High Incidence of Early Thalamic Lesions in the Continuous Spike-Wave Related with Slow Sleep (CSWS)

Detalhes bibliográficos
Autor(a) principal: Carvalho, D
Data de Publicação: 2023
Outros Autores: Mendonça, C, Carvalho, J, Martins, A, Leal, A
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.17/4353
Resumo: Objective: Continuous Spike-Wave during slow Sleep (CSWS) syndrome associates a clinically important neurocognitive regression with strong activation of non-REM sleep spikes. Its mechanisms remain unknown, but a contribution of rare perinatal thalamic injuries has been highlighted. We determine the incidence of such lesions in a cohort of CSWS patients. Methods: N = 65 patients with CSWS and a control group (N = 51) were studied. Spikes were quantified in long-term ambulatory EEGs, brain Magnetic Ressonance Imaging (MRI) structural lesions were assessed and thalamic volumetry was performed. A neurocognitive scale was used to assess dysfunction. Results: The most common etiologies in the control patients were not represented in the CSWS group. Structural lesions were detected in a minority of CSWS patients (25/53) but included a thalamic injury in the large majority (24/25). This ratio was 4/40 in controls. Lesions belonged to one of five types: 1. Circumscribed to the thalamus (N = 11); 2. Extending beyond the thalamus (N = 3); 3. Hypothalamic-Hamartomas (N = 4); 4. Periventricular-Leukomalacia (N = 4); 5. Hypoplasia-Polymicrogyria (N = 1). Most lesions were lateralized to one hemisphere, which in all cases corresponded to the lateralization of the CSWS. Significance: Thalamic lesions are present in most CSWS patients with abnormal MRIs, supporting an important role in its genesis.
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spelling High Incidence of Early Thalamic Lesions in the Continuous Spike-Wave Related with Slow Sleep (CSWS)CSWSCSWSEpileptic EncephalopathyPediatric EpilepsyThalamusHDE NEU PEDObjective: Continuous Spike-Wave during slow Sleep (CSWS) syndrome associates a clinically important neurocognitive regression with strong activation of non-REM sleep spikes. Its mechanisms remain unknown, but a contribution of rare perinatal thalamic injuries has been highlighted. We determine the incidence of such lesions in a cohort of CSWS patients. Methods: N = 65 patients with CSWS and a control group (N = 51) were studied. Spikes were quantified in long-term ambulatory EEGs, brain Magnetic Ressonance Imaging (MRI) structural lesions were assessed and thalamic volumetry was performed. A neurocognitive scale was used to assess dysfunction. Results: The most common etiologies in the control patients were not represented in the CSWS group. Structural lesions were detected in a minority of CSWS patients (25/53) but included a thalamic injury in the large majority (24/25). This ratio was 4/40 in controls. Lesions belonged to one of five types: 1. Circumscribed to the thalamus (N = 11); 2. Extending beyond the thalamus (N = 3); 3. Hypothalamic-Hamartomas (N = 4); 4. Periventricular-Leukomalacia (N = 4); 5. Hypoplasia-Polymicrogyria (N = 1). Most lesions were lateralized to one hemisphere, which in all cases corresponded to the lateralization of the CSWS. Significance: Thalamic lesions are present in most CSWS patients with abnormal MRIs, supporting an important role in its genesis.ElsevierRepositório do Centro Hospitalar Universitário de Lisboa Central, EPECarvalho, DMendonça, CCarvalho, JMartins, ALeal, A2023-01-11T15:33:56Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/4353engEpilepsy Behav . 2023 Jan;138:10903110.1016/j.yebeh.2022.109031info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:46:15Zoai:repositorio.chlc.min-saude.pt:10400.17/4353Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:21:40.856271Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv High Incidence of Early Thalamic Lesions in the Continuous Spike-Wave Related with Slow Sleep (CSWS)
title High Incidence of Early Thalamic Lesions in the Continuous Spike-Wave Related with Slow Sleep (CSWS)
spellingShingle High Incidence of Early Thalamic Lesions in the Continuous Spike-Wave Related with Slow Sleep (CSWS)
Carvalho, D
CSWS
CSWS
Epileptic Encephalopathy
Pediatric Epilepsy
Thalamus
HDE NEU PED
title_short High Incidence of Early Thalamic Lesions in the Continuous Spike-Wave Related with Slow Sleep (CSWS)
title_full High Incidence of Early Thalamic Lesions in the Continuous Spike-Wave Related with Slow Sleep (CSWS)
title_fullStr High Incidence of Early Thalamic Lesions in the Continuous Spike-Wave Related with Slow Sleep (CSWS)
title_full_unstemmed High Incidence of Early Thalamic Lesions in the Continuous Spike-Wave Related with Slow Sleep (CSWS)
title_sort High Incidence of Early Thalamic Lesions in the Continuous Spike-Wave Related with Slow Sleep (CSWS)
author Carvalho, D
author_facet Carvalho, D
Mendonça, C
Carvalho, J
Martins, A
Leal, A
author_role author
author2 Mendonça, C
Carvalho, J
Martins, A
Leal, A
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE
dc.contributor.author.fl_str_mv Carvalho, D
Mendonça, C
Carvalho, J
Martins, A
Leal, A
dc.subject.por.fl_str_mv CSWS
CSWS
Epileptic Encephalopathy
Pediatric Epilepsy
Thalamus
HDE NEU PED
topic CSWS
CSWS
Epileptic Encephalopathy
Pediatric Epilepsy
Thalamus
HDE NEU PED
description Objective: Continuous Spike-Wave during slow Sleep (CSWS) syndrome associates a clinically important neurocognitive regression with strong activation of non-REM sleep spikes. Its mechanisms remain unknown, but a contribution of rare perinatal thalamic injuries has been highlighted. We determine the incidence of such lesions in a cohort of CSWS patients. Methods: N = 65 patients with CSWS and a control group (N = 51) were studied. Spikes were quantified in long-term ambulatory EEGs, brain Magnetic Ressonance Imaging (MRI) structural lesions were assessed and thalamic volumetry was performed. A neurocognitive scale was used to assess dysfunction. Results: The most common etiologies in the control patients were not represented in the CSWS group. Structural lesions were detected in a minority of CSWS patients (25/53) but included a thalamic injury in the large majority (24/25). This ratio was 4/40 in controls. Lesions belonged to one of five types: 1. Circumscribed to the thalamus (N = 11); 2. Extending beyond the thalamus (N = 3); 3. Hypothalamic-Hamartomas (N = 4); 4. Periventricular-Leukomalacia (N = 4); 5. Hypoplasia-Polymicrogyria (N = 1). Most lesions were lateralized to one hemisphere, which in all cases corresponded to the lateralization of the CSWS. Significance: Thalamic lesions are present in most CSWS patients with abnormal MRIs, supporting an important role in its genesis.
publishDate 2023
dc.date.none.fl_str_mv 2023-01-11T15:33:56Z
2023
2023-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.17/4353
url http://hdl.handle.net/10400.17/4353
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Epilepsy Behav . 2023 Jan;138:109031
10.1016/j.yebeh.2022.109031
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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