PillCam COLON 2© in Crohn's disease: A new concept of pan-enteric mucosal healing assessment
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/40694 |
Resumo: | AIM To evaluate mucosal healing in patients with small bowel plus colonic Crohn's disease (CD) with a single non-invasive examination, by using PillCam COLON 2 (PCC2). METHODS Patients with non-stricturing nonpenetrating small bowel plus colonic CD in sustained corticosteroid-free remission were included. At diagnosis, patients had undergone ileocolonoscopy to identify active CD lesions, such as ulcers and erosions, and small bowel capsule endoscopy to assess the Lewis Score (LS). After = 1 year of follow-up, patients underwent entire gastrointestinal tract evaluation with PCC2. The primary endpoint was assessment of CD mucosal healing, defined as no active colonic CD lesions and LS < 135. RESULTS Twelve patients were included (7 male; mean age: 32 years), and mean follow-up was 38 mo. The majority of patients (83.3%) received immunosuppressive therapy. Three patients (25%) achieved mucosal healing in both the small bowel and the colon, while disease activity was limited to either the small bowel or the colon in 5 patients (42%). It was possible to observe the entire gastrointestinal tract in 10 of the 12 patients (83%) who underwent PCC2. CONCLUSION Only three patients in sustained corticosteroid-free clinical remission achieved mucosal healing in both the small bowel and the colon, highlighting the limitations of clinical assessment when stratifying disease activity, and the need for pan-enteric endoscopy to guide therapeutic modification. |
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PillCam COLON 2© in Crohn's disease: A new concept of pan-enteric mucosal healing assessmentCrohn’s diseaseMucosal healingCapsule endoscopySmall bowel diseasesInflammatory bowel diseaseAIM To evaluate mucosal healing in patients with small bowel plus colonic Crohn's disease (CD) with a single non-invasive examination, by using PillCam COLON 2 (PCC2). METHODS Patients with non-stricturing nonpenetrating small bowel plus colonic CD in sustained corticosteroid-free remission were included. At diagnosis, patients had undergone ileocolonoscopy to identify active CD lesions, such as ulcers and erosions, and small bowel capsule endoscopy to assess the Lewis Score (LS). After = 1 year of follow-up, patients underwent entire gastrointestinal tract evaluation with PCC2. The primary endpoint was assessment of CD mucosal healing, defined as no active colonic CD lesions and LS < 135. RESULTS Twelve patients were included (7 male; mean age: 32 years), and mean follow-up was 38 mo. The majority of patients (83.3%) received immunosuppressive therapy. Three patients (25%) achieved mucosal healing in both the small bowel and the colon, while disease activity was limited to either the small bowel or the colon in 5 patients (42%). It was possible to observe the entire gastrointestinal tract in 10 of the 12 patients (83%) who underwent PCC2. CONCLUSION Only three patients in sustained corticosteroid-free clinical remission achieved mucosal healing in both the small bowel and the colon, highlighting the limitations of clinical assessment when stratifying disease activity, and the need for pan-enteric endoscopy to guide therapeutic modification.Baishideng Publishing GroupUniversidade do MinhoCarvalho, Pedro BoalRosa, B.De Castro, F. D.Moreira, M. J.Cotter, José20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/40694engCarvalho, P. B., Rosa, B., De Castro, F. D., Moreira, M. J., & Cotter, J. (2015). PillCam COLON 2© in Crohn's disease: A new concept of pan-enteric mucosal healing assessment. World Journal of Gastroenterology, 21(23), 7233-7241. doi: 10.3748/wjg.v21.i23.72331007-932710.3748/wjg.v21.i23.723http://www.wjgnet.cominfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:18:20Zoai:repositorium.sdum.uminho.pt:1822/40694Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:11:08.401843Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
PillCam COLON 2© in Crohn's disease: A new concept of pan-enteric mucosal healing assessment |
title |
PillCam COLON 2© in Crohn's disease: A new concept of pan-enteric mucosal healing assessment |
spellingShingle |
PillCam COLON 2© in Crohn's disease: A new concept of pan-enteric mucosal healing assessment Carvalho, Pedro Boal Crohn’s disease Mucosal healing Capsule endoscopy Small bowel diseases Inflammatory bowel disease |
title_short |
PillCam COLON 2© in Crohn's disease: A new concept of pan-enteric mucosal healing assessment |
title_full |
PillCam COLON 2© in Crohn's disease: A new concept of pan-enteric mucosal healing assessment |
title_fullStr |
PillCam COLON 2© in Crohn's disease: A new concept of pan-enteric mucosal healing assessment |
title_full_unstemmed |
PillCam COLON 2© in Crohn's disease: A new concept of pan-enteric mucosal healing assessment |
title_sort |
PillCam COLON 2© in Crohn's disease: A new concept of pan-enteric mucosal healing assessment |
author |
Carvalho, Pedro Boal |
author_facet |
Carvalho, Pedro Boal Rosa, B. De Castro, F. D. Moreira, M. J. Cotter, José |
author_role |
author |
author2 |
Rosa, B. De Castro, F. D. Moreira, M. J. Cotter, José |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Carvalho, Pedro Boal Rosa, B. De Castro, F. D. Moreira, M. J. Cotter, José |
dc.subject.por.fl_str_mv |
Crohn’s disease Mucosal healing Capsule endoscopy Small bowel diseases Inflammatory bowel disease |
topic |
Crohn’s disease Mucosal healing Capsule endoscopy Small bowel diseases Inflammatory bowel disease |
description |
AIM To evaluate mucosal healing in patients with small bowel plus colonic Crohn's disease (CD) with a single non-invasive examination, by using PillCam COLON 2 (PCC2). METHODS Patients with non-stricturing nonpenetrating small bowel plus colonic CD in sustained corticosteroid-free remission were included. At diagnosis, patients had undergone ileocolonoscopy to identify active CD lesions, such as ulcers and erosions, and small bowel capsule endoscopy to assess the Lewis Score (LS). After = 1 year of follow-up, patients underwent entire gastrointestinal tract evaluation with PCC2. The primary endpoint was assessment of CD mucosal healing, defined as no active colonic CD lesions and LS < 135. RESULTS Twelve patients were included (7 male; mean age: 32 years), and mean follow-up was 38 mo. The majority of patients (83.3%) received immunosuppressive therapy. Three patients (25%) achieved mucosal healing in both the small bowel and the colon, while disease activity was limited to either the small bowel or the colon in 5 patients (42%). It was possible to observe the entire gastrointestinal tract in 10 of the 12 patients (83%) who underwent PCC2. CONCLUSION Only three patients in sustained corticosteroid-free clinical remission achieved mucosal healing in both the small bowel and the colon, highlighting the limitations of clinical assessment when stratifying disease activity, and the need for pan-enteric endoscopy to guide therapeutic modification. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015 2015-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/40694 |
url |
http://hdl.handle.net/1822/40694 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Carvalho, P. B., Rosa, B., De Castro, F. D., Moreira, M. J., & Cotter, J. (2015). PillCam COLON 2© in Crohn's disease: A new concept of pan-enteric mucosal healing assessment. World Journal of Gastroenterology, 21(23), 7233-7241. doi: 10.3748/wjg.v21.i23.7233 1007-9327 10.3748/wjg.v21.i23.723 http://www.wjgnet.com |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Baishideng Publishing Group |
publisher.none.fl_str_mv |
Baishideng Publishing Group |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132542753832960 |