Potential drug targets in the pentose phosphate pathway of trypanosomatids

Detalhes bibliográficos
Autor(a) principal: Loureiro, I
Data de Publicação: 2018
Outros Autores: Faria, J, Santarem, N, Smith, TK, Tavares, J, Cordeiro-da-Silva, A
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://repositorio-aberto.up.pt/handle/10216/118200
Resumo: The trypanosomatids, Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp, are causative agents of important human diseases such African sleeping sickness, Chagas' disease and Leishmaniasis, respectively. The high impact of these diseases on human health and economy worldwide, the unsatisfactory available chemotherapeutic options and the absence of human effective vaccines, strongly justifies the search for new drugs. The pentose phosphate pathway has been proposed to be a viable strategy to defeat several infectious diseases, including those from trypanosomatids, as it includes an oxidative branch, important in the maintenance of cell redox homeostasis, and a non-oxidative branch in which ribose 5-phosphate and erythrose 4-phosphate, precursors of nucleic acids and aromatic amino acids, are produced. This review provides an overview of the available chemotherapeutic options against these diseases and discusses the potential of genetically validated enzymes from the pentose phosphate pathway of trypanosomatids to be explored as potential drug targets.
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spelling Potential drug targets in the pentose phosphate pathway of trypanosomatidsDrug targetsPentose phosphate pathwayTreatmentTrypanosomatidsThe trypanosomatids, Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp, are causative agents of important human diseases such African sleeping sickness, Chagas' disease and Leishmaniasis, respectively. The high impact of these diseases on human health and economy worldwide, the unsatisfactory available chemotherapeutic options and the absence of human effective vaccines, strongly justifies the search for new drugs. The pentose phosphate pathway has been proposed to be a viable strategy to defeat several infectious diseases, including those from trypanosomatids, as it includes an oxidative branch, important in the maintenance of cell redox homeostasis, and a non-oxidative branch in which ribose 5-phosphate and erythrose 4-phosphate, precursors of nucleic acids and aromatic amino acids, are produced. This review provides an overview of the available chemotherapeutic options against these diseases and discusses the potential of genetically validated enzymes from the pentose phosphate pathway of trypanosomatids to be explored as potential drug targets.Bentham Science Publishers20182018-01-01T00:00:00Z2019-12-31T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://repositorio-aberto.up.pt/handle/10216/118200eng0929-867310.2174/0929867325666171206094752Loureiro, IFaria, JSantarem, NSmith, TKTavares, JCordeiro-da-Silva, Ainfo:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-09-27T06:52:14Zoai:repositorio-aberto.up.pt:10216/118200Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-09-27T06:52:14Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Potential drug targets in the pentose phosphate pathway of trypanosomatids
title Potential drug targets in the pentose phosphate pathway of trypanosomatids
spellingShingle Potential drug targets in the pentose phosphate pathway of trypanosomatids
Loureiro, I
Drug targets
Pentose phosphate pathway
Treatment
Trypanosomatids
title_short Potential drug targets in the pentose phosphate pathway of trypanosomatids
title_full Potential drug targets in the pentose phosphate pathway of trypanosomatids
title_fullStr Potential drug targets in the pentose phosphate pathway of trypanosomatids
title_full_unstemmed Potential drug targets in the pentose phosphate pathway of trypanosomatids
title_sort Potential drug targets in the pentose phosphate pathway of trypanosomatids
author Loureiro, I
author_facet Loureiro, I
Faria, J
Santarem, N
Smith, TK
Tavares, J
Cordeiro-da-Silva, A
author_role author
author2 Faria, J
Santarem, N
Smith, TK
Tavares, J
Cordeiro-da-Silva, A
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Loureiro, I
Faria, J
Santarem, N
Smith, TK
Tavares, J
Cordeiro-da-Silva, A
dc.subject.por.fl_str_mv Drug targets
Pentose phosphate pathway
Treatment
Trypanosomatids
topic Drug targets
Pentose phosphate pathway
Treatment
Trypanosomatids
description The trypanosomatids, Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp, are causative agents of important human diseases such African sleeping sickness, Chagas' disease and Leishmaniasis, respectively. The high impact of these diseases on human health and economy worldwide, the unsatisfactory available chemotherapeutic options and the absence of human effective vaccines, strongly justifies the search for new drugs. The pentose phosphate pathway has been proposed to be a viable strategy to defeat several infectious diseases, including those from trypanosomatids, as it includes an oxidative branch, important in the maintenance of cell redox homeostasis, and a non-oxidative branch in which ribose 5-phosphate and erythrose 4-phosphate, precursors of nucleic acids and aromatic amino acids, are produced. This review provides an overview of the available chemotherapeutic options against these diseases and discusses the potential of genetically validated enzymes from the pentose phosphate pathway of trypanosomatids to be explored as potential drug targets.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
2019-12-31T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://repositorio-aberto.up.pt/handle/10216/118200
url https://repositorio-aberto.up.pt/handle/10216/118200
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0929-8673
10.2174/0929867325666171206094752
dc.rights.driver.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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