Evaluation of commercial myxomatosis vaccines against recombinant myxoma virus (ha-MYXV) in Iberian hare and wild rabbit
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.5/24254 |
Resumo: | Research Areas: Immunology ; Research & Experimental Medicine |
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Evaluation of commercial myxomatosis vaccines against recombinant myxoma virus (ha-MYXV) in Iberian hare and wild rabbitMyxomatosisIberian hareEuropean wild rabbitvaccinesha-MYXVResearch Areas: Immunology ; Research & Experimental MedicineThe recent emergence of a new myxoma virus capable of causing disease in the Iberian hare (Lepus granatensis) has resulted in numerous outbreaks with high mortality leading to the reduction, or even the disappearance, of many local populations of this wild species in the Iberian Peninsula. Currently, the available vaccines that prevent myxomatosis in domestic rabbits caused by classic strains of myxoma virus have not been assessed for use in Iberian hares. The main objective of this study was to evaluate the efficacy of commercial rabbit vaccines in Iberian hares and wild rabbits against the natural recombinant myxoma virus (ha-MYXV), bearing in mind its application in specific scenarios where capture is possible, such as genetic reserves. The study used a limited number of animals (pilot study), 15 Iberian hares and 10 wild rabbits. Hares were vaccinated with Mixohipra-FSA vaccine (Hipra) and Mixohipra-H vaccine (Hipra) using two different doses, and rabbits were vaccinated with the Mixohipra-H vaccine or the Nobivac Myxo-RHD PLUS (MSD Animal Health) using the recommended doses for domestic rabbits. After the vaccination trials, the animals were challenged with a wild type strain of ha-MYXV. The results showed that no protection to ha-MYXV challenge was afforded when a commercial dose of Mixohipra-FSA or Mixohipra-H vaccine was used in hares. However, the application of a higher dose of Mixohipra-FSA vaccine may induce protection and could possibly be used to counteract the accelerated decrease of wild hare populations due to ha-MYXV emergence. The two commercial vaccines (Mixohipra-H and Nobivac Myxo-RHD PLUS) tested in wild rabbits were fully protective against ha-MYXV infection. This knowledge gives more insights into ha-MYXV management in hares and rabbits and emphasises the importance of developing a vaccine capable of protecting wild populations of Iberian hare and wild rabbit towards MYXV and ha-MYXV strainsMDPIRepositório da Universidade de LisboaAbade Dos Santos, F.A.Carvalho, CarinaValente, PamelaArmes, HenriqueReemers, Sylvia S.Peleteiro, Maria C.Calonge Sanz, InesDalton, Kevin P.Parra, FranciscoM. Duarte, M. D. Duarte, M. M. Duarte2022-05-08T22:57:56Z2022-02-242022-02-24T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/24254engAbade dos Santos, FA, Carvalho CL, Valente PCLG, Armés H, Reemers SS, Peleteiro MC, Calonge Sanz I, Dalton KP, Parra F, Duarte MD. 2022. Evaluation of commercial myxomatosis vaccines against recombinant myxoma virus (ha-MYXV) in Iberian hare and wild rabbit. Vaccines, 10(3):356. Doi 10.3390/vaccines1003035610.3390/vaccines100303562076-393Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-06T14:53:54Zoai:www.repository.utl.pt:10400.5/24254Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:08:20.909379Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Evaluation of commercial myxomatosis vaccines against recombinant myxoma virus (ha-MYXV) in Iberian hare and wild rabbit |
| title |
Evaluation of commercial myxomatosis vaccines against recombinant myxoma virus (ha-MYXV) in Iberian hare and wild rabbit |
| spellingShingle |
Evaluation of commercial myxomatosis vaccines against recombinant myxoma virus (ha-MYXV) in Iberian hare and wild rabbit Abade Dos Santos, F.A. MyxomatosisIberian hare European wild rabbit vaccines ha-MYXV |
| title_short |
Evaluation of commercial myxomatosis vaccines against recombinant myxoma virus (ha-MYXV) in Iberian hare and wild rabbit |
| title_full |
Evaluation of commercial myxomatosis vaccines against recombinant myxoma virus (ha-MYXV) in Iberian hare and wild rabbit |
| title_fullStr |
Evaluation of commercial myxomatosis vaccines against recombinant myxoma virus (ha-MYXV) in Iberian hare and wild rabbit |
| title_full_unstemmed |
Evaluation of commercial myxomatosis vaccines against recombinant myxoma virus (ha-MYXV) in Iberian hare and wild rabbit |
| title_sort |
Evaluation of commercial myxomatosis vaccines against recombinant myxoma virus (ha-MYXV) in Iberian hare and wild rabbit |
| author |
Abade Dos Santos, F.A. |
| author_facet |
Abade Dos Santos, F.A. Carvalho, Carina Valente, Pamela Armes, Henrique Reemers, Sylvia S. Peleteiro, Maria C. Calonge Sanz, Ines Dalton, Kevin P. Parra, Francisco M. Duarte, M. D. Duarte, M. M. Duarte |
| author_role |
author |
| author2 |
Carvalho, Carina Valente, Pamela Armes, Henrique Reemers, Sylvia S. Peleteiro, Maria C. Calonge Sanz, Ines Dalton, Kevin P. Parra, Francisco M. Duarte, M. D. Duarte, M. M. Duarte |
| author2_role |
author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Abade Dos Santos, F.A. Carvalho, Carina Valente, Pamela Armes, Henrique Reemers, Sylvia S. Peleteiro, Maria C. Calonge Sanz, Ines Dalton, Kevin P. Parra, Francisco M. Duarte, M. D. Duarte, M. M. Duarte |
| dc.subject.por.fl_str_mv |
MyxomatosisIberian hare European wild rabbit vaccines ha-MYXV |
| topic |
MyxomatosisIberian hare European wild rabbit vaccines ha-MYXV |
| description |
Research Areas: Immunology ; Research & Experimental Medicine |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-05-08T22:57:56Z 2022-02-24 2022-02-24T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
| format |
article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.5/24254 |
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http://hdl.handle.net/10400.5/24254 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Abade dos Santos, FA, Carvalho CL, Valente PCLG, Armés H, Reemers SS, Peleteiro MC, Calonge Sanz I, Dalton KP, Parra F, Duarte MD. 2022. Evaluation of commercial myxomatosis vaccines against recombinant myxoma virus (ha-MYXV) in Iberian hare and wild rabbit. Vaccines, 10(3):356. Doi 10.3390/vaccines10030356 10.3390/vaccines10030356 2076-393X |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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MDPI |
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MDPI |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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