Impairment of episodic memory in genetic frontotemporal dementia : a GENFI study
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/48179 |
Resumo: | © 2021 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
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Impairment of episodic memory in genetic frontotemporal dementia : a GENFI studyCognitionEpisodic memoryExecutive functionFrontal lobeFrontotemporal dementiaGenetic disordersNeuropsychologyTemporal lobeVoxel‐based morphometry© 2021 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.Introduction: We aimed to assess episodic memory in genetic frontotemporal dementia (FTD) with the Free and Cued Selective Reminding Test (FCSRT). Methods: The FCSRT was administered in 417 presymptomatic and symptomatic mutation carriers (181 chromosome 9 open reading frame 72 [C9orf72], 163 progranulin [GRN], and 73 microtubule-associated protein tau [MAPT]) and 290 controls. Group differences and correlations with other neuropsychological tests were examined. We performed voxel-based morphometry to investigate the underlying neural substrates of the FCSRT. Results: All symptomatic mutation carrier groups and presymptomatic MAPT mutation carriers performed significantly worse on all FCSRT scores compared to controls. In the presymptomatic C9orf72 group, deficits were found on all scores except for the delayed total recall task, while no deficits were found in presymptomatic GRN mutation carriers. Performance on the FCSRT correlated with executive function, particularly in C9orf72 mutation carriers, but also with memory and naming tasks in the MAPT group. FCSRT performance also correlated with gray matter volumes of frontal, temporal, and subcortical regions in C9orf72 and GRN, but mainly temporal areas in MAPT mutation carriers. Discussion: The FCSRT detects presymptomatic deficits in C9orf72- and MAPT-associated FTD and provides important insight into the underlying cause of memory impairment in different forms of FTD.The Dementia Research Centre is supported by Alzheimer's Research UK, Alzheimer's Society, Brain Research UK, and The Wolfson Foundation. This work was supported by the NIHR UCL/H Biomedical Research Centre, the Leonard Wolfson Experimental Neurology Centre (LWENC) Clinical Research Facility, and the UK Dementia Research Institute, which receives its funding from UK DRI Ltd, funded by the UK Medical Research Council, Alzheimer's Society, and Alzheimer's Research UK. J. D. Rohrer is supported by an MRC Clinician Scientist Fellowship (MR/M008525/1) and has received funding from the NIHR Rare Disease Translational Research Collaboration (BRC149/NS/MH). This work was also supported by the MRC UK GENFI grant (MR/M023664/1); the Bluefield Project; the JPND GENFI-PROX grant (2019-02248); the Dioraphte Foundation (grant numbers 09-02-00); the Association for Frontotemporal Dementias Research Grant 2009; The Netherlands Organization for Scientific Research (NWO; grant HCMI 056-13-018); ZonMw Memorabel (Deltaplan Dementie, project numbers 733 050 103 and 733 050 813); JPND PreFrontAls consortium (project number 733051042). J. M. Poos is supported by a Fellowship award from Alzheimer Nederland (WE.15-2019.02). This work was conducted using the MRC Dementias Platform