EULAR study group on MHC-I-opathy: identifying disease-overarching mechanisms across disciplines and borders

Detalhes bibliográficos
Autor(a) principal: Kuiper, Jonas J. W.
Data de Publicação: 2023
Outros Autores: Prinz, Jörg C., Stratikos, Efstratios, Kuśnierczyk, Piotr, Arakawa, Akiko, Springer, Sebastian, Mintoff, Dillon, Padjen, Ivan, Shumnalieva, Russka, Vural, Seçil, Kötter, Ina, van de Sande, Marleen G., Boyvat, Ayşe, de Boer, Joke H., Bertsias, George, de Vries, Niek, Krieckaert, Charlotte L. M., Leal, Ines, Vidovič Valentinčič, Nataša, Tugal-Tutkun, Ilknur, el Khaldi Ahanach, Hanane, Costantino, Félicie, Glatigny, Simon, Mrazovac Zimak, Danijela, Lötscher, Fabian, Kerstens, Floor G., Bakula, Marija, Vieira De Sousa, Elsa Cristina, Böhm, Peter, Bosman, Kees, Kenna, Tony J., Powis, Simon J., Breban, Maxime, Gul, Ahmet, Bowes, John, Lories, Rik J. U., Nowatzky, Johannes, Wolbink, Gerrit Jan, McGonagle, Dennis G., Turkstra, Franktien
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/58651
Resumo: © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
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spelling EULAR study group on MHC-I-opathy: identifying disease-overarching mechanisms across disciplines and bordersArthritis, PsoriaticBehcet SyndromeImmune System DiseasesSpondylitis, Ankylosing© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.The 'MHC-I (major histocompatibility complex class I)-opathy' concept describes a family of inflammatory conditions with overlapping clinical manifestations and a strong genetic link to the MHC-I antigen presentation pathway. Classical MHC-I-opathies such as spondyloarthritis, Behçet's disease, psoriasis and birdshot uveitis are widely recognised for their strong association with certain MHC-I alleles and gene variants of the antigen processing aminopeptidases ERAP1 and ERAP2 that implicates altered MHC-I peptide presentation to CD8+T cells in the pathogenesis. Progress in understanding the cause and treatment of these disorders is hampered by patient phenotypic heterogeneity and lack of systematic investigation of the MHC-I pathway.Here, we discuss new insights into the biology of MHC-I-opathies that strongly advocate for disease-overarching and integrated molecular and clinical investigation to decipher underlying disease mechanisms. Because this requires transformative multidisciplinary collaboration, we introduce the EULAR study group on MHC-I-opathies to unite clinical expertise in rheumatology, dermatology and ophthalmology, with fundamental and translational researchers from multiple disciplines such as immunology, genomics and proteomics, alongside patient partners. We prioritise standardisation of disease phenotypes and scientific nomenclature and propose interdisciplinary genetic and translational studies to exploit emerging therapeutic strategies to understand MHC-I-mediated disease mechanisms. These collaborative efforts are required to address outstanding questions in the etiopathogenesis of MHC-I-opathies towards improving patient treatment and prognostication.BMJ Publishing GroupRepositório da Universidade de LisboaKuiper, Jonas J. W.Prinz, Jörg C.Stratikos, EfstratiosKuśnierczyk, PiotrArakawa, AkikoSpringer, SebastianMintoff, DillonPadjen, IvanShumnalieva, RusskaVural, SeçilKötter, Inavan de Sande, Marleen G.Boyvat, Ayşede Boer, Joke H.Bertsias, Georgede Vries, NiekKrieckaert, Charlotte L. M.Leal, InesVidovič Valentinčič, NatašaTugal-Tutkun, Ilknurel Khaldi Ahanach, HananeCostantino, FélicieGlatigny, SimonMrazovac Zimak, DanijelaLötscher, FabianKerstens, Floor G.Bakula, MarijaVieira De Sousa, Elsa CristinaBöhm, PeterBosman, KeesKenna, Tony J.Powis, Simon J.Breban, MaximeGul, AhmetBowes, JohnLories, Rik J. U.Nowatzky, JohannesWolbink, Gerrit JanMcGonagle, Dennis G.Turkstra, Franktien2023-07-18T11:35:30Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/58651engAnn Rheum Dis . 2023 Jul;82(7):887-8960003-496710.1136/ard-2022-2228521468-2060info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:07:13Zoai:repositorio.ul.pt:10451/58651Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:08:39.799548Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv EULAR study group on MHC-I-opathy: identifying disease-overarching mechanisms across disciplines and borders
title EULAR study group on MHC-I-opathy: identifying disease-overarching mechanisms across disciplines and borders
spellingShingle EULAR study group on MHC-I-opathy: identifying disease-overarching mechanisms across disciplines and borders
Kuiper, Jonas J. W.
