Nucleoside inhibitors of Zika virus

• Autor(a) principal: Eyer, L.
• Data de Publicação: 2016
• Outros Autores: Nencka, R., Huvarová, I., Palus, M., Alves, M.J., Gould, E.A., De Clercq, E., Rusek, D.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10400.18/4303
• topic: Zika Virus; Flavivirus; Nucleoside Analogue; Antiviral; Therapy; Infecções Sistémicas e Zoonoses

There is growing evidence that Zika virus (ZIKV) can cause devastating infant brain defects and other neurological disorders in humans. However, no specific antiviral therapy is available at present. We tested a series of 2'-C- or 2'-O-methyl-substituted nucleosides, 2'-C-fluoro-2'-C-methyl-substituted nucleosides, 3'-O-methyl-substituted nucleosides, 3'-deoxynucleosides, derivatives with 4'-C-azido substitution, heterobase-modified nucleosides, and neplanocins for their ability to inhibit ZIKV replication in cell culture. Antiviral activity was identified when 2'-C-methylated nucleosides were tested, suggesting that these compounds might represent promising lead candidates for further development of specific antivirals against ZIKV.