UK (MR/L023784/1 and MR/009076/1). Several authors of this publication are members of the European Reference Network for Rare Neurological Diseases - Project ID No 739510.John Wiley & Sons, Inc.Repositório da Universidade de LisboaPoos, Jackie M.Russell, Lucy L.Peakman, GeorgiaBocchetta, MartinaGreaves, Caroline V.Jiskoot, Lize C.Ende, Emma L.Seelaar, HarroPapma, Janne M.den Berg, EstherPijnenburg, Yolande A.L.Bruffaerts, RoseVandamme, PhilipVandenbulcke, MathieuFerreira, Catarina B.Miltenberger-Miltenyi, GabrielMaruta, CarolinaVerdelho, AnaAfonso, SóniaTaipa, RicardoCaroppo, PaolaBorroni, BarbaraDi Fede, GiuseppeGiaccone, GiorgioPrioni, SaraRedaelli, VeronicaRossi, GiacominaTiraboschi, PietroDuro, DianaAlmeida, Maria RosarioCastelo‐Branco, MiguelLeitão, Maria JoãoSanchez‐Valle, RaquelTabuas‐Pereira, MiguelSantiago, BeatrizGauthier, SergeRosa‐Neto, PedroVeldsman, MicheleThompson, PaulLangheinrich, TobiasPrix, CatharinaHoegen, TobiasWlasich, ElisabethMoreno, FerminLoosli, SandraSchonecker, SonjaAnderl‐Straub, SarahLombardi, JolinaBargalló, NuriaBenussi, AlbertoCantoni, ValentinaBertoux, MaximeBertrand, AnneBrice, AlexisLaforce, RobertCamuzat, AgnèsColliot, OlivierSayah, SabrinaFunkiewiez, AurélieRinaldi, DaisyLombardi, GemmaNacmias, BenedettaSaracino, DarioBessi, ValentinaFerrari, CamillaGraff, CarolineCañada, MartaDeramecourt, VincentKuchcinski, GregoryLebouvier, ThibaudOurselin, SebastienPolito, CristinaRollin, AdelineSynofzik, MatthiasGalimberti, DanielaRowe, James B.Masellis, MarioTartaglia, CarmelaFinger, ElizabethVandenberghe, RikMedonça, AlexandreTagliavini, FabrizioButler, Chris R.Santana, IsabelBer, Isabelle LeGerhard, AlexDucharme, SimonLevin, JohannesDanek, AdrianOtto, MarkusSorbi, SandroPasquier, FlorenceSwieten, John C.Rohrer, Jonathan D.Rossor, Martin N.Fox, Nick C.Warren, Jason D.Moore, KatrinaConvery, RhianSwift, Imogen J.Shafei, RachelleHeller, CarolinTodd, EmilyBouzigues, ArabellaCash, DavidWoollacott, IoneZetterberg, HenrikNelson, AnnabelNicholas, JenniferGuerreiro, RitaBras, JoseThomas, David L.Mead, SimonMeeter, LiekePanman, JessicaMinkelen, RickBarandiaran, MyriamIndakoetxea, BegoñaGabilondo, AlazneTainta, MikelGorostidi, AnaZulaica, MirenDíez, AlinaVillanua, JorgeBorrego‐Ecija, SergiJaume, OlivesLladó, AlbertBalasa, MirceaAntonell, AnnaBargallo, NuriaPremi, EnricoGazzina, StefanoGasparotti, RobertoArchetti, SilvanaBlack, SandraMitchell, SaraRogaeva, EkaterinaFreedman, MorrisKeren, RonTang‐Wai, DavidThonberg, HakanÖijerstedt, LinnAndersson, ChristinJelic, VesnaArighi, AndreaFenoglio, ChiaraScarpini, ElioFumagalli, GiorgioCope, ThomasTimberlake, CarolynRittman, TimothyShoesmith, ChristenBartha, RobartRademakers, RosaWilke, CarloKarnarth, Hans‐OttoBender, Benjamin2021-05-26T11:24:35Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/48179engAlzheimers Dement (Amst). 2021 May 13;13(1):e1218510.1002/dad2.121852352-8729info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-20T18:06:54Zoai:repositorio.ul.pt:10451/48179Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-20T18:06:54Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Impairment of episodic memory in genetic frontotemporal dementia : a GENFI study |
title |
Impairment of episodic memory in genetic frontotemporal dementia : a GENFI study |
