Development of innovative medical devices by dispersing fatty acid eutectic blend on gauzes using supercritical particle generation processes
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/60771 |
Resumo: | In order to limit bacterial infections during wound treatment, it is interesting to consider the concept of loadingmedical devices with antibacterial agents. With this in mind, an innovative system with thermosensitive prop-erties was produced: loading a commercially available gauze with a fatty acid eutectic blend based on lauric acid(LA) and myristic acid (MA). This eutectic blend presents a melting point near physiological temperature, whichtogether with its antibacterial properties make an appealing alternative in biomedical applications. At roomtemperature, the properties and the efficacy of the eutectic blend loaded onto gauzes are preserved, whereas atphysiological temperature the eutectic blend undergoes a phase change that facilitates its diffusion from thegauze. The loading of the eutectic blend onto gauzes was performed using two different supercriticalfluidtechnologies, namely, particle from gas saturated solutions (PGSS) and a derived version of rapid expansion ofsupercritical solution (D-RESS). The PGSS led to a heterogeneous dispersion of the eutectic blend in the gauze,whereas the D-RESS process led to the formation of a homogeneous dispersion along the surface of the gauze.Additionally, with D-RESS no phase separation of the eutectic blend occurred and the cytotoxicity was greatlyimproved compared with PGSS without compromising the antibacterial properties of the fatty acid eutecticblend. Hence, the present study highlights the potential use of theflexible D-RESS process to load the fatty acideutectic blend with antibacterial properties onto medical devices in a controllable way. Overall, the effectsproduced by the loaded gauzes suggest the enormous potential of the developed technology in health-relatedareas. |
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Development of innovative medical devices by dispersing fatty acid eutectic blend on gauzes using supercritical particle generation processesAntibacterialD-RESSEutectic mixtureFatty acidsPGSSThermosensitive devicesCiências Médicas::Biotecnologia MédicaScience & TechnologyIn order to limit bacterial infections during wound treatment, it is interesting to consider the concept of loadingmedical devices with antibacterial agents. With this in mind, an innovative system with thermosensitive prop-erties was produced: loading a commercially available gauze with a fatty acid eutectic blend based on lauric acid(LA) and myristic acid (MA). This eutectic blend presents a melting point near physiological temperature, whichtogether with its antibacterial properties make an appealing alternative in biomedical applications. At roomtemperature, the properties and the efficacy of the eutectic blend loaded onto gauzes are preserved, whereas atphysiological temperature the eutectic blend undergoes a phase change that facilitates its diffusion from thegauze. The loading of the eutectic blend onto gauzes was performed using two different supercriticalfluidtechnologies, namely, particle from gas saturated solutions (PGSS) and a derived version of rapid expansion ofsupercritical solution (D-RESS). The PGSS led to a heterogeneous dispersion of the eutectic blend in the gauze,whereas the D-RESS process led to the formation of a homogeneous dispersion along the surface of the gauze.Additionally, with D-RESS no phase separation of the eutectic blend occurred and the cytotoxicity was greatlyimproved compared with PGSS without compromising the antibacterial properties of the fatty acid eutecticblend. Hence, the present study highlights the potential use of theflexible D-RESS process to load the fatty acideutectic blend with antibacterial properties onto medical devices in a controllable way. Overall, the effectsproduced by the loaded gauzes suggest the enormous potential of the developed technology in health-relatedareas.Foundation for Science and Technology (FCT, Portugal), through project PTDC/BBB-490 EBB/1676/2014 – Des.Zyme and ERC-2016-CoG 725034 (ERC Consolidator Grant Des.solve). Authors would also like to acknowledge the financial support by the “Institute Carnot Star” (France) for the development of the high-pressure experimental setup. J.M.S. would also like to acknowledge the financial support by