Essential oils from coa valley lamiaceae species: cytotoxicity and antiproliferative effect on glioblastoma cells

Detalhes bibliográficos
Autor(a) principal: Marques, Mário P.
Data de Publicação: 2018
Outros Autores: Neves, Beatriz Guapo, Varela, Carla, Zuzarte, Mónica, Goncalves, Ana Cristina, Dias, Maria Inês, Amaral, Joana S., Barros, Lillian, Magalhães, Mariana, Cabral, Célia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10198/15905
Resumo: Lavandula pedunculata (Mill.) Cav., Mentha cervina L. and Thymus mastichina (L.) L. subsp. mastichina are representative species of the Coa Valley's flora, a Portuguese UNESCO World Heritage Site. L. pedunculata and T. mastichina are traditionally used to preserve olives and to aromatize bonfires on Saint John's Eve, while M. cervina is mainly used as a spice for river fish dishes. Despite their traditional uses, these aromatic plants are still undervalued, and literature regarding their bioactivity, especially anticancer, is scarce. In this work, the morphology of secretory structures was assessed by scanning electron microscopy (SEM), and the composition of essential oils (EOs) was characterized by gas chromatography-mass spectrometry (GC-MS). The study proceeded with cytotoxic evaluation of EOs in tumor and non-tumor cells with the cell death mechanism explored in glioblastoma (GB) cells. L. pedunculata EO presented the most pronounced cytotoxic/antiproliferative activity against tumor cells, with moderate cytotoxicity against non-tumor cells. Whereas, M. cervina EO exhibited a slightly lower cytotoxic effect against tumor cells and did not affect the viability of non-tumor cells. Meanwhile, T. mastichina EO did not induce a strong cytotoxic effect against GB cells. L. pedunculata and M. cervina EOs lead to cell death by inducing apoptosis in a dose-dependent manner. The present study suggests that L. pedunculata and M. cervina EOs have a strong cytotoxic and antiproliferative potential to be further studied as efficient antitumor agents.
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spelling Essential oils from coa valley lamiaceae species: cytotoxicity and antiproliferative effect on glioblastoma cellsEssential oilsLavandula pedunculataMentha cervinaThymus mastichina subsp. mastichinaCôa ValleyCytotoxicityGlioblastomaLavandula pedunculata (Mill.) Cav., Mentha cervina L. and Thymus mastichina (L.) L. subsp. mastichina are representative species of the Coa Valley's flora, a Portuguese UNESCO World Heritage Site. L. pedunculata and T. mastichina are traditionally used to preserve olives and to aromatize bonfires on Saint John's Eve, while M. cervina is mainly used as a spice for river fish dishes. Despite their traditional uses, these aromatic plants are still undervalued, and literature regarding their bioactivity, especially anticancer, is scarce. In this work, the morphology of secretory structures was assessed by scanning electron microscopy (SEM), and the composition of essential oils (EOs) was characterized by gas chromatography-mass spectrometry (GC-MS). The study proceeded with cytotoxic evaluation of EOs in tumor and non-tumor cells with the cell death mechanism explored in glioblastoma (GB) cells. L. pedunculata EO presented the most pronounced cytotoxic/antiproliferative activity against tumor cells, with moderate cytotoxicity against non-tumor cells. Whereas, M. cervina EO exhibited a slightly lower cytotoxic effect against tumor cells and did not affect the viability of non-tumor cells. Meanwhile, T. mastichina EO did not induce a strong cytotoxic effect against GB cells. L. pedunculata and M. cervina EOs lead to cell death by inducing apoptosis in a dose-dependent manner. The present study suggests that L. pedunculata and M. cervina EOs have a strong cytotoxic and antiproliferative potential to be further studied as efficient antitumor agents.MDPIBiblioteca Digital do IPBMarques, Mário P.Neves, Beatriz GuapoVarela, CarlaZuzarte, MónicaGoncalves, Ana CristinaDias, Maria InêsAmaral, Joana S.Barros, LillianMagalhães, MarianaCabral, Célia2018-02-21T16:27:17Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/15905engMarques, Mário P.; Neves, Beatriz Guapo; Varela, Carla; Zuzarte, Mónica; Goncalves, Ana Cristina; Dias, Maria Inês; Amaral, Joana S.; Barros, Lillian; Magalhães, Mariana; Cabral, Célia (2023). Essential oils from coa valley lamiaceae species: cytotoxicity and antiproliferative effect on glioblastoma cells. Pharmaceutics. eISSN 1999-4923. 15:2, p. 1-1810.3390/pharmaceutics150203411999-4923info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-07T01:18:08Zoai:bibliotecadigital.ipb.pt:10198/15905Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:05:14.102128Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Essential oils from coa valley lamiaceae species: cytotoxicity and antiproliferative effect on glioblastoma cells
title Essential oils from coa valley lamiaceae species: cytotoxicity and antiproliferative effect on glioblastoma cells
spellingShingle Essential oils from coa valley lamiaceae species: cytotoxicity and antiproliferative effect on glioblastoma cells
Marques, Mário P.