spellingShingle |
Impairment of episodic memory in genetic frontotemporal dementia : a GENFI study Poos, Jackie M. Cognition Episodic memory Executive function Frontal lobe Frontotemporal dementia Genetic disorders Neuropsychology Temporal lobe Voxel‐based morphometry |
title_short |
Impairment of episodic memory in genetic frontotemporal dementia : a GENFI study |
title_full |
Impairment of episodic memory in genetic frontotemporal dementia : a GENFI study |
title_fullStr |
Impairment of episodic memory in genetic frontotemporal dementia : a GENFI study |
title_full_unstemmed |
Impairment of episodic memory in genetic frontotemporal dementia : a GENFI study |
title_sort |
Impairment of episodic memory in genetic frontotemporal dementia : a GENFI study |
author |
Poos, Jackie M. |
author_facet |
Poos, Jackie M. Russell, Lucy L. Peakman, Georgia Bocchetta, Martina Greaves, Caroline V. Jiskoot, Lize C. Ende, Emma L. Seelaar, Harro Papma, Janne M. den Berg, Esther Pijnenburg, Yolande A.L. Bruffaerts, Rose Vandamme, Philip Vandenbulcke, Mathieu Ferreira, Catarina B. Miltenberger-Miltenyi, Gabriel Maruta, Carolina Verdelho, Ana Afonso, Sónia Taipa, Ricardo Caroppo, Paola Borroni, Barbara Di Fede, Giuseppe Giaccone, Giorgio Prioni, Sara Redaelli, Veronica Rossi, Giacomina Tiraboschi, Pietro Duro, Diana Almeida, Maria Rosario Castelo‐Branco, Miguel Leitão, Maria João Sanchez‐Valle, Raquel Tabuas‐Pereira, Miguel Santiago, Beatriz Gauthier, Serge Rosa‐Neto, Pedro Veldsman, Michele Thompson, Paul Langheinrich, Tobias Prix, Catharina Hoegen, Tobias Wlasich, Elisabeth Moreno, Fermin Loosli, Sandra Schonecker, Sonja Anderl‐Straub, Sarah Lombardi, Jolina Bargalló, Nuria Benussi, Alberto Cantoni, Valentina Bertoux, Maxime Bertrand, Anne Brice, Alexis Laforce, Robert Camuzat, Agnès Colliot, Olivier Sayah, Sabrina Funkiewiez, Aurélie Rinaldi, Daisy Lombardi, Gemma Nacmias, Benedetta Saracino, Dario Bessi, Valentina Ferrari, Camilla Graff, Caroline Cañada, Marta Deramecourt, Vincent Kuchcinski, Gregory Lebouvier, Thibaud Ourselin, Sebastien Polito, Cristina Rollin, Adeline Synofzik, Matthias Galimberti, Daniela Rowe, James B. Masellis, Mario Tartaglia, Carmela Finger, Elizabeth Vandenberghe, Rik Medonça, Alexandre Tagliavini, Fabrizio Butler, Chris R. Santana, Isabel Ber, Isabelle Le Gerhard, Alex Ducharme, Simon Levin, Johannes Danek, Adrian Otto, Markus Sorbi, Sandro Pasquier, Florence Swieten, John C. Rohrer, Jonathan D. Rossor, Martin N. Fox, Nick C. Warren, Jason D. Moore, Katrina Convery, Rhian Swift, Imogen J. Shafei, Rachelle Heller, Carolin Todd, Emily Bouzigues, Arabella Cash, David Woollacott, Ione Zetterberg, Henrik Nelson, Annabel Nicholas, Jennifer Guerreiro, Rita Bras, Jose Thomas, David L. Mead, Simon Meeter, Lieke Panman, Jessica Minkelen, Rick Barandiaran, Myriam Indakoetxea, Begoña Gabilondo, Alazne Tainta, Mikel Gorostidi, Ana Zulaica, Miren Díez, Alina Villanua, Jorge Borrego‐Ecija, Sergi Jaume, Olives Lladó, Albert Balasa, Mircea Antonell, Anna Bargallo, Nuria Premi, Enrico Gazzina, Stefano Gasparotti, Roberto Archetti, Silvana Black, Sandra Mitchell, Sara Rogaeva, Ekaterina Freedman, Morris Keren, Ron Tang‐Wai, David Thonberg, Hakan Öijerstedt, Linn Andersson, Christin Jelic, Vesna Arighi, Andrea Fenoglio, Chiara Scarpini, Elio Fumagalli, Giorgio Cope, Thomas Timberlake, Carolyn Rittman, Timothy Shoesmith, Christen Bartha, Robart Rademakers, Rosa Wilke, Carlo Karnarth, Hans‐Otto Bender, Benjamin |
