Factors that influence the stability of the 18F-FDG

Detalhes bibliográficos
Autor(a) principal: Graça, Ana
Data de Publicação: 2011
Outros Autores: Sánchez Sánchez, Román, Garcia Bernardo, Lucía, Rayo Madrid, Juan, Lucena, Filipa
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.25758/set.354
Resumo: Introduction – The absence of a cyclotron for the production of 2 - [18F] Fluor-2-deoxy-D-glucose (18F-FDG) is now a reality for most of the centers where Positron Emission Tomography (TEP) exams are held for. It is therefore important to ensure the quality of this radiopharmaceutical from the moment of its synthesis till its administration to the patient. The purpose of this study is to show the influence of the parameters temperature, pH, radioactive concentration (CR), and time in radiochemical purity. Methodology – We analyzed the pH and the radiochemical purity [by thin layer chromatography (TLC)] of six samples of 18F-FDG with different CR and at different times and temperatures. Results – There was an increase in the percentage of 18F with time. Nevertheless, results show that sample dilution decreases the degradation of 18F-FDG. However, comparing only the diluted samples (185 and 740 MBq / ml), there is a positive relationship between CR and the percentage of 18F. There was also an increase in the percentage of 18F at higher temperatures. Conclusion – We advise diluting the solution and the period of time for storage of the 18F-FDG should not be so long. The samples must have a stable temperature and pH.
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spelling Factors that influence the stability of the 18F-FDGFactores que influenciam a estabilidade da 18F-FDG18F-FDGPureza radioquímicaAutoradiólisePercentagem de 18F18F-FDGRadiochemical purityAutoradiolysePercentage of 18FIntroduction – The absence of a cyclotron for the production of 2 - [18F] Fluor-2-deoxy-D-glucose (18F-FDG) is now a reality for most of the centers where Positron Emission Tomography (TEP) exams are held for. It is therefore important to ensure the quality of this radiopharmaceutical from the moment of its synthesis till its administration to the patient. The purpose of this study is to show the influence of the parameters temperature, pH, radioactive concentration (CR), and time in radiochemical purity. Methodology – We analyzed the pH and the radiochemical purity [by thin layer chromatography (TLC)] of six samples of 18F-FDG with different CR and at different times and temperatures. Results – There was an increase in the percentage of 18F with time. Nevertheless, results show that sample dilution decreases the degradation of 18F-FDG. However, comparing only the diluted samples (185 and 740 MBq / ml), there is a positive relationship between CR and the percentage of 18F. There was also an increase in the percentage of 18F at higher temperatures. Conclusion – We advise diluting the solution and the period of time for storage of the 18F-FDG should not be so long. The samples must have a stable temperature and pH.Introdução – A ausência de um ciclotrão para produção da 2-[18F]Flúor-2-deoxi-D-glucose (18F-FDG) é, actualmente, uma realidade para a maior parte dos centros onde se realizam exames de Tomografia por Emissão de Positrões (TEP),  sendo  importante garantir a qualidade deste radiofármaco desde o momento da sua síntese até à administração ao doente. O objectivo do estudo é demonstrar a influência dos parâmetros temperatura, pH, concentração radioactiva (CR) e tempo na pureza radioquímica da 18F-FDG. Metodologia – Analisou-se o pH e a pureza radioquímica [por cromatografia em camada fina (CCF)] de seis amostras de 18F-FDG com diferentes CR e em diferentes tempos e temperaturas. Resultados – Registou-se um aumento da percentagem de 18F- aquando do aumento do tempo. Contudo, os resultados não comprovam que a diluição das amostras diminui a degradação do 18F-FDG. No entanto, comparando apenas as amostras diluídas (185 e 740 MBq/ml), observa-se uma relação positiva entre a CR e a percentagem de 18F-. Verificou-se ainda um aumento da percentagem de 18F- nas temperaturas mais elevadas. Conclusão – Sugere-se a diluição das amostras de 18F-FDG e que o tempo de armazenamento não seja muito longo. As amostras devem ainda encontrar-se a temperatura e pH estáveis.Escola Superior de Tecnologia da Saúde de Lisboa (Instituto Politécnico de Lisboa)2011-05-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.25758/set.354https://doi.org/10.25758/set.354Saúde e Tecnologia; No. 05 (2011): Maio 2011; 35-38Saúde & Tecnologia; N.