Acid/Base Properties of β-Blockers and Benzodiazepines in Sodium Dodecyl Sulfate Micelles. A Spectrophotometric and Potentiometric Study

Detalhes bibliográficos
Autor(a) principal: de Castro, Baltazar
Data de Publicação: 1998
Outros Autores: Gameiro, Paula, Guimarães, Carla, Lima, José L.F.C., Reis, Salette
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10284/8257
Resumo: The effect of sodium dodecyl sulfate (SDS) micelles on the acid-base properties of two family of pharmaceutical drugs (beta-blockers and benzodiazepines) at 25 degrees C and I = 0.1 M NaCl have been studied. The characterization of the several solution equilibria for the system drug/SDS micelle solution was performed by potentiometry and spectrophotometry, below and above the critical micelle concentration (cmc). Two widely used models have been applied to quantify the effect of micelles on the pKa of the drugs, and the results obtained point to different interactions of each family of drugs with the micelles.
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spelling Acid/Base Properties of β-Blockers and Benzodiazepines in Sodium Dodecyl Sulfate Micelles. A Spectrophotometric and Potentiometric StudyAdrenergic beta-AntagonistsBenzodiazepinesElectrochemistryHydrogen-Ion ConcentrationMicellesModels, ChemicalSodium Dodecyl SulfateSpectrophotometry, UltravioletThe effect of sodium dodecyl sulfate (SDS) micelles on the acid-base properties of two family of pharmaceutical drugs (beta-blockers and benzodiazepines) at 25 degrees C and I = 0.1 M NaCl have been studied. The characterization of the several solution equilibria for the system drug/SDS micelle solution was performed by potentiometry and spectrophotometry, below and above the critical micelle concentration (cmc). Two widely used models have been applied to quantify the effect of micelles on the pKa of the drugs, and the results obtained point to different interactions of each family of drugs with the micelles.ElsevierRepositório Institucional da Universidade Fernando Pessoade Castro, BaltazarGameiro, PaulaGuimarães, CarlaLima, José L.F.C.Reis, Salette2019-11-27T12:44:56Z1998-01-01T00:00:00Z1998-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10284/8257eng0022-354910.1021/js970219kmetadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-06T02:07:39Zoai:bdigital.ufp.pt:10284/8257Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:45:10.037456Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Acid/Base Properties of β-Blockers and Benzodiazepines in Sodium Dodecyl Sulfate Micelles. A Spectrophotometric and Potentiometric Study
title Acid/Base Properties of β-Blockers and Benzodiazepines in Sodium Dodecyl Sulfate Micelles. A Spectrophotometric and Potentiometric Study
spellingShingle Acid/Base Properties of β-Blockers and Benzodiazepines in Sodium Dodecyl Sulfate Micelles. A Spectrophotometric and Potentiometric Study
de Castro, Baltazar
Adrenergic beta-Antagonists
Benzodiazepines
Electrochemistry
Hydrogen-Ion Concentration
Micelles
Models, Chemical
Sodium Dodecyl Sulfate
Spectrophotometry, Ultraviolet
title_short Acid/Base Properties of β-Blockers and Benzodiazepines in Sodium Dodecyl Sulfate Micelles. A Spectrophotometric and Potentiometric Study
title_full Acid/Base Properties of β-Blockers and Benzodiazepines in Sodium Dodecyl Sulfate Micelles. A Spectrophotometric and Potentiometric Study
title_fullStr Acid/Base Properties of β-Blockers and Benzodiazepines in Sodium Dodecyl Sulfate Micelles. A Spectrophotometric and Potentiometric Study
title_full_unstemmed Acid/Base Properties of β-Blockers and Benzodiazepines in Sodium Dodecyl Sulfate Micelles. A Spectrophotometric and Potentiometric Study
title_sort Acid/Base Properties of β-Blockers and Benzodiazepines in Sodium Dodecyl Sulfate Micelles. A Spectrophotometric and Potentiometric Study
author de Castro, Baltazar
author_facet de Castro, Baltazar
Gameiro, Paula
Guimarães, Carla
Lima, José L.F.C.
Reis, Salette
author_role author
author2 Gameiro, Paula
Guimarães, Carla
Lima, José L.F.C.
Reis, Salette
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório Institucional da Universidade Fernando Pessoa
dc.contributor.author.fl_str_mv de Castro, Baltazar
Gameiro, Paula
Guimarães, Carla
Lima, José L.F.C.
Reis, Salette
dc.subject.por.fl_str_mv Adrenergic beta-Antagonists
Benzodiazepines
Electrochemistry
Hydrogen-Ion Concentration
Micelles
Models, Chemical
Sodium Dodecyl Sulfate
Spectrophotometry, Ultraviolet
topic Adrenergic beta-Antagonists
Benzodiazepines
Electrochemistry
Hydrogen-Ion Concentration
Micelles
Models, Chemical
Sodium Dodecyl Sulfate
Spectrophotometry, Ultraviolet
description The effect of sodium dodecyl sulfate (SDS) micelles on the acid-base properties of two family of pharmaceutical drugs (beta-blockers and benzodiazepines) at 25 degrees C and I = 0.1 M NaCl have been studied. The characterization of the several solution equilibria for the system drug/SDS micelle solution was performed by potentiometry and spectrophotometry, below and above the critical micelle concentration (cmc). Two widely used models have been applied to quantify the effect of micelles on the pKa of the drugs, and the results obtained point to different interactions of each family of drugs with the micelles.
publishDate 1998
dc.date.none.fl_str_mv 1998-01-01T00:00:00Z
1998-01-01T00:00:00Z
2019-11-27T12:44:56Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10284/8257
url http://hdl.handle.net/10284/8257
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0022-3549
10.1021/js970219k
dc.rights.driver.fl_str_mv metadata only access
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eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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