Cardiac magnetic resonance patterns of left ventricular remodeling in patients with severe aortic stenosis referred to surgical aortic valve replacement

Detalhes bibliográficos
Autor(a) principal: Reis Santos, Rita
Data de Publicação: 2024
Outros Autores: Abecasis, João, Maltês, Sérgio, Lopes, Pedro, Oliveira, Luís, Freitas, Pedro, Ferreira, António, Ribeiras, Regina, Andrade, Maria João, Sousa Uva, Miguel, Neves, José Pedro, Gil, Victor, Cardim, Nuno
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/166073
Resumo: Publisher Copyright: © The Author(s) 2024.
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spelling Cardiac magnetic resonance patterns of left ventricular remodeling in patients with severe aortic stenosis referred to surgical aortic valve replacementAortic stenosisCardiac magnetic resonanceLeft ventricular hypertrophy and remodelingGeneralPublisher Copyright: © The Author(s) 2024.Left ventricular (LV) hypertrophy is a common finding in patients with severe aortic stenosis (AS). Cardiac magnetic resonance (CMR) is the gold-standard technique to evaluate LV remodeling. Our aim was to assess the prevalence and describe the patterns of LV adaptation in AS patients before and after surgical aortic valve replacement (AVR). Prospective study of 130 consecutive patients (71y [IQR 68–77y], 48% men) with severe AS, referred for surgical AVR. Patterns of LV remodeling were assessed by CMR. Besides normal LV ventricular structure, four other patterns were considered: concentric remodeling, concentric hypertrophy, eccentric hypertrophy, and adverse remodeling. At baseline CMR study: mean LV indexed mass: 81.8 ± 26.7 g/m2; mean end-diastolic LV indexed volume: 85.7 ± 23.1 mL/m2 and median geometric remodeling ratio: 0.96 g/mL [IQR 0.82–1.08 g/mL]. LV hypertrophy occurred in 49% of subjects (concentric 44%; eccentric 5%). Both normal LV structure and concentric remodeling had a prevalence of 25% among the cohort; one patient had an adverse remodeling pattern. Asymmetric LV wall thickening was present in 55% of the patients, with predominant septal involvement. AVR was performed in 119 patients. At 3–6 months after AVR, LV remodeling changed to: normal ventricular geometry in 60%, concentric remodeling in 27%, concentric hypertrophy in 10%, eccentric hypertrophy in 3% and adverse remodeling (one patient). Indexes of AS severity, LV systolic and diastolic function and NT-proBNP were significantly different among the distinct patterns of remodeling. Several distinct patterns of LV remodelling beyond concentric hypertrophy occur in patients with classical severe AS. Asymmetric hypertrophy is a common finding and LV response after AVR is diverse.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNReis Santos, RitaAbecasis, JoãoMaltês, SérgioLopes, PedroOliveira, LuísFreitas, PedroFerreira, AntónioRibeiras, ReginaAndrade, Maria JoãoSousa Uva, MiguelNeves, José PedroGil, VictorCardim, Nuno2024-04-11T00:35:44Z2024-032024-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/166073eng2045-2322PURE: 87105803https://doi.org/10.1038/s41598-024-56838-0info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-10-21T01:37:10Zoai:run.unl.pt:10362/166073Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-10-21T01:37:10Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Cardiac magnetic resonance patterns of left ventricular remodeling in patients with severe aortic stenosis referred to surgical aortic valve replacement
title Cardiac magnetic resonance patterns of left ventricular remodeling in patients with severe aortic stenosis referred to surgical aortic valve replacement
spellingShingle Cardiac magnetic resonance patterns of left ventricular remodeling in patients with severe aortic stenosis referred to surgical aortic valve replacement
Reis Santos, Rita
Aortic stenosis
Cardiac magnetic resonance
Left ventricular hypertrophy and remodeling
General
title_short Cardiac magnetic resonance patterns of left ventricular remodeling in patients with severe aortic stenosis referred to surgical aortic valve replacement
title_full Cardiac magnetic resonance patterns of left ventricular remodeling in patients with severe aortic stenosis referred to surgical aortic valve replacement
title_fullStr Cardiac magnetic resonance patterns of left ventricular remodeling in patients with severe aortic stenosis referred to surgical aortic valve replacement
title_full_unstemmed Cardiac magnetic resonance patterns of left ventricular remodeling in patients with severe aortic stenosis referred to surgical aortic valve replacement
title_sort Cardiac magnetic resonance patterns of left ventricular remodeling in patients with severe aortic stenosis referred to surgical aortic valve replacement
author Reis Santos, Rita
author_facet Reis Santos, Rita
Abecasis, João
Maltês, Sérgio
Lopes, Pedro
Oliveira, Luís
Freitas, Pedro
Ferreira, António
Ribeiras, Regina
Andrade, Maria João
Sousa Uva, Miguel
Neves, José Pedro
Gil, Victor
Cardim, Nuno
author_role author
author2 Abecasis, João
Maltês, Sérgio
Lopes, Pedro
Oliveira, Luís
Freitas, Pedro
Ferreira, António
Ribeiras, Regina
Andrade, Maria João
Sousa Uva, Miguel
Neves, José Pedro
Gil, Victor
Cardim, Nuno
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Reis Santos, Rita
Abecasis, João
Maltês, Sérgio
Lopes, Pedro
Oliveira, Luís
Freitas, Pedro
Ferreira, António
Ribeiras, Regina
Andrade, Maria João
Sousa Uva, Miguel
Neves, José Pedro
Gil, Victor
Cardim, Nuno
dc.subject.por.fl_str_mv Aortic stenosis
Cardiac magnetic resonance
Left ventricular hypertrophy and remodeling
General
topic Aortic stenosis
Cardiac magnetic resonance
Left ventricular hypertrophy and remodeling
General
description Publisher Copyright: © The Author(s) 2024.
publishDate 2024
dc.date.none.fl_str_mv 2024-04-11T00:35:44Z
2024-03
2024-03-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/166073
url http://hdl.handle.net/10362/166073
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2045-2322
PURE: 87105803
https://doi.org/10.1038/s41598-024-56838-0
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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