Lipids under stress - a lipidomic approach for the study of mood disorders

Detalhes bibliográficos
Autor(a) principal: Miranda, André Miguel Lopes
Data de Publicação: 2015
Outros Autores: Oliveira, Tiago Gil
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/40810
Resumo: The emerging field of lipidomics has identified lipids as key players in disease physiology. Their physicochemical diversity allows precise control of cell structure and signaling events through modulation of membrane prop- erties and trafficking of proteins. As such, lipids are important regulators of brain function and have been implicated in neurodegenerative and mood disorders. Importantly, environmental chronic stress has been associated with anxiety and depression and its exposure in rodents has been extensively used as a model to study these diseases. With the accessibility to modern mass- spectrometry lipidomic platforms, it is now possible to snapshot the extensively interconnected lipid network. Here, we review the fundamentals of lipid biology and outline a framework for the interpretation of lipidomic studies as a new approach to study brain pathophysiology. Thus, lipid profiling provides an exciting avenue for the identification of disease signatures with important implications for diagnosis and treatment of mood disorders.
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spelling Lipids under stress - a lipidomic approach for the study of mood disordersbrainchronic stresslipidlipidomicsmass spectrometrymood disordersCiências Médicas::Ciências da SaúdeScience & TechnologyThe emerging field of lipidomics has identified lipids as key players in disease physiology. Their physicochemical diversity allows precise control of cell structure and signaling events through modulation of membrane prop- erties and trafficking of proteins. As such, lipids are important regulators of brain function and have been implicated in neurodegenerative and mood disorders. Importantly, environmental chronic stress has been associated with anxiety and depression and its exposure in rodents has been extensively used as a model to study these diseases. With the accessibility to modern mass- spectrometry lipidomic platforms, it is now possible to snapshot the extensively interconnected lipid network. Here, we review the fundamentals of lipid biology and outline a framework for the interpretation of lipidomic studies as a new approach to study brain pathophysiology. Thus, lipid profiling provides an exciting avenue for the identification of disease signatures with important implications for diagnosis and treatment of mood disorders.We would like to thank Nuno Sousa for critical reading of the manuscript. André Miranda is funded by Fundação para a Ciência e Tecnologia (PD/BD/105915/2014). Tiago Gil Oliveira is funded by Fundação para a Ciência e Tecnologia (PTDC/ SAU-NMC/118971/2010).WileyUniversidade do MinhoMiranda, André Miguel LopesOliveira, Tiago Gil20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/40810engMiranda, A. M., & Oliveira, T. G. (2015). Lipids under stress - A lipidomic approach for the study of mood disorders. BioEssays, 37(11), 1226-1235. doi: 10.1002/bies.2015000700265-924710.1002/bies.20150007026426989http://onlinelibrary.wiley.com/info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:17:10Zoai:repositorium.sdum.uminho.pt:1822/40810Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:09:44.037794Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Lipids under stress - a lipidomic approach for the study of mood disorders
title Lipids under stress - a lipidomic approach for the study of mood disorders
spellingShingle Lipids under stress - a lipidomic approach for the study of mood disorders
Miranda, André Miguel Lopes
brain
chronic stress
lipid
lipidomics
mass spectrometry
mood disorders
Ciências Médicas::Ciências da Saúde
Science & Technology
title_short Lipids under stress - a lipidomic approach for the study of mood disorders
title_full Lipids under stress - a lipidomic approach for the study of mood disorders
title_fullStr Lipids under stress - a lipidomic approach for the study of mood disorders
title_full_unstemmed Lipids under stress - a lipidomic approach for the study of mood disorders
title_sort Lipids under stress - a lipidomic approach for the study of mood disorders
author Miranda, André Miguel Lopes
author_facet Miranda, André Miguel Lopes
Oliveira, Tiago Gil
author_role author
author2 Oliveira, Tiago Gil
author2_role author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Miranda, André Miguel Lopes
Oliveira, Tiago Gil
dc.subject.por.fl_str_mv brain
chronic stress
lipid
lipidomics
mass spectrometry
mood disorders
Ciências Médicas::Ciências da Saúde
Science & Technology
topic brain
chronic stress
lipid
lipidomics
mass spectrometry
mood disorders
Ciências Médicas::Ciências da Saúde
Science & Technology
description The emerging field of lipidomics has identified lipids as key players in disease physiology. Their physicochemical diversity allows precise control of cell structure and signaling events through modulation of membrane prop- erties and trafficking of proteins. As such, lipids are important regulators of brain function and have been implicated in neurodegenerative and mood disorders. Importantly, environmental chronic stress has been associated with anxiety and depression and its exposure in rodents has been extensively used as a model to study these diseases. With the accessibility to modern mass- spectrometry lipidomic platforms, it is now possible to snapshot the extensively interconnected lipid network. Here, we review the fundamentals of lipid biology and outline a framework for the interpretation of lipidomic studies as a new approach to study brain pathophysiology. Thus, lipid profiling provides an exciting avenue for the identification of disease signatures with important implications for diagnosis and treatment of mood disorders.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/40810
url http://hdl.handle.net/1822/40810
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Miranda, A. M., & Oliveira, T. G. (2015). Lipids under stress - A lipidomic approach for the study of mood disorders. BioEssays, 37(11), 1226-1235. doi: 10.1002/bies.201500070
0265-9247
10.1002/bies.201500070
26426989
http://onlinelibrary.wiley.com/
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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