Essential oils from coa valley lamiaceae species: cytotoxicity and antiproliferative effect on glioblastoma cells
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10198/15905 |
Resumo: | Lavandula pedunculata (Mill.) Cav., Mentha cervina L. and Thymus mastichina (L.) L. subsp. mastichina are representative species of the Coa Valley's flora, a Portuguese UNESCO World Heritage Site. L. pedunculata and T. mastichina are traditionally used to preserve olives and to aromatize bonfires on Saint John's Eve, while M. cervina is mainly used as a spice for river fish dishes. Despite their traditional uses, these aromatic plants are still undervalued, and literature regarding their bioactivity, especially anticancer, is scarce. In this work, the morphology of secretory structures was assessed by scanning electron microscopy (SEM), and the composition of essential oils (EOs) was characterized by gas chromatography-mass spectrometry (GC-MS). The study proceeded with cytotoxic evaluation of EOs in tumor and non-tumor cells with the cell death mechanism explored in glioblastoma (GB) cells. L. pedunculata EO presented the most pronounced cytotoxic/antiproliferative activity against tumor cells, with moderate cytotoxicity against non-tumor cells. Whereas, M. cervina EO exhibited a slightly lower cytotoxic effect against tumor cells and did not affect the viability of non-tumor cells. Meanwhile, T. mastichina EO did not induce a strong cytotoxic effect against GB cells. L. pedunculata and M. cervina EOs lead to cell death by inducing apoptosis in a dose-dependent manner. The present study suggests that L. pedunculata and M. cervina EOs have a strong cytotoxic and antiproliferative potential to be further studied as efficient antitumor agents. |
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Essential oils from coa valley lamiaceae species: cytotoxicity and antiproliferative effect on glioblastoma cellsEssential oilsLavandula pedunculataMentha cervinaThymus mastichina subsp. mastichinaCôa ValleyCytotoxicityGlioblastomaLavandula pedunculata (Mill.) Cav., Mentha cervina L. and Thymus mastichina (L.) L. subsp. mastichina are representative species of the Coa Valley's flora, a Portuguese UNESCO World Heritage Site. L. pedunculata and T. mastichina are traditionally used to preserve olives and to aromatize bonfires on Saint John's Eve, while M. cervina is mainly used as a spice for river fish dishes. Despite their traditional uses, these aromatic plants are still undervalued, and literature regarding their bioactivity, especially anticancer, is scarce. In this work, the morphology of secretory structures was assessed by scanning electron microscopy (SEM), and the composition of essential oils (EOs) was characterized by gas chromatography-mass spectrometry (GC-MS). The study proceeded with cytotoxic evaluation of EOs in tumor and non-tumor cells with the cell death mechanism explored in glioblastoma (GB) cells. L. pedunculata EO presented the most pronounced cytotoxic/antiproliferative activity against tumor cells, with moderate cytotoxicity against non-tumor cells. Whereas, M. cervina EO exhibited a slightly lower cytotoxic effect against tumor cells and did not affect the viability of non-tumor cells. Meanwhile, T. mastichina EO did not induce a strong cytotoxic effect against GB cells. L. pedunculata and M. cervina EOs lead to cell death by inducing apoptosis in a dose-dependent manner. The present study suggests that L. pedunculata and M. cervina EOs have a strong cytotoxic and antiproliferative potential to be further studied as efficient antitumor agents.MDPIBiblioteca Digital do IPBMarques, Mário P.Neves, Beatriz GuapoVarela, CarlaZuzarte, MónicaGoncalves, Ana CristinaDias, Maria InêsAmaral, Joana S.Barros, LillianMagalhães, MarianaCabral, Célia2018-02-21T16:27:17Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/15905engMarques, Mário P.; Neves, Beatriz Guapo; Varela, Carla; Zuzarte, Mónica; Goncalves, Ana Cristina; Dias, Maria Inês; Amaral, Joana S.; Barros, Lillian; Magalhães, Mariana; Cabral, Célia (2023). Essential oils from coa valley lamiaceae species: cytotoxicity and antiproliferative effect on glioblastoma cells. Pharmaceutics. eISSN 1999-4923. 15:2, p. 1-1810.3390/pharmaceutics150203411999-4923info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-07T01:18:08Zoai:bibliotecadigital.ipb.pt:10198/15905Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:05:14.102128Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Essential oils from coa valley lamiaceae species: cytotoxicity and antiproliferative effect on glioblastoma cells |
