How Listeria monocytogenes organizes its surface for virulence

Detalhes bibliográficos
Autor(a) principal: Carvalho, F
Data de Publicação: 2014
Outros Autores: Sousa, S, Cabanes, D
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10216/114512
Resumo: Listeria monocytogenes is a Gram-positive pathogen responsible for the manifestation of human listeriosis, an opportunistic foodborne disease with an associated high mortality rate. The key to the pathogenesis of listeriosis is the capacity of this bacterium to trigger its internalization by non-phagocytic cells and to survive and even replicate within phagocytes. The arsenal of virulence proteins deployed by L. monocytogenes to successfully promote the invasion and infection of host cells has been progressively unveiled over the past decades. A large majority of them is located at the cell envelope, which provides an interface for the establishment of close interactions between these bacterial factors and their host targets. Along the multistep pathways carrying these virulence proteins from the inner side of the cytoplasmic membrane to their cell envelope destination, a multiplicity of auxiliary proteins must act on the immature polypeptides to ensure that they not only maturate into fully functional effectors but also are placed or guided to their correct position in the bacterial surface. As the major scaffold for surface proteins, the cell wall and its metabolism are critical elements in listerial virulence. Conversely, the crucial physical support and protection provided by this structure make it an ideal target for the host immune system. Therefore, mechanisms involving fine modifications of cell envelope components are activated by L. monocytogenes to render it less recognizable by the innate immunity sensors or more resistant to the activity of antimicrobial effectors. This review provides a state-of-the-art compilation of the mechanisms used by L. monocytogenes to organize its surface for virulence, with special focus on those proteins that work "behind the frontline", either supporting virulence effectors or ensuring the survival of the bacterium within its host.
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spelling How Listeria monocytogenes organizes its surface for virulenceBacterial Outer Membrane Proteins/geneticsBacterial Outer Membrane Proteins/metabolismBacterial Secretion SystemsCell Membrane/metabolismCell Wall/metabolismGene Expression Regulation, BacterialHost-Pathogen InteractionsHumansListeria monocytogenes/pathogenicityListeria monocytogenes/physiologyListeriosis/microbiologyProtein TransportVirulence/geneticsListeria monocytogenes is a Gram-positive pathogen responsible for the manifestation of human listeriosis, an opportunistic foodborne disease with an associated high mortality rate. The key to the pathogenesis of listeriosis is the capacity of this bacterium to trigger its internalization by non-phagocytic cells and to survive and even replicate within phagocytes. The arsenal of virulence proteins deployed by L. monocytogenes to successfully promote the invasion and infection of host cells has been progressively unveiled over the past decades. A large majority of them is located at the cell envelope, which provides an interface for the establishment of close interactions between these bacterial factors and their host targets. Along the multistep pathways carrying these virulence proteins from the inner side of the cytoplasmic membrane to their cell envelope destination, a multiplicity of auxiliary proteins must act on the immature polypeptides to ensure that they not only maturate into fully functional effectors but also are placed or guided to their correct position in the bacterial surface. As the major scaffold for surface proteins, the cell wall and its metabolism are critical elements in listerial virulence. Conversely, the crucial physical support and protection provided by this structure make it an ideal target for the host immune system. Therefore, mechanisms involving fine modifications of cell envelope components are activated by L. monocytogenes to render it less recognizable by the innate immunity sensors or more resistant to the activity of antimicrobial effectors. This review provides a state-of-the-art compilation of the mechanisms used by L. monocytogenes to organize its surface for virulence, with special focus on those proteins that work "behind the frontline", either supporting virulence effectors or ensuring the survival of the bacterium within its host.Frontiers Media20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10216/114512eng2235-298810.3389/fcimb.2014.00048Carvalho, FSousa, SCabanes, Dinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T16:14:00Zoai:repositorio-aberto.up.pt:10216/114512Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:39:31.207882Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv How Listeria monocytogenes organizes its surface for virulence
title How Listeria monocytogenes organizes its surface for virulence
spellingShingle How Listeria monocytogenes organizes its surface for virulence
Carvalho, F
Bacterial Outer Membrane Proteins/genetics
Bacterial Outer Membrane Proteins/metabolism
Bacterial Secretion Systems
Cell Membrane/metabolism
Cell Wall/metabolism
Gene Expression Regulation, Bacterial
Host-Pathogen Interactions
Humans
Listeria monocytogenes/pathogenicity
Listeria monocytogenes/physiology
Listeriosis/microbiology
Protein Transport
Virulence/genetics
title_short How Listeria monocytogenes organizes its surface for virulence
title_full How Listeria monocytogenes organizes its surface for virulence
title_fullStr How Listeria monocytogenes organizes its surface for virulence
title_full_unstemmed How Listeria monocytogenes organizes its surface for virulence
title_sort How Listeria monocytogenes organizes its surface for virulence
author Carvalho, F
author_facet Carvalho, F
Sousa, S
Cabanes, D
author_role author
author2 Sousa, S
Cabanes, D
author2_role author
author
dc.contributor.author.fl_str_mv Carvalho, F
Sousa, S
Cabanes, D
dc.subject.por.fl_str_mv Bacterial Outer Membrane Proteins/genetics
Bacterial Outer Membrane Proteins/metabolism
Bacterial Secretion Systems
Cell Membrane/metabolism
Cell Wall/metabolism
Gene Expression Regulation, Bacterial
Host-Pathogen Interactions
Humans
Listeria monocytogenes/pathogenicity
Listeria monocytogenes/physiology
Listeriosis/microbiology
Protein Transport
Virulence/genetics
topic Bacterial Outer Membrane Proteins/genetics
Bacterial Outer Membrane Proteins/metabolism
Bacterial Secretion Systems
Cell Membrane/metabolism
Cell Wall/metabolism
Gene Expression Regulation, Bacterial
Host-Pathogen Interactions
Humans
Listeria monocytogenes/pathogenicity
Listeria monocytogenes/physiology
Listeriosis/microbiology
Protein Transport
Virulence/genetics
description Listeria monocytogenes is a Gram-positive pathogen responsible for the manifestation of human listeriosis, an opportunistic foodborne disease with an associated high mortality rate. The key to the pathogenesis of listeriosis is the capacity of this bacterium to trigger its internalization by non-phagocytic cells and to survive and even replicate within phagocytes. The arsenal of virulence proteins deployed by L. monocytogenes to successfully promote the invasion and infection of host cells has been progressively unveiled over the past decades. A large majority of them is located at the cell envelope, which provides an interface for the establishment of close interactions between these bacterial factors and their host targets. Along the multistep pathways carrying these virulence proteins from the inner side of the cytoplasmic membrane to their cell envelope destination, a multiplicity of auxiliary proteins must act on the immature polypeptides to ensure that they not only maturate into fully functional effectors but also are placed or guided to their correct position in the bacterial surface. As the major scaffold for surface proteins, the cell wall and its metabolism are critical elements in listerial virulence. Conversely, the crucial physical support and protection provided by this structure make it an ideal target for the host immune system. Therefore, mechanisms involving fine modifications of cell envelope components are activated by L. monocytogenes to render it less recognizable by the innate immunity sensors or more resistant to the activity of antimicrobial effectors. This review provides a state-of-the-art compilation of the mechanisms used by L. monocytogenes to organize its surface for virulence, with special focus on those proteins that work "behind the frontline", either supporting virulence effectors or ensuring the survival of the bacterium within its host.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10216/114512
url http://hdl.handle.net/10216/114512
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2235-2988
10.3389/fcimb.2014.00048
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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