Construction of a quality index for granules produced by fluidized bed technology and application of the correspondence analysis as a discriminant procedure

Detalhes bibliográficos
Autor(a) principal: Albuquerque, M.T.D.
Data de Publicação: 2010
Outros Autores: Dias, H.V., Poellinger, N., Pinto F.J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.11/1470
Resumo: The production of granules by wet granulation in a fluidized bed was assessed after the construction of a quality index based on a file of attributes (relevant factors). These attributes are combined by a methodology relying on Correspondence Analysis, as a discriminant procedure, using two extreme simulated active vectors representing, respectively, the best and the worst cases for the granules quality output (“bad” and “good” pole). From those, a single continuous synthetic variable – the quality index – can be produced referring to a more significant set of samples. As an application of the methodology, the work compares the quality of granules produced at a laboratory scale and a pilot scale. The factors contribution to the bad or good pole allowed the identification of the most relevant factors that affect the quality of the granules. The factors studied, according to a center of gravity design, included formulation (solubility of a drug, different grades of polyvinylpyrrolidone, the polarity of the granulation solution) and processing factors (the rate of administration of the granulation solution, the atomizing air pressure and the fluidizing air rate). Granules were evaluated for production yield, drug content, size, densities (true, bulk and tapped), friability, flowability and compressibility. The study has emphasized the differences between the laboratory and pilot scales and the relative importance of each factor for the quality of the granules produced.
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spelling Construction of a quality index for granules produced by fluidized bed technology and application of the correspondence analysis as a discriminant procedureCorrespondence analysisFluidized bedGranulationQuality indexRelevant factorsThe production of granules by wet granulation in a fluidized bed was assessed after the construction of a quality index based on a file of attributes (relevant factors). These attributes are combined by a methodology relying on Correspondence Analysis, as a discriminant procedure, using two extreme simulated active vectors representing, respectively, the best and the worst cases for the granules quality output (“bad” and “good” pole). From those, a single continuous synthetic variable – the quality index – can be produced referring to a more significant set of samples. As an application of the methodology, the work compares the quality of granules produced at a laboratory scale and a pilot scale. The factors contribution to the bad or good pole allowed the identification of the most relevant factors that affect the quality of the granules. The factors studied, according to a center of gravity design, included formulation (solubility of a drug, different grades of polyvinylpyrrolidone, the polarity of the granulation solution) and processing factors (the rate of administration of the granulation solution, the atomizing air pressure and the fluidizing air rate). Granules were evaluated for production yield, drug content, size, densities (true, bulk and tapped), friability, flowability and compressibility. The study has emphasized the differences between the laboratory and pilot scales and the relative importance of each factor for the quality of the granules produced.ElsevierRepositório Científico do Instituto Politécnico de Castelo BrancoAlbuquerque, M.T.D.Dias, H.V.Poellinger, N.Pinto F.J.2012-10-23T17:01:30Z20102010-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.11/1470engALBUQUERQUE, M.T.D. [et al.] (2010) - Construction of a quality index for granules produced by fluidized bed technology and application of the correspondence analysis as a discriminant procedure. European Journal of Pharmaceutics and Biopharmaceutics. ISSN 0939-6411. Vol. 75, nº 3, p. 418-4240939-6411info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-04-22T01:46:32Zoai:repositorio.ipcb.pt:10400.11/1470Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:32:54.829652Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Construction of a quality index for granules produced by fluidized bed technology and application of the correspondence analysis as a discriminant procedure
title Construction of a quality index for granules produced by fluidized bed technology and application of the correspondence analysis as a discriminant procedure
spellingShingle Construction of a quality index for granules produced by fluidized bed technology and application of the correspondence analysis as a discriminant procedure
Albuquerque, M.T.D.
Correspondence analysis
Fluidized bed
Granulation
Quality index
Relevant factors
title_short Construction of a quality index for granules produced by fluidized bed technology and application of the correspondence analysis as a discriminant procedure
title_full Construction of a quality index for granules produced by fluidized bed technology and application of the correspondence analysis as a discriminant procedure
title_fullStr Construction of a quality index for granules produced by fluidized bed technology and application of the correspondence analysis as a discriminant procedure
title_full_unstemmed Construction of a quality index for granules produced by fluidized bed technology and application of the correspondence analysis as a discriminant procedure
title_sort Construction of a quality index for granules produced by fluidized bed technology and application of the correspondence analysis as a discriminant procedure
author Albuquerque, M.T.D.
author_facet Albuquerque, M.T.D.
Dias, H.V.
Poellinger, N.
Pinto F.J.
author_role author
author2 Dias, H.V.
Poellinger, N.
Pinto F.J.
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico de Castelo Branco
dc.contributor.author.fl_str_mv Albuquerque, M.T.D.
Dias, H.V.
Poellinger, N.
Pinto F.J.
dc.subject.por.fl_str_mv Correspondence analysis
Fluidized bed
Granulation
Quality index
Relevant factors
topic Correspondence analysis
Fluidized bed
Granulation
Quality index
Relevant factors
description The production of granules by wet granulation in a fluidized bed was assessed after the construction of a quality index based on a file of attributes (relevant factors). These attributes are combined by a methodology relying on Correspondence Analysis, as a discriminant procedure, using two extreme simulated active vectors representing, respectively, the best and the worst cases for the granules quality output (“bad” and “good” pole). From those, a single continuous synthetic variable – the quality index – can be produced referring to a more significant set of samples. As an application of the methodology, the work compares the quality of granules produced at a laboratory scale and a pilot scale. The factors contribution to the bad or good pole allowed the identification of the most relevant factors that affect the quality of the granules. The factors studied, according to a center of gravity design, included formulation (solubility of a drug, different grades of polyvinylpyrrolidone, the polarity of the granulation solution) and processing factors (the rate of administration of the granulation solution, the atomizing air pressure and the fluidizing air rate). Granules were evaluated for production yield, drug content, size, densities (true, bulk and tapped), friability, flowability and compressibility. The study has emphasized the differences between the laboratory and pilot scales and the relative importance of each factor for the quality of the granules produced.
publishDate 2010
dc.date.none.fl_str_mv 2010
2010-01-01T00:00:00Z
2012-10-23T17:01:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.11/1470
url http://hdl.handle.net/10400.11/1470
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv ALBUQUERQUE, M.T.D. [et al.] (2010) - Construction of a quality index for granules produced by fluidized bed technology and application of the correspondence analysis as a discriminant procedure. European Journal of Pharmaceutics and Biopharmaceutics. ISSN 0939-6411. Vol. 75, nº 3, p. 418-424
0939-6411
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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