EULAR study group on MHC-I-opathy: identifying disease-overarching mechanisms across disciplines and borders
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/58651 |
Resumo: | © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
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EULAR study group on MHC-I-opathy: identifying disease-overarching mechanisms across disciplines and bordersArthritis, PsoriaticBehcet SyndromeImmune System DiseasesSpondylitis, Ankylosing© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.The 'MHC-I (major histocompatibility complex class I)-opathy' concept describes a family of inflammatory conditions with overlapping clinical manifestations and a strong genetic link to the MHC-I antigen presentation pathway. Classical MHC-I-opathies such as spondyloarthritis, Behçet's disease, psoriasis and birdshot uveitis are widely recognised for their strong association with certain MHC-I alleles and gene variants of the antigen processing aminopeptidases ERAP1 and ERAP2 that implicates altered MHC-I peptide presentation to CD8+T cells in the pathogenesis. Progress in understanding the cause and treatment of these disorders is hampered by patient phenotypic heterogeneity and lack of systematic investigation of the MHC-I pathway.Here, we discuss new insights into the biology of MHC-I-opathies that strongly advocate for disease-overarching and integrated molecular and clinical investigation to decipher underlying disease mechanisms. Because this requires transformative multidisciplinary collaboration, we introduce the EULAR study group on MHC-I-opathies to unite clinical expertise in rheumatology, dermatology and ophthalmology, with fundamental and translational researchers from multiple disciplines such as immunology, genomics and proteomics, alongside patient partners. We prioritise standardisation of disease phenotypes and scientific nomenclature and propose interdisciplinary genetic and translational studies to exploit emerging therapeutic strategies to understand MHC-I-mediated disease mechanisms. These collaborative efforts are required to address outstanding questions in the etiopathogenesis of MHC-I-opathies towards improving patient treatment and prognostication.BMJ Publishing GroupRepositório da Universidade de LisboaKuiper, Jonas J. W.Prinz, Jörg C.Stratikos, EfstratiosKuśnierczyk, PiotrArakawa, AkikoSpringer, SebastianMintoff, DillonPadjen, IvanShumnalieva, RusskaVural, SeçilKötter, Inavan de Sande, Marleen G.Boyvat, Ayşede Boer, Joke H.Bertsias, Georgede Vries, NiekKrieckaert, Charlotte L. M.Leal, InesVidovič Valentinčič, NatašaTugal-Tutkun, Ilknurel Khaldi Ahanach, HananeCostantino, FélicieGlatigny, SimonMrazovac Zimak, DanijelaLötscher, FabianKerstens, Floor G.Bakula, MarijaVieira De Sousa, Elsa CristinaBöhm, PeterBosman, KeesKenna, Tony J.Powis, Simon J.Breban, MaximeGul, AhmetBowes, JohnLories, Rik J. U.Nowatzky, JohannesWolbink, Gerrit JanMcGonagle, Dennis G.Turkstra, Franktien2023-07-18T11:35:30Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/58651engAnn Rheum Dis . 2023 Jul;82(7):887-8960003-496710.1136/ard-2022-2228521468-2060info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:07:13Zoai:repositorio.ul.pt:10451/58651Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:08:39.799548Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
EULAR study group on MHC-I-opathy: identifying disease-overarching mechanisms across disciplines and borders |
title |
EULAR study group on MHC-I-opathy: identifying disease-overarching mechanisms across disciplines and borders |
spellingShingle |
EULAR study group on MHC-I-opathy: identifying disease-overarching mechanisms across disciplines and borders Kuiper, Jonas J. W. Arthritis, Psoriatic Behcet Syndrome Immune System Diseases Spondylitis, Ankylosing |