Arthritis, Psoriatic
Behcet Syndrome
Immune System Diseases
Spondylitis, Ankylosing
title_short EULAR study group on MHC-I-opathy: identifying disease-overarching mechanisms across disciplines and borders
title_full EULAR study group on MHC-I-opathy: identifying disease-overarching mechanisms across disciplines and borders
title_fullStr EULAR study group on MHC-I-opathy: identifying disease-overarching mechanisms across disciplines and borders
title_full_unstemmed EULAR study group on MHC-I-opathy: identifying disease-overarching mechanisms across disciplines and borders
title_sort EULAR study group on MHC-I-opathy: identifying disease-overarching mechanisms across disciplines and borders
author Kuiper, Jonas J. W.
author_facet Kuiper, Jonas J. W.
Prinz, Jörg C.
Stratikos, Efstratios
Kuśnierczyk, Piotr
Arakawa, Akiko
Springer, Sebastian
Mintoff, Dillon
Padjen, Ivan
Shumnalieva, Russka
Vural, Seçil
Kötter, Ina
van de Sande, Marleen G.
Boyvat, Ayşe
de Boer, Joke H.
Bertsias, George
de Vries, Niek
Krieckaert, Charlotte L. M.
Leal, Ines
Vidovič Valentinčič, Nataša
Tugal-Tutkun, Ilknur
el Khaldi Ahanach, Hanane
Costantino, Félicie
Glatigny, Simon
Mrazovac Zimak, Danijela
Lötscher, Fabian
Kerstens, Floor G.
Bakula, Marija
Vieira De Sousa, Elsa Cristina
Böhm, Peter
Bosman, Kees
Kenna, Tony J.
Powis, Simon J.
Breban, Maxime
Gul, Ahmet
Bowes, John
Lories, Rik J. U.
Nowatzky, Johannes
Wolbink, Gerrit Jan
McGonagle, Dennis G.
Turkstra, Franktien
author_role author
author2 Prinz, Jörg C.
Stratikos, Efstratios
Kuśnierczyk, Piotr
Arakawa, Akiko
Springer, Sebastian
Mintoff, Dillon
Padjen, Ivan
Shumnalieva, Russka
Vural, Seçil
Kötter, Ina
van de Sande, Marleen G.
Boyvat, Ayşe
de Boer, Joke H.
Bertsias, George
de Vries, Niek
Krieckaert, Charlotte L. M.
Leal, Ines
Vidovič Valentinčič, Nataša
Tugal-Tutkun, Ilknur
el Khaldi Ahanach, Hanane
Costantino, Félicie
Glatigny, Simon
Mrazovac Zimak, Danijela
Lötscher, Fabian
Kerstens, Floor G.
Bakula, Marija
Vieira De Sousa, Elsa Cristina
Böhm, Peter
Bosman, Kees
Kenna, Tony J.
Powis, Simon J.
Breban, Maxime
Gul, Ahmet
Bowes, John
Lories, Rik J. U.
Nowatzky, Johannes
Wolbink, Gerrit Jan
McGonagle, Dennis G.
Turkstra, Franktien
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Kuiper, Jonas J. W.
Prinz, Jörg C.
Stratikos, Efstratios
Kuśnierczyk, Piotr
Arakawa, Akiko
Springer, Sebastian
Mintoff, Dillon
Padjen, Ivan
Shumnalieva, Russka
Vural, Seçil
Kötter, Ina
van de Sande, Marleen G.
Boyvat, Ayşe
de Boer, Joke H.
Bertsias, George
de Vries, Niek
Krieckaert, Charlotte L. M.
Leal, Ines
Vidovič Valentinčič, Nataša
Tugal-Tutkun, Ilknur
el Khaldi Ahanach, Hanane
Costantino, Félicie
Glatigny, Simon
Mrazovac Zimak, Danijela
Lötscher, Fabian
Kerstens, Floor G.
Bakula, Marija
Vieira De Sousa, Elsa Cristina
Böhm, Peter
Bosman, Kees
Kenna, Tony J.
Powis, Simon J.
Breban, Maxime
Gul, Ahmet
Bowes, John
Lories, Rik J. U.
Nowatzky, Johannes
Wolbink, Gerrit Jan
McGonagle, Dennis G.
Turkstra, Franktien
dc.subject.por.fl_str_mv Arthritis, Psoriatic
Behcet Syndrome
Immune System Diseases
Spondylitis, Ankylosing
topic Arthritis, Psoriatic
Behcet Syndrome
Immune System Diseases
Spondylitis, Ankylosing
description © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
publishDate 2023
dc.date.none.fl_str_mv 2023-07-18T11:35:30Z
2023
2023-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/58651
url http://hdl.handle.net/10451/58651
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Ann Rheum Dis . 2023 Jul;82(7):887-896
0003-4967
10.1136/ard-2022-222852
1468-2060
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMJ Publishing Group
publisher.none.fl_str_mv BMJ Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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