Inflammatory biomarkers and perinatal depression: a systematic review
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | https://hdl.handle.net/1822/84289 |
Resumo: | This article is a preprint and has not been peer-reviewed [what does this mean?]. It reports new medical research that has yet to be evaluated and so should not be used to guide clinical practice. |
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Inflammatory biomarkers and perinatal depression: a systematic reviewDepressionPregnancyPostpartumPerinatalImmune systemBiomarkersCytokinesInflammationCiências Sociais::PsicologiaThis article is a preprint and has not been peer-reviewed [what does this mean?]. It reports new medical research that has yet to be evaluated and so should not be used to guide clinical practice.Background: Approximately 10 to 20% of pregnant women worldwide experience perinatal depression (PND), a depressive episode with onset during pregnancy or after childbirth. We performed a systematic review to identify, summarize and discuss studies on inflammatory biomarkers described in relation to PND. Methods: Inclusion criteria defined the selection of observational studies written in English, French, Spanish or Portuguese, that evaluate analytical levels of inflammatory molecules (protein levels) in biological fluids in women, with a diagnosis of depression using ICD/DSM diagnostic criteria or depressive symptoms assessed by standardized psychometric instruments, during pregnancy and/or postpartum. Case reports, experimental studies, reviews, qualitative analysis, meta-analysis, gray literature or replicated data were excluded. Three electronic databases were used for search (Pubmed, Web of Science and PsychInfo) and quality assessment of selected studies were performed using the Newcastle-Ottawa Scale. Data extraction included study design; number of subjects; obstetric information; tools and timepoints of depression and inflammatory markers assessment. Results: 56 studies where the major aim was to analyze the association between depression and inflammatory biomarkers during pregnancy and postpartum period were included in this systematic review. Overall, the findings of our systematic review lend support to the hypothesis that several inflammatory markers may be associated with peripartum depressive symptoms. The associations were somewhat different looking at pregnancy compared to the delivery time-point and postpartum, and mainly referred to increased levels of IL-6, IL-8, CRP and TNF-α among depressed. Discussion: Our results revealed high heterogeneity in relation to the timing of biological sampling for markers, as well as timing and instruments used for depression assessment within the perinatal period for the different studies. Studies differed also in relation to use of biomarkers or depression as exposure and outcome respectively, and whether these were addressed at the same timepoint or separate ones. Given the high burden of PND on women, children and families, it is crucial to try to harmonize methods used in related studies, in order to be able to pool results that could give us insights into the pathophysiological mechanisms behind how the immune system and PND are connected; this could have great impact on early detection, prevention and even treatment of PND.AS-F was supported by the Portuguese Foundation for Science and Technology and the Portuguese Ministry of Science, Technology and Higher Education, through the national funds, within the scope of the Transitory Disposition of the Decree No. 57/2016, of 29th of August, amended by Law No. 57/2017 of 19 July and previously through the fellowship grant SFRH/BPD/107732/2015. This paper is part of the COST Action Riseup-PPD CA18138 and was supported by COST under COST Action Riseup-PPD CA18138 (Virtual Mobility Grant).Cold Spring Harbor LaboratoryUniversidade do MinhoSilva-Fernandes, AnabelaConde, AnaMarques, MargaridaCaparros-Gonzalez, Rafael A.Fransson, EmmaMesquita, Ana Raquel MarcelinoFigueiredo, BárbaraSkalkidou, Alkistis2023-01-112023-01-11T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/84289engSilva-Fernandes, A., Conde, A., Marques, M., Caparros-Gonzalez, R. A., Fransson, E., Mesquita, A. R., ... & Skalkidou, A. (2023). Inflammatory biomarkers and perinatal depression: a systematic review. medRxiv, 2023-01.10.1101/2023.01.11.23284231https://www.medrxiv.org/content/10.1101/2023.01.11.23284231v1info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:07:06Zoai:repositorium.sdum.uminho.pt:1822/84289Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:57:57.101488Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Inflammatory biomarkers and perinatal depression: a systematic review |
| title |
Inflammatory biomarkers and perinatal depression: a systematic review |
| spellingShingle |
Inflammatory biomarkers and perinatal depression: a systematic review Silva-Fernandes, Anabela Depression Pregnancy Postpartum Perinatal Immune system Biomarkers Cytokines Inflammation Ciências Sociais::Psicologia |
| title_short |
Inflammatory biomarkers and perinatal depression: a systematic review |
| title_full |
Inflammatory biomarkers and perinatal depression: a systematic review |
| title_fullStr |
Inflammatory biomarkers and perinatal depression: a systematic review |
| title_full_unstemmed |
Inflammatory biomarkers and perinatal depression: a systematic review |
| title_sort |
Inflammatory biomarkers and perinatal depression: a systematic review |
| author |
Silva-Fernandes, Anabela |
| author_facet |
Silva-Fernandes, Anabela Conde, Ana Marques, Margarida Caparros-Gonzalez, Rafael A. Fransson, Emma Mesquita, Ana Raquel Marcelino Figueiredo, Bárbara Skalkidou, Alkistis |
| author_role |
author |
| author2 |
Conde, Ana Marques, Margarida Caparros-Gonzalez, Rafael A. Fransson, Emma Mesquita, Ana Raquel Marcelino Figueiredo, Bárbara Skalkidou, Alkistis |
| author2_role |
author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade do Minho |
| dc.contributor.author.fl_str_mv |
Silva-Fernandes, Anabela Conde, Ana Marques, Margarida Caparros-Gonzalez, Rafael A. Fransson, Emma Mesquita, Ana Raquel Marcelino Figueiredo, Bárbara Skalkidou, Alkistis |
| dc.subject.por.fl_str_mv |
Depression Pregnancy Postpartum Perinatal Immune system Biomarkers Cytokines Inflammation Ciências Sociais::Psicologia |
| topic |
Depression Pregnancy Postpartum Perinatal Immune system Biomarkers Cytokines Inflammation Ciências Sociais::Psicologia |
| description |
This article is a preprint and has not been peer-reviewed [what does this mean?]. It reports new medical research that has yet to be evaluated and so should not be used to guide clinical practice. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-01-11 2023-01-11T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/84289 |
| url |
https://hdl.handle.net/1822/84289 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Silva-Fernandes, A., Conde, A., Marques, M., Caparros-Gonzalez, R. A., Fransson, E., Mesquita, A. R., ... & Skalkidou, A. (2023). Inflammatory biomarkers and perinatal depression: a systematic review. medRxiv, 2023-01. 10.1101/2023.01.11.23284231 https://www.medrxiv.org/content/10.1101/2023.01.11.23284231v1 |
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info:eu-repo/semantics/openAccess |
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openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Cold Spring Harbor Laboratory |
| publisher.none.fl_str_mv |
Cold Spring Harbor Laboratory |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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