author_role |
author |
author2 |
Russell, Lucy L. Peakman, Georgia Bocchetta, Martina Greaves, Caroline V. Jiskoot, Lize C. Ende, Emma L. Seelaar, Harro Papma, Janne M. den Berg, Esther Pijnenburg, Yolande A.L. Bruffaerts, Rose Vandamme, Philip Vandenbulcke, Mathieu Ferreira, Catarina B. Miltenberger-Miltenyi, Gabriel Maruta, Carolina Verdelho, Ana Afonso, Sónia Taipa, Ricardo Caroppo, Paola Borroni, Barbara Di Fede, Giuseppe Giaccone, Giorgio Prioni, Sara Redaelli, Veronica Rossi, Giacomina Tiraboschi, Pietro Duro, Diana Almeida, Maria Rosario Castelo‐Branco, Miguel Leitão, Maria João Sanchez‐Valle, Raquel Tabuas‐Pereira, Miguel Santiago, Beatriz Gauthier, Serge Rosa‐Neto, Pedro Veldsman, Michele Thompson, Paul Langheinrich, Tobias Prix, Catharina Hoegen, Tobias Wlasich, Elisabeth Moreno, Fermin Loosli, Sandra Schonecker, Sonja Anderl‐Straub, Sarah Lombardi, Jolina Bargalló, Nuria Benussi, Alberto Cantoni, Valentina Bertoux, Maxime Bertrand, Anne Brice, Alexis Laforce, Robert Camuzat, Agnès Colliot, Olivier Sayah, Sabrina Funkiewiez, Aurélie Rinaldi, Daisy Lombardi, Gemma Nacmias, Benedetta Saracino, Dario Bessi, Valentina Ferrari, Camilla Graff, Caroline Cañada, Marta Deramecourt, Vincent Kuchcinski, Gregory Lebouvier, Thibaud Ourselin, Sebastien Polito, Cristina Rollin, Adeline Synofzik, Matthias Galimberti, Daniela Rowe, James B. Masellis, Mario Tartaglia, Carmela Finger, Elizabeth Vandenberghe, Rik Medonça, Alexandre Tagliavini, Fabrizio Butler, Chris R. Santana, Isabel Ber, Isabelle Le Gerhard, Alex Ducharme, Simon Levin, Johannes Danek, Adrian Otto, Markus Sorbi, Sandro Pasquier, Florence Swieten, John C. Rohrer, Jonathan D. Rossor, Martin N. Fox, Nick C. Warren, Jason D. Moore, Katrina Convery, Rhian Swift, Imogen J. Shafei, Rachelle Heller, Carolin Todd, Emily Bouzigues, Arabella Cash, David Woollacott, Ione Zetterberg, Henrik Nelson, Annabel Nicholas, Jennifer Guerreiro, Rita Bras, Jose Thomas, David L. Mead, Simon Meeter, Lieke Panman, Jessica Minkelen, Rick Barandiaran, Myriam Indakoetxea, Begoña Gabilondo, Alazne Tainta, Mikel Gorostidi, Ana Zulaica, Miren Díez, Alina Villanua, Jorge Borrego‐Ecija, Sergi Jaume, Olives Lladó, Albert Balasa, Mircea Antonell, Anna Bargallo, Nuria Premi, Enrico Gazzina, Stefano Gasparotti, Roberto Archetti, Silvana Black, Sandra Mitchell, Sara Rogaeva, Ekaterina Freedman, Morris Keren, Ron Tang‐Wai, David Thonberg, Hakan Öijerstedt, Linn Andersson, Christin Jelic, Vesna Arighi, Andrea Fenoglio, Chiara Scarpini, Elio Fumagalli, Giorgio Cope, Thomas Timberlake, Carolyn Rittman, Timothy Shoesmith, Christen Bartha, Robart Rademakers, Rosa Wilke, Carlo Karnarth, Hans‐Otto Bender, Benjamin |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Poos, Jackie M. Russell, Lucy L. Peakman, Georgia Bocchetta, Martina Greaves, Caroline V. Jiskoot, Lize C. Ende, Emma L. Seelaar, Harro Papma, Janne M. den Berg, Esther Pijnenburg, Yolande A.L. Bruffaerts, Rose Vandamme, Philip Vandenbulcke, Mathieu Ferreira, Catarina B. Miltenberger-Miltenyi, Gabriel Maruta, Carolina Verdelho, Ana