High-Risk human papillomavirus genotype distribution in the Northern region of Portugal: data from regional cervical cancer screening program
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/1822/62312 |
Resumo: | High-Risk Human papillomavirus (HR-HPV) full genotyping methods have been described as of great potential use in epidemiology and preventive strategies, including cervical cancer screening and HPV vaccination. We characterized the prevalence and distribution of HR-HPV genotypes in cervico-vaginal samples obtained from the Regional Cervical Cancer Screening Program from the Northern Region of Portugal. HR-HPV genotyping was performed using Anyplex™ II HPV-HR Detection kit in 105,458 women enrolled between August 2016 and December 2017. HR-HPVs were detected in 10,665 women (10.2%) with a prevalence ranging from 6.2 to 17.1% depending on age, and from 8.7 to 10.7% depending on geographical location. Multiple infections with two or more HR-HPVs were detected in 2736 (25.7%) of HR-HPV women ranging from 16.5 to 31.0% depending on age. Amongst HR-HPV positive women, HPV-16 (17.5%), HPV-39 (16.7%), HPV-31 (15.0%), HPV-68 (13.2%), HPV-52 (10.7%) and HPV-51 (10.6%) were the most common genotypes in our population, being HPV-16 more frequent in women aged from 30 to 45 years and HPV-39 in 50-65 years. Results also show that HPV16/18 are present in 22.1% and HPV16/18/31/33/45/52/58 in 47.6% of HR-HPV positive women. This is the largest study on HR-HPV genotyping for Cervical Cancer Screening in European populations and provides critical data for program management and vaccine policy. |
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High-Risk human papillomavirus genotype distribution in the Northern region of Portugal: data from regional cervical cancer screening programHuman papillomavirus (HPV)Cervical cancerScreeningGenotypingPrevalenceEpidemiologyScience & TechnologyHigh-Risk Human papillomavirus (HR-HPV) full genotyping methods have been described as of great potential use in epidemiology and preventive strategies, including cervical cancer screening and HPV vaccination. We characterized the prevalence and distribution of HR-HPV genotypes in cervico-vaginal samples obtained from the Regional Cervical Cancer Screening Program from the Northern Region of Portugal. HR-HPV genotyping was performed using Anyplex™ II HPV-HR Detection kit in 105,458 women enrolled between August 2016 and December 2017. HR-HPVs were detected in 10,665 women (10.2%) with a prevalence ranging from 6.2 to 17.1% depending on age, and from 8.7 to 10.7% depending on geographical location. Multiple infections with two or more HR-HPVs were detected in 2736 (25.7%) of HR-HPV women ranging from 16.5 to 31.0% depending on age. Amongst HR-HPV positive women, HPV-16 (17.5%), HPV-39 (16.7%), HPV-31 (15.0%), HPV-68 (13.2%), HPV-52 (10.7%) and HPV-51 (10.6%) were the most common genotypes in our population, being HPV-16 more frequent in women aged from 30 to 45 years and HPV-39 in 50-65 years. Results also show that HPV16/18 are present in 22.1% and HPV16/18/31/33/45/52/58 in 47.6% of HR-HPV positive women. This is the largest study on HR-HPV genotyping for Cervical Cancer Screening in European populations and provides critical data for program management and vaccine policy.(undefined)ElsevierUniversidade do MinhoSousa, HugoTavares, AnaCampos, CarlaMarinho-Dias, JoanaBrito, MargaridaMedeiros, RuiBaldaque, InêsLobo, CláudiaLeça, LuísMonteiro, PaulaTavares, FernandoHenrique, Rui2019-082019-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/62312eng2405-85212405-852110.1016/j.pvr.2019.10017931377173info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:12:18Zoai:repositorium.sdum.uminho.pt:1822/62312Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:04:12.626419Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
High-Risk human papillomavirus genotype distribution in the Northern region of Portugal: data from regional cervical cancer screening program |
title |
High-Risk human papillomavirus genotype distribution in the Northern region of Portugal: data from regional cervical cancer screening program |
spellingShingle |
High-Risk human papillomavirus genotype distribution in the Northern region of Portugal: data from regional cervical cancer screening program Sousa, Hugo Human papillomavirus (HPV) Cervical cancer Screening Genotyping Prevalence Epidemiology Science & Technology |
title_short |
High-Risk human papillomavirus genotype distribution in the Northern region of Portugal: data from regional cervical cancer screening program |
title_full |
High-Risk human papillomavirus genotype distribution in the Northern region of Portugal: data from regional cervical cancer screening program |
title_fullStr |
High-Risk human papillomavirus genotype distribution in the Northern region of Portugal: data from regional cervical cancer screening program |
title_full_unstemmed |
High-Risk human papillomavirus genotype distribution in the Northern region of Portugal: data from regional cervical cancer screening program |
title_sort |
High-Risk human papillomavirus genotype distribution in the Northern region of Portugal: data from regional cervical cancer screening program |
author |
Sousa, Hugo |
author_facet |
Sousa, Hugo Tavares, Ana Campos, Carla Marinho-Dias, Joana Brito, Margarida Medeiros, Rui Baldaque, Inês Lobo, Cláudia Leça, Luís Monteiro, Paula Tavares, Fernando Henrique, Rui |
author_role |
author |
author2 |
Tavares, Ana Campos, Carla Marinho-Dias, Joana Brito, Margarida Medeiros, Rui Baldaque, Inês Lobo, Cláudia Leça, Luís Monteiro, Paula Tavares, Fernando Henrique, Rui |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Sousa, Hugo Tavares, Ana Campos, Carla Marinho-Dias, Joana Brito, Margarida Medeiros, Rui Baldaque, Inês Lobo, Cláudia Leça, Luís Monteiro, Paula Tavares, Fernando Henrique, Rui |
dc.subject.por.fl_str_mv |
Human papillomavirus (HPV) Cervical cancer Screening Genotyping Prevalence Epidemiology Science & Technology |
topic |
Human papillomavirus (HPV) Cervical cancer Screening Genotyping Prevalence Epidemiology Science & Technology |
description |
High-Risk Human papillomavirus (HR-HPV) full genotyping methods have been described as of great potential use in epidemiology and preventive strategies, including cervical cancer screening and HPV vaccination. We characterized the prevalence and distribution of HR-HPV genotypes in cervico-vaginal samples obtained from the Regional Cervical Cancer Screening Program from the Northern Region of Portugal. HR-HPV genotyping was performed using Anyplex™ II HPV-HR Detection kit in 105,458 women enrolled between August 2016 and December 2017. HR-HPVs were detected in 10,665 women (10.2%) with a prevalence ranging from 6.2 to 17.1% depending on age, and from 8.7 to 10.7% depending on geographical location. Multiple infections with two or more HR-HPVs were detected in 2736 (25.7%) of HR-HPV women ranging from 16.5 to 31.0% depending on age. Amongst HR-HPV positive women, HPV-16 (17.5%), HPV-39 (16.7%), HPV-31 (15.0%), HPV-68 (13.2%), HPV-52 (10.7%) and HPV-51 (10.6%) were the most common genotypes in our population, being HPV-16 more frequent in women aged from 30 to 45 years and HPV-39 in 50-65 years. Results also show that HPV16/18 are present in 22.1% and HPV16/18/31/33/45/52/58 in 47.6% of HR-HPV positive women. This is the largest study on HR-HPV genotyping for Cervical Cancer Screening in European populations and provides critical data for program management and vaccine policy. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-08 2019-08-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/62312 |
url |
https://hdl.handle.net/1822/62312 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2405-8521 2405-8521 10.1016/j.pvr.2019.100179 31377173 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799132450168766464 |