title |
Essential oils from coa valley lamiaceae species: cytotoxicity and antiproliferative effect on glioblastoma cells |
spellingShingle |
Essential oils from coa valley lamiaceae species: cytotoxicity and antiproliferative effect on glioblastoma cells Marques, Mário P. Essential oils Lavandula pedunculata Mentha cervina Thymus mastichina subsp. mastichina Côa Valley Cytotoxicity Glioblastoma |
title_short |
Essential oils from coa valley lamiaceae species: cytotoxicity and antiproliferative effect on glioblastoma cells |
title_full |
Essential oils from coa valley lamiaceae species: cytotoxicity and antiproliferative effect on glioblastoma cells |
title_fullStr |
Essential oils from coa valley lamiaceae species: cytotoxicity and antiproliferative effect on glioblastoma cells |
title_full_unstemmed |
Essential oils from coa valley lamiaceae species: cytotoxicity and antiproliferative effect on glioblastoma cells |
title_sort |
Essential oils from coa valley lamiaceae species: cytotoxicity and antiproliferative effect on glioblastoma cells |
author |
Marques, Mário P. |
author_facet |
Marques, Mário P. Neves, Beatriz Guapo Varela, Carla Zuzarte, Mónica Goncalves, Ana Cristina Dias, Maria Inês Amaral, Joana S. Barros, Lillian Magalhães, Mariana Cabral, Célia |
author_role |
author |
author2 |
Neves, Beatriz Guapo Varela, Carla Zuzarte, Mónica Goncalves, Ana Cristina Dias, Maria Inês Amaral, Joana S. Barros, Lillian Magalhães, Mariana Cabral, Célia |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Biblioteca Digital do IPB |
dc.contributor.author.fl_str_mv |
Marques, Mário P. Neves, Beatriz Guapo Varela, Carla Zuzarte, Mónica Goncalves, Ana Cristina Dias, Maria Inês Amaral, Joana S. Barros, Lillian Magalhães, Mariana Cabral, Célia |
dc.subject.por.fl_str_mv |
Essential oils Lavandula pedunculata Mentha cervina Thymus mastichina subsp. mastichina Côa Valley Cytotoxicity Glioblastoma |
topic |
Essential oils Lavandula pedunculata Mentha cervina Thymus mastichina subsp. mastichina Côa Valley Cytotoxicity Glioblastoma |
description |
Lavandula pedunculata (Mill.) Cav., Mentha cervina L. and Thymus mastichina (L.) L. subsp. mastichina are representative species of the Coa Valley's flora, a Portuguese UNESCO World Heritage Site. L. pedunculata and T. mastichina are traditionally used to preserve olives and to aromatize bonfires on Saint John's Eve, while M. cervina is mainly used as a spice for river fish dishes. Despite their traditional uses, these aromatic plants are still undervalued, and literature regarding their bioactivity, especially anticancer, is scarce. In this work, the morphology of secretory structures was assessed by scanning electron microscopy (SEM), and the composition of essential oils (EOs) was characterized by gas chromatography-mass spectrometry (GC-MS). The study proceeded with cytotoxic evaluation of EOs in tumor and non-tumor cells with the cell death mechanism explored in glioblastoma (GB) cells. L. pedunculata EO presented the most pronounced cytotoxic/antiproliferative activity against tumor cells, with moderate cytotoxicity against non-tumor cells. Whereas, M. cervina EO exhibited a slightly lower cytotoxic effect against tumor cells and did not affect the viability of non-tumor cells. Meanwhile, T. mastichina EO did not induce a strong cytotoxic effect against GB cells. L. pedunculata and M. cervina EOs lead to cell death by inducing apoptosis in a dose-dependent manner. The present study suggests that L. pedunculata and M. cervina EOs have a strong cytotoxic and antiproliferative potential to be further studied as efficient antitumor agents. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-02-21T16:27:17Z 2023 2023-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10198/15905 |
url |
http://hdl.handle.net/10198/15905 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Marques, Mário P.; Neves, Beatriz Guapo; Varela, Carla; Zuzarte, Mónica; Goncalves, Ana Cristina; Dias, Maria Inês; Amaral, Joana S.; Barros, Lillian; Magalhães, Mariana; Cabral, Célia (2023). Essential oils from coa valley lamiaceae species: cytotoxicity and antiproliferative effect on glioblastoma cells. Pharmaceutics. eISSN 1999-4923. 15:2, p. 1-18 10.3390/pharmaceutics15020341 1999-4923 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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MDPI |
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MDPI |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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