Highly dynamic host actin reorganization around developing Plasmodium inside hepatocytes

Detalhes bibliográficos
Autor(a) principal: Gomes Santos, Carina S. S.
Data de Publicação: 2012
Outros Autores: Itoe, Maurice, Afonso, Cristina, Henriques, Ricardo, Gardner, Rui, Sepulveda, Nuno, Simões, Pedro D., Raquel, Maria Helena, Almeida, António Paulo, Moita, Luis, Frischknecht, Friedrich, Mota, Maria M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/50218
Resumo: © 2012 Gomes-Santos et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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spelling Highly dynamic host actin reorganization around developing Plasmodium inside hepatocytes© 2012 Gomes-Santos et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Plasmodium sporozoites are transmitted by Anopheles mosquitoes and infect hepatocytes, where a single sporozoite replicates into thousands of merozoites inside a parasitophorous vacuole. The nature of the Plasmodium-host cell interface, as well as the interactions occurring between these two organisms, remains largely unknown. Here we show that highly dynamic hepatocyte actin reorganization events occur around developing Plasmodium berghei parasites inside human hepatoma cells. Actin reorganization is most prominent between 10 to 16 hours post infection and depends on the actin severing and capping protein, gelsolin. Live cell imaging studies also suggest that the hepatocyte cytoskeleton may contribute to parasite elimination during Plasmodium development in the liver.The work was supported by Fundação para a Ciência e Tecnologia (FCT) of the Portuguese Ministry of Science (PTDC/SAU-GMG/100313/2008), the Federal German Ministry of education and Science (Biofuture) C.S.S.G-S. was supported by an FCT fellowship (SFRH/BD/15888/2005). M.A.I. was funded by the EU FP 7 Marie Curie Initial Training Network ‘‘Intervention Strategies against Malaria (InterMalTraining)’’, contract no. 215281. L.F.M. is a Young Investigator from the Human Frontier Science Program and receives support from Fundação Luso-Americana para o Desenvolvimento and Fundação para a Ciência e a Tecnologia (PTDC/SAU-MII/69280/2006 and PTDC/SAU-MII/78333/2006). F.F. thanks the Chica and Heinz Schaller Foundation for support. M.M.M. and F.F. are members of the EU FP7 Network of Excellence EVIMalaRPLOSRepositório da Universidade de LisboaGomes Santos, Carina S. S.Itoe, MauriceAfonso, CristinaHenriques, RicardoGardner, RuiSepulveda, NunoSimões, Pedro D.Raquel, Maria HelenaAlmeida, António PauloMoita, LuisFrischknecht, FriedrichMota, Maria M.2021-11-30T12:29:58Z20122012-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/50218engGomes-Santos CS, Itoe MA, Afonso C, Henriques R, Gardner R, Sepúlveda N, Simões PD, Raquel H, Almeida AP, Moita LF, Frischknecht F, Mota MM. Highly dynamic host actin reorganization around developing Plasmodium inside hepatocytes. PLoS One. 2012;7(1):e29408.10.1371/journal.pone.00294081932-6203info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:54:10Zoai:repositorio.ul.pt:10451/50218Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:01:37.067553Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Highly dynamic host actin reorganization around developing Plasmodium inside hepatocytes
title Highly dynamic host actin reorganization around developing Plasmodium inside hepatocytes
spellingShingle Highly dynamic host actin reorganization around developing Plasmodium inside hepatocytes
Gomes Santos, Carina S. S.
title_short Highly dynamic host actin reorganization around developing Plasmodium inside hepatocytes
title_full Highly dynamic host actin reorganization around developing Plasmodium inside hepatocytes
title_fullStr Highly dynamic host actin reorganization around developing Plasmodium inside hepatocytes
title_full_unstemmed Highly dynamic host actin reorganization around developing Plasmodium inside hepatocytes
title_sort Highly dynamic host actin reorganization around developing Plasmodium inside hepatocytes
author Gomes Santos, Carina S. S.
author_facet Gomes Santos, Carina S. S.
Itoe, Maurice
Afonso, Cristina
Henriques, Ricardo
Gardner, Rui
Sepulveda, Nuno
Simões, Pedro D.
Raquel, Maria Helena
Almeida, António Paulo
Moita, Luis
Frischknecht, Friedrich
Mota, Maria M.
author_role author
author2 Itoe, Maurice
Afonso, Cristina
Henriques, Ricardo
Gardner, Rui
Sepulveda, Nuno
Simões, Pedro D.
Raquel, Maria Helena
Almeida, António Paulo
Moita, Luis
Frischknecht, Friedrich
Mota, Maria M.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Gomes Santos, Carina S. S.
Itoe, Maurice
Afonso, Cristina
Henriques, Ricardo
Gardner, Rui
Sepulveda, Nuno
Simões, Pedro D.
Raquel, Maria Helena
Almeida, António Paulo
Moita, Luis
Frischknecht, Friedrich
Mota, Maria M.
description © 2012 Gomes-Santos et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
publishDate 2012
dc.date.none.fl_str_mv 2012
2012-01-01T00:00:00Z
2021-11-30T12:29:58Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/50218
url http://hdl.handle.net/10451/50218
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Gomes-Santos CS, Itoe MA, Afonso C, Henriques R, Gardner R, Sepúlveda N, Simões PD, Raquel H, Almeida AP, Moita LF, Frischknecht F, Mota MM. Highly dynamic host actin reorganization around developing Plasmodium inside hepatocytes. PLoS One. 2012;7(1):e29408.
10.1371/journal.pone.0029408
1932-6203
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv PLOS
publisher.none.fl_str_mv PLOS
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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