Psychotropic drugs and liver disease : a critical review of pharmacokinetics and liver toxicity
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/45820 |
Resumo: | © 2017 Baishideng Publishing Group Inc. All rights reserved. This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license. |
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7160 |
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Psychotropic drugs and liver disease : a critical review of pharmacokinetics and liver toxicityLiverToxicityPsychotropic drugsPharmacokineticsHepatic disease© 2017 Baishideng Publishing Group Inc. All rights reserved. This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license.The liver is the organ by which the majority of substances are metabolized, including psychotropic drugs. There are several pharmacokinetic changes in end-stage liver disease that can interfere with the metabolization of psychotropic drugs. This fact is particularly true in drugs with extensive first-pass metabolism, highly protein bound drugs and drugs depending on phase I hepatic metabolic reactions. Psychopharmacological agents are also associated with a risk of hepatotoxicity. The evidence is insufficient for definite conclusions regarding the prevalence and severity of psychiatric drug-induced liver injury. High-risk psychotropics are not advised when there is pre-existing liver disease, and after starting a psychotropic agent in a patient with hepatic impairment, frequent liver function/lesion monitoring is advised. The authors carefully review the pharmacokinetic disturbances induced by end-stage liver disease and the potential of psychopharmacological agents for liver toxicity.Baishideng Publishing Group Inc.Repositório da Universidade de LisboaTelles-Correia, DiogoBarbosa, AntónioCortez-Pinto, HelenaCampos, CarlosRocha, Nuno B FMachado, Sérgio2021-01-18T17:23:02Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/45820engWorld J Gastrointest Pharmacol Ther. 2017 Feb 6;8(1):26-3810.4292/wjgpt.v8.i1.262150-5349info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:47:49Zoai:repositorio.ul.pt:10451/45820Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:58:08.820651Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Psychotropic drugs and liver disease : a critical review of pharmacokinetics and liver toxicity |
title |
Psychotropic drugs and liver disease : a critical review of pharmacokinetics and liver toxicity |
spellingShingle |
Psychotropic drugs and liver disease : a critical review of pharmacokinetics and liver toxicity Telles-Correia, Diogo Liver Toxicity Psychotropic drugs Pharmacokinetics Hepatic disease |
title_short |
Psychotropic drugs and liver disease : a critical review of pharmacokinetics and liver toxicity |
title_full |
Psychotropic drugs and liver disease : a critical review of pharmacokinetics and liver toxicity |
title_fullStr |
Psychotropic drugs and liver disease : a critical review of pharmacokinetics and liver toxicity |
title_full_unstemmed |
Psychotropic drugs and liver disease : a critical review of pharmacokinetics and liver toxicity |
title_sort |
Psychotropic drugs and liver disease : a critical review of pharmacokinetics and liver toxicity |
author |
Telles-Correia, Diogo |
author_facet |
Telles-Correia, Diogo Barbosa, António Cortez-Pinto, Helena Campos, Carlos Rocha, Nuno B F Machado, Sérgio |
author_role |
author |
author2 |
Barbosa, António Cortez-Pinto, Helena Campos, Carlos Rocha, Nuno B F Machado, Sérgio |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Telles-Correia, Diogo Barbosa, António Cortez-Pinto, Helena Campos, Carlos Rocha, Nuno B F Machado, Sérgio |
dc.subject.por.fl_str_mv |
Liver Toxicity Psychotropic drugs Pharmacokinetics Hepatic disease |
topic |
Liver Toxicity Psychotropic drugs Pharmacokinetics Hepatic disease |
description |
© 2017 Baishideng Publishing Group Inc. All rights reserved. This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 2017-01-01T00:00:00Z 2021-01-18T17:23:02Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/45820 |
url |
http://hdl.handle.net/10451/45820 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
World J Gastrointest Pharmacol Ther. 2017 Feb 6;8(1):26-38 10.4292/wjgpt.v8.i1.26 2150-5349 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Baishideng Publishing Group Inc. |
publisher.none.fl_str_mv |
Baishideng Publishing Group Inc. |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799134526654382080 |