º 05 (2011): Maio 2011; 35-381646-9704reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://journals.ipl.pt/stecnologia/article/view/709https://journals.ipl.pt/stecnologia/article/view/709/604Direitos de Autor (c) 2022 Saúde & Tecnologiainfo:eu-repo/semantics/openAccessGraça, AnaSánchez Sánchez, RománGarcia Bernardo, LucíaRayo Madrid, JuanLucena, Filipa2023-01-13T08:30:15Zoai:journals.ipl.pt:article/709Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:21:30.525550Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Factors that influence the stability of the 18F-FDG
Factores que influenciam a estabilidade da 18F-FDG
title Factors that influence the stability of the 18F-FDG
spellingShingle Factors that influence the stability of the 18F-FDG
Graça, Ana
18F-FDG
Pureza radioquímica
Autoradiólise
Percentagem de 18F
18F-FDG
Radiochemical purity
Autoradiolyse
Percentage of 18F
title_short Factors that influence the stability of the 18F-FDG
title_full Factors that influence the stability of the 18F-FDG
title_fullStr Factors that influence the stability of the 18F-FDG
title_full_unstemmed Factors that influence the stability of the 18F-FDG
title_sort Factors that influence the stability of the 18F-FDG
author Graça, Ana
author_facet Graça, Ana
Sánchez Sánchez, Román
Garcia Bernardo, Lucía
Rayo Madrid, Juan
Lucena, Filipa
author_role author
author2 Sánchez Sánchez, Román
Garcia Bernardo, Lucía
Rayo Madrid, Juan
Lucena, Filipa
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Graça, Ana
Sánchez Sánchez, Román
Garcia Bernardo, Lucía
Rayo Madrid, Juan
Lucena, Filipa
dc.subject.por.fl_str_mv 18F-FDG
Pureza radioquímica
Autoradiólise
Percentagem de 18F
18F-FDG
Radiochemical purity
Autoradiolyse
Percentage of 18F
topic 18F-FDG
Pureza radioquímica
Autoradiólise
Percentagem de 18F
18F-FDG
Radiochemical purity
Autoradiolyse
Percentage of 18F
description Introduction – The absence of a cyclotron for the production of 2 - [18F] Fluor-2-deoxy-D-glucose (18F-FDG) is now a reality for most of the centers where Positron Emission Tomography (TEP) exams are held for. It is therefore important to ensure the quality of this radiopharmaceutical from the moment of its synthesis till its administration to the patient. The purpose of this study is to show the influence of the parameters temperature, pH, radioactive concentration (CR), and time in radiochemical purity. Methodology – We analyzed the pH and the radiochemical purity [by thin layer chromatography (TLC)] of six samples of 18F-FDG with different CR and at different times and temperatures. Results – There was an increase in the percentage of 18F with time. Nevertheless, results show that sample dilution decreases the degradation of 18F-FDG. However, comparing only the diluted samples (185 and 740 MBq / ml), there is a positive relationship between CR and the percentage of 18F. There was also an increase in the percentage of 18F at higher temperatures. Conclusion – We advise diluting the solution and the period of time for storage of the 18F-FDG should not be so long. The samples must have a stable temperature and pH.
publishDate 2011
dc.date.none.fl_str_mv 2011-05-15
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.25758/set.354
https://doi.org/10.25758/set.354
url https://doi.org/10.25758/set.354
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://journals.ipl.pt/stecnologia/article/view/709
https://journals.ipl.pt/stecnologia/article/view/709/604
dc.rights.driver.fl_str_mv Direitos de Autor (c) 2022 Saúde & Tecnologia
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Direitos de Autor (c) 2022 Saúde & Tecnologia
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Escola Superior de Tecnologia da Saúde de Lisboa (Instituto Politécnico de Lisboa)
publisher.none.fl_str_mv Escola Superior de Tecnologia da Saúde de Lisboa (Instituto Politécnico de Lisboa)
dc.source.none.fl_str_mv Saúde e Tecnologia; No. 05 (2011): Maio 2011; 35-38
Saúde & Tecnologia; N.º 05 (2011): Maio 2011; 35-38
1646-9704
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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