title_short |
EULAR study group on MHC-I-opathy: identifying disease-overarching mechanisms across disciplines and borders |
title_full |
EULAR study group on MHC-I-opathy: identifying disease-overarching mechanisms across disciplines and borders |
title_fullStr |
EULAR study group on MHC-I-opathy: identifying disease-overarching mechanisms across disciplines and borders |
title_full_unstemmed |
EULAR study group on MHC-I-opathy: identifying disease-overarching mechanisms across disciplines and borders |
title_sort |
EULAR study group on MHC-I-opathy: identifying disease-overarching mechanisms across disciplines and borders |
author |
Kuiper, Jonas J. W. |
author_facet |
Kuiper, Jonas J. W. Prinz, Jörg C. Stratikos, Efstratios Kuśnierczyk, Piotr Arakawa, Akiko Springer, Sebastian Mintoff, Dillon Padjen, Ivan Shumnalieva, Russka Vural, Seçil Kötter, Ina van de Sande, Marleen G. Boyvat, Ayşe de Boer, Joke H. Bertsias, George de Vries, Niek Krieckaert, Charlotte L. M. Leal, Ines Vidovič Valentinčič, Nataša Tugal-Tutkun, Ilknur el Khaldi Ahanach, Hanane Costantino, Félicie Glatigny, Simon Mrazovac Zimak, Danijela Lötscher, Fabian Kerstens, Floor G. Bakula, Marija Vieira De Sousa, Elsa Cristina Böhm, Peter Bosman, Kees Kenna, Tony J. Powis, Simon J. Breban, Maxime Gul, Ahmet Bowes, John Lories, Rik J. U. Nowatzky, Johannes Wolbink, Gerrit Jan McGonagle, Dennis G. Turkstra, Franktien |
author_role |
author |
author2 |
Prinz, Jörg C. Stratikos, Efstratios Kuśnierczyk, Piotr Arakawa, Akiko Springer, Sebastian Mintoff, Dillon Padjen, Ivan Shumnalieva, Russka Vural, Seçil Kötter, Ina van de Sande, Marleen G. Boyvat, Ayşe de Boer, Joke H. Bertsias, George de Vries, Niek Krieckaert, Charlotte L. M. Leal, Ines Vidovič Valentinčič, Nataša Tugal-Tutkun, Ilknur el Khaldi Ahanach, Hanane Costantino, Félicie Glatigny, Simon Mrazovac Zimak, Danijela Lötscher, Fabian Kerstens, Floor G. Bakula, Marija Vieira De Sousa, Elsa Cristina Böhm, Peter Bosman, Kees Kenna, Tony J. Powis, Simon J. Breban, Maxime Gul, Ahmet Bowes, John Lories, Rik J. U. Nowatzky, Johannes Wolbink, Gerrit Jan McGonagle, Dennis G. Turkstra, Franktien |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Kuiper, Jonas J. W. Prinz, Jörg C. Stratikos, Efstratios Kuśnierczyk, Piotr Arakawa, Akiko Springer, Sebastian Mintoff, Dillon Padjen, Ivan Shumnalieva, Russka Vural, Seçil Kötter, Ina van de Sande, Marleen G. Boyvat, Ayşe de Boer, Joke H. Bertsias, George de Vries, Niek Krieckaert, Charlotte L. M. Leal, Ines Vidovič Valentinčič, Nataša Tugal-Tutkun, Ilknur el Khaldi Ahanach, Hanane Costantino, Félicie Glatigny, Simon Mrazovac Zimak, Danijela Lötscher, Fabian Kerstens, Floor G. Bakula, Marija Vieira De Sousa, Elsa Cristina Böhm, Peter Bosman, Kees Kenna, Tony J. Powis, Simon J. Breban, Maxime Gul, Ahmet Bowes, John Lories, Rik J. U. Nowatzky, Johannes Wolbink, Gerrit Jan McGonagle, Dennis G. Turkstra, Franktien |
dc.subject.por.fl_str_mv |
Arthritis, Psoriatic Behcet Syndrome Immune System Diseases Spondylitis, Ankylosing |
topic |
Arthritis, Psoriatic Behcet Syndrome Immune System Diseases Spondylitis, Ankylosing |
description |
© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-07-18T11:35:30Z 2023 2023-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/58651 |
url |
http://hdl.handle.net/10451/58651 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Ann Rheum Dis . 2023 Jul;82(7):887-896 0003-4967 10.1136/ard-2022-222852 1468-2060 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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BMJ Publishing Group |
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BMJ Publishing Group |
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