guzmán-Guillén R.Puerto M.Gutiérrez-Praena D.Prieto A.I.Pichardo S.Jos Á.Campos A.Vasconcelos V.Cameán A.M.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T14:51:14Zoai:repositorio-aberto.up.pt:10216/120467Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:10:05.214971Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Potential use of chemoprotectants against the toxic effects of cyanotoxins: A review |
title |
Potential use of chemoprotectants against the toxic effects of cyanotoxins: A review |
spellingShingle |
Potential use of chemoprotectants against the toxic effects of cyanotoxins: A review Guzmán-Guillén R. acetylcysteine alpha tocopherol amifostine ascorbic acid aurantiin bacterial toxin carnitine cyanotoxin cyclosporin A cylindrospermopsin cysteine cytochalasin epigallocatechin gallate glutathione melatonin microcystin osmotic agent rifampicin silymarin sulforaphane thioctic acid trolox C unclassified drug heart failure human intoxication liver hemorrhage liver injury nonhuman oxidative stress Review tumor promotion |
title_short |
Potential use of chemoprotectants against the toxic effects of cyanotoxins: A review |
title_full |
Potential use of chemoprotectants against the toxic effects of cyanotoxins: A review |
title_fullStr |
Potential use of chemoprotectants against the toxic effects of cyanotoxins: A review |
title_full_unstemmed |
Potential use of chemoprotectants against the toxic effects of cyanotoxins: A review |
title_sort |
Potential use of chemoprotectants against the toxic effects of cyanotoxins: A review |
author |
Guzmán-Guillén R. |
author_facet |
Guzmán-Guillén R. Puerto M. Gutiérrez-Praena D. Prieto A.I. Pichardo S. Jos Á. Campos A. Vasconcelos V. Cameán A.M. |
author_role |
author |
author2 |
Puerto M. Gutiérrez-Praena D. Prieto A.I. Pichardo S. Jos Á. Campos A. Vasconcelos V. Cameán A.M. |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Guzmán-Guillén R. Puerto M. Gutiérrez-Praena D. Prieto A.I. Pichardo S. Jos Á. Campos A. Vasconcelos V. Cameán A.M. |
dc.subject.por.fl_str_mv |
acetylcysteine alpha tocopherol amifostine ascorbic acid aurantiin bacterial toxin carnitine cyanotoxin cyclosporin A cylindrospermopsin cysteine cytochalasin epigallocatechin gallate glutathione melatonin microcystin osmotic agent rifampicin silymarin sulforaphane thioctic acid trolox C unclassified drug heart failure human intoxication liver hemorrhage liver injury nonhuman oxidative stress Review tumor promotion |
topic |
acetylcysteine alpha tocopherol amifostine ascorbic acid aurantiin bacterial toxin carnitine cyanotoxin cyclosporin A cylindrospermopsin cysteine cytochalasin epigallocatechin gallate glutathione melatonin microcystin osmotic agent rifampicin silymarin sulforaphane thioctic acid trolox C unclassified drug heart failure human intoxication liver hemorrhage liver injury nonhuman oxidative stress Review tumor promotion |
description |
Cyanobacterial toxins, particularly microcystins (MCs) and cylindrospermopsin (CYN), are responsible for toxic effects in humans and wildlife. In order to counteract or prevent their toxicity, various strategies have been followed, such as the potential application of chemoprotectants. A review of the main substances evaluated for this aim, as well as the doses and their influence on cyanotoxin-induced toxicity, has been performed. A search of the literature shows that research on MCs is much more abundant than research on CYN. Among chemoprotectants, antioxidant compounds are the most extensively studied, probably because it is well known that oxidative stress is one of the toxic mechanisms common to both toxins. In this group, vitamin E seems to have the strongest protectant effect for both cyanotoxins. Transport inhibitors have also been studied in the case of MCs, as CYN cellular uptake is not yet fully elucidated. Further research is needed because systematic studies are lacking. Moreover, more realistic exposure scenarios, including cyanotoxin mixtures and the concomitant use of chemoprotectants, should be considered. © 2017 by the authors. Licensee MDPI, Basel, Switzerland. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 2017-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/10216/120467 |
url |
https://hdl.handle.net/10216/120467 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
20726651 10.3390/toxins9060175 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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