LINEAR IMMUNOGLOBULIN A BULLOUS DERMATOSIS IN A PATIENT WITH ULCERATIVE COLITIS – A RARE BUT ESTABLISHED ASSOCIATION

• Autor(a) principal: Fernandes Massa, António
• Data de Publicação: 2015
• Outros Autores: Moreira, Catarina, Lisboa, Cármen, Santos, Paulo, Pardal, Joana, Azevedo, Filomena
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: https://doi.org/10.29021/spdv.72.4.331
• topic: Linear IgA bullous dermatosis; Skin diseases; Vesiculobullous; Ulcerative colitis; Inflammatory bowel disease; Dermatose bolhosa IgA linear; Vesicobolhosa; Doenças da pele; Colite ulcerosa; Doença inflamatória intestinal

The association of linear IgA bullous dermatosis (LABD) with ulcerative colitis (UC) is defined, although the etiology of this association is still unclear. We report the case of a 41 year-old female patient with UC diagnosed 6 years ago with a crisis 2 months ago, referred for pruriginous and tense bullae with 1 month of evolution. Her past medical history was relevant for gestational diabetes, reactive depression and hypertension. She was medicated with mesalazine for 1,5 years, bisoprolol, mexazolam and drospirenone/ethinyl estradiol. Cutaneous biopsy showed a bulla on the dermoepidermal junction (DEJ) and a polymorphous inflammatory dermal infiltrate. Linear immunoreactivity for IgA on the DEJ confirmed the diagnosis of LABD. Prednisolone and dapsone were initiated with good clinical response, maintained after six months of follow-up. The aetiology of this association remains unknown, being hypothesised cross-reactivity of IgA idiotype from UC with the dermoepidermal antigens. Mesalazine imputability cannot be surely ruledout as the cause of LABD in this patient.