Electrochemical determination of citalopram by adsorptive stripping voltammetry–determination in pharmaceutical products

Detalhes bibliográficos
Autor(a) principal: Nouws, Henri P. A.
Data de Publicação: 2006
Outros Autores: Delerue-Matos, Cristina, Barros, Aquiles A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.22/2969
Resumo: The electrochemical behavior of citalopram was studied by square-wave and square-wave adsorptive-stripping voltammetry (SWAdSV). Citalopram can be reduced and accumulated at a mercury drop electrode, with a maximum peak current intensity being obtained at a potential of approximately -1.25V vs. AgCl/Ag, in an aqueous electrolyte solution of pH 12. A SWAdSV method has been developed for the determination of citalopram in pharmaceutical preparations. The method shows a linear range between 1.0x10-7 and 2.0x10-6 mol L-1 with a limit of detection of 5x10-8 mol L-1 for an accumulation time of 30 s. The precision of the method was evaluated by assessing the repeatability and intermediate precision, achieving good relative standard deviations in all cases (≤2.3%). The proposed method was applied to the determination of citalopram in five pharmaceutical products and the results obtained are in good agreement with the labeled values.
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spelling Electrochemical determination of citalopram by adsorptive stripping voltammetry–determination in pharmaceutical productsCitalopramSSRIHanging mercury drop electrodeAdsorptive-stripping voltammetryPharmaceutical analysisThe electrochemical behavior of citalopram was studied by square-wave and square-wave adsorptive-stripping voltammetry (SWAdSV). Citalopram can be reduced and accumulated at a mercury drop electrode, with a maximum peak current intensity being obtained at a potential of approximately -1.25V vs. AgCl/Ag, in an aqueous electrolyte solution of pH 12. A SWAdSV method has been developed for the determination of citalopram in pharmaceutical preparations. The method shows a linear range between 1.0x10-7 and 2.0x10-6 mol L-1 with a limit of detection of 5x10-8 mol L-1 for an accumulation time of 30 s. The precision of the method was evaluated by assessing the repeatability and intermediate precision, achieving good relative standard deviations in all cases (≤2.3%). The proposed method was applied to the determination of citalopram in five pharmaceutical products and the results obtained are in good agreement with the labeled values.Taylor & FrancisRepositório Científico do Instituto Politécnico do PortoNouws, Henri P. A.Delerue-Matos, CristinaBarros, Aquiles A.2013-11-26T16:54:19Z20062006-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/2969eng0003-271910.1080/00032710600721712info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T12:42:36Zoai:recipp.ipp.pt:10400.22/2969Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:23:59.576080Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Electrochemical determination of citalopram by adsorptive stripping voltammetry–determination in pharmaceutical products
title Electrochemical determination of citalopram by adsorptive stripping voltammetry–determination in pharmaceutical products
spellingShingle Electrochemical determination of citalopram by adsorptive stripping voltammetry–determination in pharmaceutical products
Nouws, Henri P. A.
Citalopram
SSRI
Hanging mercury drop electrode
Adsorptive-stripping voltammetry
Pharmaceutical analysis
title_short Electrochemical determination of citalopram by adsorptive stripping voltammetry–determination in pharmaceutical products
title_full Electrochemical determination of citalopram by adsorptive stripping voltammetry–determination in pharmaceutical products
title_fullStr Electrochemical determination of citalopram by adsorptive stripping voltammetry–determination in pharmaceutical products
title_full_unstemmed Electrochemical determination of citalopram by adsorptive stripping voltammetry–determination in pharmaceutical products
title_sort Electrochemical determination of citalopram by adsorptive stripping voltammetry–determination in pharmaceutical products
author Nouws, Henri P. A.
author_facet Nouws, Henri P. A.
Delerue-Matos, Cristina
Barros, Aquiles A.
author_role author
author2 Delerue-Matos, Cristina
Barros, Aquiles A.
author2_role author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico do Porto
dc.contributor.author.fl_str_mv Nouws, Henri P. A.
Delerue-Matos, Cristina
Barros, Aquiles A.
dc.subject.por.fl_str_mv Citalopram
SSRI
Hanging mercury drop electrode
Adsorptive-stripping voltammetry
Pharmaceutical analysis
topic Citalopram
SSRI
Hanging mercury drop electrode
Adsorptive-stripping voltammetry
Pharmaceutical analysis
description The electrochemical behavior of citalopram was studied by square-wave and square-wave adsorptive-stripping voltammetry (SWAdSV). Citalopram can be reduced and accumulated at a mercury drop electrode, with a maximum peak current intensity being obtained at a potential of approximately -1.25V vs. AgCl/Ag, in an aqueous electrolyte solution of pH 12. A SWAdSV method has been developed for the determination of citalopram in pharmaceutical preparations. The method shows a linear range between 1.0x10-7 and 2.0x10-6 mol L-1 with a limit of detection of 5x10-8 mol L-1 for an accumulation time of 30 s. The precision of the method was evaluated by assessing the repeatability and intermediate precision, achieving good relative standard deviations in all cases (≤2.3%). The proposed method was applied to the determination of citalopram in five pharmaceutical products and the results obtained are in good agreement with the labeled values.
publishDate 2006
dc.date.none.fl_str_mv 2006
2006-01-01T00:00:00Z
2013-11-26T16:54:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.22/2969
url http://hdl.handle.net/10400.22/2969
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0003-2719
10.1080/00032710600721712
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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