Effectiveness of statins on haemodialysis patients with concomitant peripheral arterial disease – a narrative review

Detalhes bibliográficos
Autor(a) principal: Nunes, Celso
Data de Publicação: 2024
Outros Autores: Sousa, Juliana, Oliveira, Vânia, Silva, Eduardo, Baldaia, Leonor, Silva, Miguel, Orelhas, Luis, Fonseca, Manuel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.48750/acv.552
Resumo: INTRODUCTION: The use of statins in hemodialysis patients is a topic of ongoing research and debate. Patients with chronic kidney disease on hemodialysis constitute a large proportion of patients treated in the vascular surgery field. Clinical data of the protective statin effect on this group is scarce and conflicting results exist regarding cardiovascular, cerebrovascular and limb outcomes. METHODS: We performed a thorough electronic search of the literature using PubMed and Embase databases to understand the relationship between statin effect and cardiovascular, limb outcomes and cerebrovascular outcomes. A narrative review was constructed, based on the obtained literature. RESULTS: Although the use of statins in hemodialysis patients may provide cardiovascular benefits, the optimal dosage and safety profile of these medications in this population remain uncertain. A carefully evaluation of the risks and benefits of statins should be made based on each patient's specific requirements and circumstances. CONCLUSION: The role of statins for patients with peripheral arterial disease who are on hemodialysis remains unclear. Further analyses should focus on this subgroup of dialysis patients, who are becoming more prevalent on the vascular surgery departments, allowing for an optimized treatment with better patient outcomes.
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spelling Effectiveness of statins on haemodialysis patients with concomitant peripheral arterial disease – a narrative reviewStatinHemodialysisperipheral arterial diseasepatient outcomesINTRODUCTION: The use of statins in hemodialysis patients is a topic of ongoing research and debate. Patients with chronic kidney disease on hemodialysis constitute a large proportion of patients treated in the vascular surgery field. Clinical data of the protective statin effect on this group is scarce and conflicting results exist regarding cardiovascular, cerebrovascular and limb outcomes. METHODS: We performed a thorough electronic search of the literature using PubMed and Embase databases to understand the relationship between statin effect and cardiovascular, limb outcomes and cerebrovascular outcomes. A narrative review was constructed, based on the obtained literature. RESULTS: Although the use of statins in hemodialysis patients may provide cardiovascular benefits, the optimal dosage and safety profile of these medications in this population remain uncertain. A carefully evaluation of the risks and benefits of statins should be made based on each patient's specific requirements and circumstances. CONCLUSION: The role of statins for patients with peripheral arterial disease who are on hemodialysis remains unclear. Further analyses should focus on this subgroup of dialysis patients, who are becoming more prevalent on the vascular surgery departments, allowing for an optimized treatment with better patient outcomes.Sociedade Portuguesa de Angiologia e Cirurgia Vascular2024-03-03info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.48750/acv.552https://doi.org/10.48750/acv.552Angiologia e Cirurgia Vascular; Vol. 19 No. 4 (2023): December; 218-220Angiologia e Cirurgia Vascular; Vol. 19 N.º 4 (2023): Dezembro; 218-2202183-00961646-706Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://acvjournal.com/index.php/acv/article/view/552http://acvjournal.com/index.php/acv/article/view/552/360Copyright (c) 2024 Angiologia e Cirurgia Vascularinfo:eu-repo/semantics/openAccessNunes, CelsoSousa, JulianaOliveira, VâniaSilva, EduardoBaldaia, LeonorSilva, MiguelOrelhas, LuisFonseca, Manuel2024-03-08T10:30:14Zoai:ojs.acvjournal.com:article/552Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:13:56.911456Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Effectiveness of statins on haemodialysis patients with concomitant peripheral arterial disease – a narrative review
title Effectiveness of statins on haemodialysis patients with concomitant peripheral arterial disease – a narrative review
spellingShingle Effectiveness of statins on haemodialysis patients with concomitant peripheral arterial disease – a narrative review
Nunes, Celso
Statin
Hemodialysis
peripheral arterial disease
patient outcomes
title_short Effectiveness of statins on haemodialysis patients with concomitant peripheral arterial disease – a narrative review
title_full Effectiveness of statins on haemodialysis patients with concomitant peripheral arterial disease – a narrative review
title_fullStr Effectiveness of statins on haemodialysis patients with concomitant peripheral arterial disease – a narrative review
title_full_unstemmed Effectiveness of statins on haemodialysis patients with concomitant peripheral arterial disease – a narrative review
title_sort Effectiveness of statins on haemodialysis patients with concomitant peripheral arterial disease – a narrative review
author Nunes, Celso
author_facet Nunes, Celso
Sousa, Juliana
Oliveira, Vânia
Silva, Eduardo
Baldaia, Leonor
Silva, Miguel
Orelhas, Luis
Fonseca, Manuel
author_role author
author2 Sousa, Juliana
Oliveira, Vânia
Silva, Eduardo
Baldaia, Leonor
Silva, Miguel
Orelhas, Luis
Fonseca, Manuel
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Nunes, Celso
Sousa, Juliana
Oliveira, Vânia
Silva, Eduardo
Baldaia, Leonor
Silva, Miguel
Orelhas, Luis
Fonseca, Manuel
dc.subject.por.fl_str_mv Statin
Hemodialysis
peripheral arterial disease
patient outcomes
topic Statin
Hemodialysis
peripheral arterial disease
patient outcomes
description INTRODUCTION: The use of statins in hemodialysis patients is a topic of ongoing research and debate. Patients with chronic kidney disease on hemodialysis constitute a large proportion of patients treated in the vascular surgery field. Clinical data of the protective statin effect on this group is scarce and conflicting results exist regarding cardiovascular, cerebrovascular and limb outcomes. METHODS: We performed a thorough electronic search of the literature using PubMed and Embase databases to understand the relationship between statin effect and cardiovascular, limb outcomes and cerebrovascular outcomes. A narrative review was constructed, based on the obtained literature. RESULTS: Although the use of statins in hemodialysis patients may provide cardiovascular benefits, the optimal dosage and safety profile of these medications in this population remain uncertain. A carefully evaluation of the risks and benefits of statins should be made based on each patient's specific requirements and circumstances. CONCLUSION: The role of statins for patients with peripheral arterial disease who are on hemodialysis remains unclear. Further analyses should focus on this subgroup of dialysis patients, who are becoming more prevalent on the vascular surgery departments, allowing for an optimized treatment with better patient outcomes.
publishDate 2024
dc.date.none.fl_str_mv 2024-03-03
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.48750/acv.552
https://doi.org/10.48750/acv.552
url https://doi.org/10.48750/acv.552
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv http://acvjournal.com/index.php/acv/article/view/552
http://acvjournal.com/index.php/acv/article/view/552/360
dc.rights.driver.fl_str_mv Copyright (c) 2024 Angiologia e Cirurgia Vascular
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2024 Angiologia e Cirurgia Vascular
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Angiologia e Cirurgia Vascular
publisher.none.fl_str_mv Sociedade Portuguesa de Angiologia e Cirurgia Vascular
dc.source.none.fl_str_mv Angiologia e Cirurgia Vascular; Vol. 19 No. 4 (2023): December; 218-220
Angiologia e Cirurgia Vascular; Vol. 19 N.º 4 (2023): Dezembro; 218-220
2183-0096
1646-706X
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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