Afonso, Sónia Taipa, Ricardo Caroppo, Paola Borroni, Barbara Di Fede, Giuseppe Giaccone, Giorgio Prioni, Sara Redaelli, Veronica Rossi, Giacomina Tiraboschi, Pietro Duro, Diana Almeida, Maria Rosario Castelo‐Branco, Miguel Leitão, Maria João Sanchez‐Valle, Raquel Tabuas‐Pereira, Miguel Santiago, Beatriz Gauthier, Serge Rosa‐Neto, Pedro Veldsman, Michele Thompson, Paul Langheinrich, Tobias Prix, Catharina Hoegen, Tobias Wlasich, Elisabeth Moreno, Fermin Loosli, Sandra Schonecker, Sonja Anderl‐Straub, Sarah Lombardi, Jolina Bargalló, Nuria Benussi, Alberto Cantoni, Valentina Bertoux, Maxime Bertrand, Anne Brice, Alexis Laforce, Robert Camuzat, Agnès Colliot, Olivier Sayah, Sabrina Funkiewiez, Aurélie Rinaldi, Daisy Lombardi, Gemma Nacmias, Benedetta Saracino, Dario Bessi, Valentina Ferrari, Camilla Graff, Caroline Cañada, Marta Deramecourt, Vincent Kuchcinski, Gregory Lebouvier, Thibaud Ourselin, Sebastien Polito, Cristina Rollin, Adeline Synofzik, Matthias Galimberti, Daniela Rowe, James B. Masellis, Mario Tartaglia, Carmela Finger, Elizabeth Vandenberghe, Rik Medonça, Alexandre Tagliavini, Fabrizio Butler, Chris R. Santana, Isabel Ber, Isabelle Le Gerhard, Alex Ducharme, Simon Levin, Johannes Danek, Adrian Otto, Markus Sorbi, Sandro Pasquier, Florence Swieten, John C. Rohrer, Jonathan D. Rossor, Martin N. Fox, Nick C. Warren, Jason D. Moore, Katrina Convery, Rhian Swift, Imogen J. Shafei, Rachelle Heller, Carolin Todd, Emily Bouzigues, Arabella Cash, David Woollacott, Ione Zetterberg, Henrik Nelson, Annabel Nicholas, Jennifer Guerreiro, Rita Bras, Jose Thomas, David L. Mead, Simon Meeter, Lieke Panman, Jessica Minkelen, Rick Barandiaran, Myriam Indakoetxea, Begoña Gabilondo, Alazne Tainta, Mikel Gorostidi, Ana Zulaica, Miren Díez, Alina Villanua, Jorge Borrego‐Ecija, Sergi Jaume, Olives Lladó, Albert Balasa, Mircea Antonell, Anna Bargallo, Nuria Premi, Enrico Gazzina, Stefano Gasparotti, Roberto Archetti, Silvana Black, Sandra Mitchell, Sara Rogaeva, Ekaterina Freedman, Morris Keren, Ron Tang‐Wai, David Thonberg, Hakan Öijerstedt, Linn Andersson, Christin Jelic, Vesna Arighi, Andrea Fenoglio, Chiara Scarpini, Elio Fumagalli, Giorgio Cope, Thomas Timberlake, Carolyn Rittman, Timothy Shoesmith, Christen Bartha, Robart Rademakers, Rosa Wilke, Carlo Karnarth, Hans‐Otto Bender, Benjamin |
dc.subject.por.fl_str_mv |
Cognition Episodic memory Executive function Frontal lobe Frontotemporal dementia Genetic disorders Neuropsychology Temporal lobe Voxel‐based morphometry |
topic |
Cognition Episodic memory Executive function Frontal lobe Frontotemporal dementia Genetic disorders Neuropsychology Temporal lobe Voxel‐based morphometry |
description |
© 2021 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-05-26T11:24:35Z 2021 2021-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/48179 |
url |
http://hdl.handle.net/10451/48179 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Alzheimers Dement (Amst). 2021 May 13;13(1):e12185 10.1002/dad2.12185 2352-8729 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
John Wiley & Sons, Inc. |
publisher.none.fl_str_mv |
John Wiley & Sons, Inc. |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
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1817549140649836544 |