The Impact of Donor Risk Index, Recipients' and Operative Characteristics on Post Liver Transplant One-Year Graft Failure

Detalhes bibliográficos
Autor(a) principal: Cardoso, Filipe S.
Data de Publicação: 2022
Outros Autores: Bagulho, Luis, Coelho, João S., Lamelas, Jorge, Mateus, Élia, Mendes, Milena, Glória, Helena, Ribeiro, Vasco, Mega, Raquel, Pena, Ana, Marques, Hugo P., Germano, Nuno, Nolasco, Fernando, Perdigoto, Rui, Martins, Américo Rodrigues
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/143906
Resumo: Publisher Copyright: © 2022
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spelling The Impact of Donor Risk Index, Recipients' and Operative Characteristics on Post Liver Transplant One-Year Graft FailureA Cohort AnalysisLiverOrgan donorTransplantationGastroenterologyPublisher Copyright: © 2022Background and Aims: The donor risk index (DRI) quantifies donor-related characteristics potentially associated with increased risk of early graft failure. We aimed to assess the impact of the DRI, recipient and perioperative factors on post liver transplant (LT) outcomes. Methods: This was a single-center retrospective cohort study including all adult (≥18 years) patients who underwent LT from 01/2019 to 12/2019 at Curry Cabral Hospital, Lisbon, Portugal. Primary endpoint was 1-year graft failure post LT. Associations were studied with logistic regression. Results: A total of 131 cadaveric donor LT procedures were performed in 116 recipients. Recipients' median (IQR) age was 57 (47-64) years and 101/131 (77.1%) were males. Cirrhosis was the underlying etiology in 95/131 (81.2%) transplants. Based on 8 predefined donors' characteristics, median (IQR) DRI was 1.96 (1.67-2.16). Following adjustment for MELDNa score pre LT and SOFA score (adjusted odds ratio [aOR], 95% confidence interval [CI] = 0.91 [0.56-1.47]) or lactate (aOR [95% CI] = 2.76 [0.71-10.7]) upon intensive care unit (ICU) admission post LT, DRI was not associated with 1-year graft failure. However, higher SOFA score (aOR [95% CI] = 1.20 [1.05-1.37]) or lactate (aOR [95% CI] = 1.27 [1.10-1.46]) upon ICU admission post LT were independently associated with higher odds of 1-year graft failure. Conclusions: In a recent cohort of patients who underwent LT, DRI, despite being high, was not associated with 1-year graft failure, but SOFA score or lactate upon ICU admission post LT were.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNCardoso, Filipe S.Bagulho, LuisCoelho, João S.Lamelas, JorgeMateus, ÉliaMendes, MilenaGlória, HelenaRibeiro, VascoMega, RaquelPena, AnaMarques, Hugo P.Germano, NunoNolasco, FernandoPerdigoto, RuiMartins, Américo Rodrigues2022-09-21T22:22:52Z2023-08-282023-08-28T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/143906eng2341-4545PURE: 44413118https://doi.org/10.1159/000524421info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:22:46Zoai:run.unl.pt:10362/143906Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:51:12.333141Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The Impact of Donor Risk Index, Recipients' and Operative Characteristics on Post Liver Transplant One-Year Graft Failure
A Cohort Analysis
title The Impact of Donor Risk Index, Recipients' and Operative Characteristics on Post Liver Transplant One-Year Graft Failure
spellingShingle The Impact of Donor Risk Index, Recipients' and Operative Characteristics on Post Liver Transplant One-Year Graft Failure
Cardoso, Filipe S.
Liver
Organ donor
Transplantation
Gastroenterology
title_short The Impact of Donor Risk Index, Recipients' and Operative Characteristics on Post Liver Transplant One-Year Graft Failure
title_full The Impact of Donor Risk Index, Recipients' and Operative Characteristics on Post Liver Transplant One-Year Graft Failure
title_fullStr The Impact of Donor Risk Index, Recipients' and Operative Characteristics on Post Liver Transplant One-Year Graft Failure
title_full_unstemmed The Impact of Donor Risk Index, Recipients' and Operative Characteristics on Post Liver Transplant One-Year Graft Failure
title_sort The Impact of Donor Risk Index, Recipients' and Operative Characteristics on Post Liver Transplant One-Year Graft Failure
author Cardoso, Filipe S.
author_facet Cardoso, Filipe S.
Bagulho, Luis
Coelho, João S.
Lamelas, Jorge
Mateus, Élia
Mendes, Milena
Glória, Helena
Ribeiro, Vasco
Mega, Raquel
Pena, Ana
Marques, Hugo P.
Germano, Nuno
Nolasco, Fernando
Perdigoto, Rui
Martins, Américo Rodrigues
author_role author
author2 Bagulho, Luis
Coelho, João S.
Lamelas, Jorge
Mateus, Élia
Mendes, Milena
Glória, Helena
Ribeiro, Vasco
Mega, Raquel
Pena, Ana
Marques, Hugo P.
Germano, Nuno
Nolasco, Fernando
Perdigoto, Rui
Martins, Américo Rodrigues
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Cardoso, Filipe S.
Bagulho, Luis
Coelho, João S.
Lamelas, Jorge
Mateus, Élia
Mendes, Milena
Glória, Helena
Ribeiro, Vasco
Mega, Raquel
Pena, Ana
Marques, Hugo P.
Germano, Nuno
Nolasco, Fernando
Perdigoto, Rui
Martins, Américo Rodrigues
dc.subject.por.fl_str_mv Liver
Organ donor
Transplantation
Gastroenterology
topic Liver
Organ donor
Transplantation
Gastroenterology
description Publisher Copyright: © 2022
publishDate 2022
dc.date.none.fl_str_mv 2022-09-21T22:22:52Z
2023-08-28
2023-08-28T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/143906
url http://hdl.handle.net/10362/143906
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2341-4545
PURE: 44413118
https://doi.org/10.1159/000524421
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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