Essential oils
Lavandula pedunculata
Mentha cervina
Thymus mastichina subsp. mastichina
Côa Valley
Cytotoxicity
Glioblastoma
title_short Essential oils from coa valley lamiaceae species: cytotoxicity and antiproliferative effect on glioblastoma cells
title_full Essential oils from coa valley lamiaceae species: cytotoxicity and antiproliferative effect on glioblastoma cells
title_fullStr Essential oils from coa valley lamiaceae species: cytotoxicity and antiproliferative effect on glioblastoma cells
title_full_unstemmed Essential oils from coa valley lamiaceae species: cytotoxicity and antiproliferative effect on glioblastoma cells
title_sort Essential oils from coa valley lamiaceae species: cytotoxicity and antiproliferative effect on glioblastoma cells
author Marques, Mário P.
author_facet Marques, Mário P.
Neves, Beatriz Guapo
Varela, Carla
Zuzarte, Mónica
Goncalves, Ana Cristina
Dias, Maria Inês
Amaral, Joana S.
Barros, Lillian
Magalhães, Mariana
Cabral, Célia
author_role author
author2 Neves, Beatriz Guapo
Varela, Carla
Zuzarte, Mónica
Goncalves, Ana Cristina
Dias, Maria Inês
Amaral, Joana S.
Barros, Lillian
Magalhães, Mariana
Cabral, Célia
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Biblioteca Digital do IPB
dc.contributor.author.fl_str_mv Marques, Mário P.
Neves, Beatriz Guapo
Varela, Carla
Zuzarte, Mónica
Goncalves, Ana Cristina
Dias, Maria Inês
Amaral, Joana S.
Barros, Lillian
Magalhães, Mariana
Cabral, Célia
dc.subject.por.fl_str_mv Essential oils
Lavandula pedunculata
Mentha cervina
Thymus mastichina subsp. mastichina
Côa Valley
Cytotoxicity
Glioblastoma
topic Essential oils
Lavandula pedunculata
Mentha cervina
Thymus mastichina subsp. mastichina
Côa Valley
Cytotoxicity
Glioblastoma
description Lavandula pedunculata (Mill.) Cav., Mentha cervina L. and Thymus mastichina (L.) L. subsp. mastichina are representative species of the Coa Valley's flora, a Portuguese UNESCO World Heritage Site. L. pedunculata and T. mastichina are traditionally used to preserve olives and to aromatize bonfires on Saint John's Eve, while M. cervina is mainly used as a spice for river fish dishes. Despite their traditional uses, these aromatic plants are still undervalued, and literature regarding their bioactivity, especially anticancer, is scarce. In this work, the morphology of secretory structures was assessed by scanning electron microscopy (SEM), and the composition of essential oils (EOs) was characterized by gas chromatography-mass spectrometry (GC-MS). The study proceeded with cytotoxic evaluation of EOs in tumor and non-tumor cells with the cell death mechanism explored in glioblastoma (GB) cells. L. pedunculata EO presented the most pronounced cytotoxic/antiproliferative activity against tumor cells, with moderate cytotoxicity against non-tumor cells. Whereas, M. cervina EO exhibited a slightly lower cytotoxic effect against tumor cells and did not affect the viability of non-tumor cells. Meanwhile, T. mastichina EO did not induce a strong cytotoxic effect against GB cells. L. pedunculata and M. cervina EOs lead to cell death by inducing apoptosis in a dose-dependent manner. The present study suggests that L. pedunculata and M. cervina EOs have a strong cytotoxic and antiproliferative potential to be further studied as efficient antitumor agents.
publishDate 2018
dc.date.none.fl_str_mv 2018-02-21T16:27:17Z
2023
2023-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10198/15905
url http://hdl.handle.net/10198/15905
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Marques, Mário P.; Neves, Beatriz Guapo; Varela, Carla; Zuzarte, Mónica; Goncalves, Ana Cristina; Dias, Maria Inês; Amaral, Joana S.; Barros, Lillian; Magalhães, Mariana; Cabral, Célia (2023). Essential oils from coa valley lamiaceae species: cytotoxicity and antiproliferative effect on glioblastoma cells. Pharmaceutics. eISSN 1999-4923. 15:2, p. 1-18
10.3390/pharmaceutics15020341
1999-4923
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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