Antimalarial Activity of Aqueous Extracts of Nasturtium (Tropaeolum majus L.) and Benzyl Isothiocyanate

Detalhes bibliográficos
Autor(a) principal: Pintão, Ana Maria
Data de Publicação: 2024
Outros Autores: Santos, Tiago, Nogueira, Fátima
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/168814
Resumo: Funding Information: This research was funded by Funda\u00E7\u00E3o para a Ci\u00EAncia e Tecnologia through projects GHTMUID/04413/2020 and LA-REAL-LA/P/0117/2020. Publisher Copyright: © 2024 by the authors.
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spelling Antimalarial Activity of Aqueous Extracts of Nasturtium (Tropaeolum majus L.) and Benzyl IsothiocyanatePlasmodium falciparumTropaeolum majus Lantimalarialsbenzyl isothiocyanateInfectious DiseasesParasitologyPharmacology, Toxicology and Pharmaceutics(all)Drug DiscoverySDG 3 - Good Health and Well-beingFunding Information: This research was funded by Funda\u00E7\u00E3o para a Ci\u00EAncia e Tecnologia through projects GHTMUID/04413/2020 and LA-REAL-LA/P/0117/2020. Publisher Copyright: © 2024 by the authors.Malaria remains an important and challenging infectious disease, and novel antimalarials are required. Benzyl isothiocyanate (BITC), the main breakdown product of benzyl glucosinolate, is present in all parts of Tropaeolum majus L. ( T. majus) and has antibacterial and antiparasitic activities. To our knowledge, there is no information on the effects of BITC against malaria. The present study evaluates the antimalarial activity of aqueous extracts of BITC and T. majus seeds, leaves, and stems. We used flow cytometry to calculate the growth inhibition (GI) percentage of the extracts and BITC against unsynchronized cultures of the chloroquine-susceptible Plasmodium falciparum 3D7 - GFP strain. Extracts and/or compounds with at least 70% GI were validated by IC50 estimation against P. falciparum 3D7 - GFP and Dd2 (chloroquine-resistant strain) unsynchronized cultures by flow cytometry, and the resistance index (RI) was determined. T. majus aqueous extracts showed some antimalarial activity that was higher in seeds than in leaves or stems. BITC's GI was comparable to chloroquine's. BITC's IC50 was similar in both strains; thus, a cross-resistance absence with aminoquinolines was found (RI < 1). BITC presented features that could open new avenues for malaria drug discovery.Instituto de Higiene e Medicina Tropical (IHMT)Global Health and Tropical Medicine (GHTM)LAQV@REQUIMTERUNPintão, Ana MariaSantos, TiagoNogueira, Fátima2024-06-20T00:38:16Z2024-05-152024-05-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/168814eng1420-3049PURE: 92415069https://doi.org/10.3390/molecules29102316info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-10-07T01:37:39Zoai:run.unl.pt:10362/168814Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-10-07T01:37:39Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Antimalarial Activity of Aqueous Extracts of Nasturtium (Tropaeolum majus L.) and Benzyl Isothiocyanate
title Antimalarial Activity of Aqueous Extracts of Nasturtium (Tropaeolum majus L.) and Benzyl Isothiocyanate
spellingShingle Antimalarial Activity of Aqueous Extracts of Nasturtium (Tropaeolum majus L.) and Benzyl Isothiocyanate
Pintão, Ana Maria
Plasmodium falciparum
Tropaeolum majus L
antimalarials
benzyl isothiocyanate
Infectious Diseases
Parasitology
Pharmacology, Toxicology and Pharmaceutics(all)
Drug Discovery
SDG 3 - Good Health and Well-being
title_short Antimalarial Activity of Aqueous Extracts of Nasturtium (Tropaeolum majus L.) and Benzyl Isothiocyanate
title_full Antimalarial Activity of Aqueous Extracts of Nasturtium (Tropaeolum majus L.) and Benzyl Isothiocyanate
title_fullStr Antimalarial Activity of Aqueous Extracts of Nasturtium (Tropaeolum majus L.) and Benzyl Isothiocyanate
title_full_unstemmed Antimalarial Activity of Aqueous Extracts of Nasturtium (Tropaeolum majus L.) and Benzyl Isothiocyanate
title_sort Antimalarial Activity of Aqueous Extracts of Nasturtium (Tropaeolum majus L.) and Benzyl Isothiocyanate
author Pintão, Ana Maria
author_facet Pintão, Ana Maria
Santos, Tiago
Nogueira, Fátima
author_role author
author2 Santos, Tiago
Nogueira, Fátima
author2_role author
author
dc.contributor.none.fl_str_mv Instituto de Higiene e Medicina Tropical (IHMT)
Global Health and Tropical Medicine (GHTM)
LAQV@REQUIMTE
RUN
dc.contributor.author.fl_str_mv Pintão, Ana Maria
Santos, Tiago
Nogueira, Fátima
dc.subject.por.fl_str_mv Plasmodium falciparum
Tropaeolum majus L
antimalarials
benzyl isothiocyanate
Infectious Diseases
Parasitology
Pharmacology, Toxicology and Pharmaceutics(all)
Drug Discovery
SDG 3 - Good Health and Well-being
topic Plasmodium falciparum
Tropaeolum majus L
antimalarials
benzyl isothiocyanate
Infectious Diseases
Parasitology
Pharmacology, Toxicology and Pharmaceutics(all)
Drug Discovery
SDG 3 - Good Health and Well-being
description Funding Information: This research was funded by Funda\u00E7\u00E3o para a Ci\u00EAncia e Tecnologia through projects GHTMUID/04413/2020 and LA-REAL-LA/P/0117/2020. Publisher Copyright: © 2024 by the authors.
publishDate 2024
dc.date.none.fl_str_mv 2024-06-20T00:38:16Z
2024-05-15
2024-05-15T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/168814
url http://hdl.handle.net/10362/168814
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1420-3049
PURE: 92415069
https://doi.org/10.3390/molecules29102316
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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