2-Styrylchromones: novel strong scavengers of reactive oxygen and nitrogen species

Detalhes bibliográficos
Autor(a) principal: Gomes, Ana Sara
Data de Publicação: 2007
Outros Autores: Fernandes, Eduarda, Silva, Artur, Pinto, Diana, Santos, Clementina M.M., Cavaleiro, José, Lima, José Costa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10198/3922
Resumo: http://apps.isiknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=1&SID=S2NjaL1GBbk143plPl1&page=1&doc=1&colname=WOS
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spelling 2-Styrylchromones: novel strong scavengers of reactive oxygen and nitrogen species2-StyrylchromonesReactive oxygen speciesReactive nitrogen speciesScavenging activityAntioxidant activityhttp://apps.isiknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=1&SID=S2NjaL1GBbk143plPl1&page=1&doc=1&colname=WOS2-Styrylchromones are a small group of naturally occurring chromones, vinylogues of flavones (2-phenylchromones). Natural and synthetic 2-styrylchromones have been tested in different biological systems, showing activities with potential therapeutic applications. In particular, the potential and hitherto understudied antioxidant behavior of these compounds has been raised as a matter of interest. Thus the present work consisted in the study of the in vitro scavenging activities for reactive oxygen species (ROS) and reactive nitrogen species (RNS) of various 2-styrylchromone derivatives and structurally similar flavonoids. Some of the studied 2-styrylchromones proved to be extremely efficient scavengers of the different ROS and RNS, showing, in some cases, IC50s under 1 lM. The hydroxylation pattern of 2-styrylchromones, especially in the B-ring but also in the A ring, modulates the activity of these compounds, the catecholic derivatives being the most effective scavengers. The styryl pattern also contributes to their observed outstanding antioxidant activity. In conclusion, the scavenging activities for ROS/RNS of 2-styrylchromone derivatives, here shown for the first time, provide novel and most promising compounds to be applied as antioxidants.ElsevierBiblioteca Digital do IPBGomes, Ana SaraFernandes, EduardaSilva, ArturPinto, DianaSantos, Clementina M.M.Cavaleiro, JoséLima, José Costa2011-04-04T13:46:08Z20072007-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/3922engGomes, Ana; Fernandes, Eduarda; Silva, Artur; ; Santos, Clementina M.M.; Cavaleiro, José; Costa Lima, José (2007). 2-Styrylchromones: novel strong scavengers of reactive oxygen and nitrogen species. Bioorganic & Medicinal Chemistry. ISSN 0968-0896. 15:18, p. 6027-60360968-089610.1016/j.bmc.2007.06.046info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T10:08:21Zoai:bibliotecadigital.ipb.pt:10198/3922Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:56:08.520487Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv 2-Styrylchromones: novel strong scavengers of reactive oxygen and nitrogen species
title 2-Styrylchromones: novel strong scavengers of reactive oxygen and nitrogen species
spellingShingle 2-Styrylchromones: novel strong scavengers of reactive oxygen and nitrogen species
Gomes, Ana Sara
2-Styrylchromones
Reactive oxygen species
Reactive nitrogen species
Scavenging activity
Antioxidant activity
title_short 2-Styrylchromones: novel strong scavengers of reactive oxygen and nitrogen species
title_full 2-Styrylchromones: novel strong scavengers of reactive oxygen and nitrogen species
title_fullStr 2-Styrylchromones: novel strong scavengers of reactive oxygen and nitrogen species
title_full_unstemmed 2-Styrylchromones: novel strong scavengers of reactive oxygen and nitrogen species
title_sort 2-Styrylchromones: novel strong scavengers of reactive oxygen and nitrogen species
author Gomes, Ana Sara
author_facet Gomes, Ana Sara
Fernandes, Eduarda
Silva, Artur
Pinto, Diana
Santos, Clementina M.M.
Cavaleiro, José
Lima, José Costa
author_role author
author2 Fernandes, Eduarda
Silva, Artur
Pinto, Diana
Santos, Clementina M.M.
Cavaleiro, José
Lima, José Costa
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Biblioteca Digital do IPB
dc.contributor.author.fl_str_mv Gomes, Ana Sara
Fernandes, Eduarda
Silva, Artur
Pinto, Diana
Santos, Clementina M.M.
Cavaleiro, José
Lima, José Costa
dc.subject.por.fl_str_mv 2-Styrylchromones
Reactive oxygen species
Reactive nitrogen species
Scavenging activity
Antioxidant activity
topic 2-Styrylchromones
Reactive oxygen species
Reactive nitrogen species
Scavenging activity
Antioxidant activity
description http://apps.isiknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=1&SID=S2NjaL1GBbk143plPl1&page=1&doc=1&colname=WOS
publishDate 2007
dc.date.none.fl_str_mv 2007
2007-01-01T00:00:00Z
2011-04-04T13:46:08Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10198/3922
url http://hdl.handle.net/10198/3922
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Gomes, Ana; Fernandes, Eduarda; Silva, Artur; ; Santos, Clementina M.M.; Cavaleiro, José; Costa Lima, José (2007). 2-Styrylchromones: novel strong scavengers of reactive oxygen and nitrogen species. Bioorganic & Medicinal Chemistry. ISSN 0968-0896. 15:18, p. 6027-6036
0968-0896
10.1016/j.bmc.2007.06.046
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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