the FCT through the post-doctoral grant (reference number SFRH/BPD/116779/2016).ElsevierUniversidade do MinhoSilva, Joana Maria MarquesAkkache, S.Araújo, Ana C.Masmoudi, Y.Reis, R. L.Badens, E.Duarte, Ana Rita C.2019-062019-06-01T00:00:00Z10000-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://hdl.handle.net/1822/60771engSilva J. M., Akkache S., Araujo A., Masmoudi Y., Reis R. L., Badens E., Duarte A. R. C. Development of innovative medical devices by dispersing fatty acid eutectic blend on gauzes using supercritical particle generation processes, Materials Science & Engineering C, Vol. 99, pp. 599-610, doi:10.1016/j.msec.2019.02.012, 20190928-493110.1016/j.msec.2019.02.01230889735https://www.sciencedirect.com/science/article/pii/S0928493118321295info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:53:05Zoai:repositorium.sdum.uminho.pt:1822/60771Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:52:23.487971Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Development of innovative medical devices by dispersing fatty acid eutectic blend on gauzes using supercritical particle generation processes |
title |
Development of innovative medical devices by dispersing fatty acid eutectic blend on gauzes using supercritical particle generation processes |
spellingShingle |
Development of innovative medical devices by dispersing fatty acid eutectic blend on gauzes using supercritical particle generation processes Silva, Joana Maria Marques Antibacterial D-RESS Eutectic mixture Fatty acids PGSS Thermosensitive devices Ciências Médicas::Biotecnologia Médica Science & Technology |
title_short |
Development of innovative medical devices by dispersing fatty acid eutectic blend on gauzes using supercritical particle generation processes |
title_full |
Development of innovative medical devices by dispersing fatty acid eutectic blend on gauzes using supercritical particle generation processes |
title_fullStr |
Development of innovative medical devices by dispersing fatty acid eutectic blend on gauzes using supercritical particle generation processes |
title_full_unstemmed |
Development of innovative medical devices by dispersing fatty acid eutectic blend on gauzes using supercritical particle generation processes |
title_sort |
Development of innovative medical devices by dispersing fatty acid eutectic blend on gauzes using supercritical particle generation processes |
author |
Silva, Joana Maria Marques |
author_facet |
Silva, Joana Maria Marques Akkache, S. Araújo, Ana C. Masmoudi, Y. Reis, R. L. Badens, E. Duarte, Ana Rita C. |
author_role |
author |
author2 |
Akkache, S. Araújo, Ana C. Masmoudi, Y. Reis, R. L. Badens, E. Duarte, Ana Rita C. |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Silva, Joana Maria Marques Akkache, S. Araújo, Ana C. Masmoudi, Y. Reis, R. L. Badens, E. Duarte, Ana Rita C. |
dc.subject.por.fl_str_mv |
Antibacterial D-RESS Eutectic mixture Fatty acids PGSS Thermosensitive devices Ciências Médicas::Biotecnologia Médica Science & Technology |
topic |
Antibacterial D-RESS Eutectic mixture Fatty acids PGSS Thermosensitive devices Ciências Médicas::Biotecnologia Médica Science & Technology |
description |
In order to limit bacterial infections during wound treatment, it is interesting to consider the concept of loadingmedical devices with antibacterial agents. With this in mind, an innovative system with thermosensitive prop-erties was produced: loading a commercially available gauze with a fatty acid eutectic blend based on lauric acid(LA) and myristic acid (MA). This eutectic blend presents a melting point near physiological temperature, whichtogether with its antibacterial properties make an appealing alternative in biomedical applications. At roomtemperature, the properties and the efficacy of the eutectic blend loaded onto gauzes are preserved, whereas atphysiological temperature the eutectic blend undergoes a phase change that facilitates its diffusion from thegauze. The loading of the eutectic blend onto gauzes was performed using two different supercriticalfluidtechnologies, namely, particle from gas saturated solutions (PGSS) and a derived version of rapid expansion ofsupercritical solution (D-RESS). The PGSS led to a heterogeneous dispersion of the eutectic blend in the gauze,whereas the D-RESS process led to the formation of a homogeneous dispersion along the surface of the gauze.Additionally, with D-RESS no phase separation of the eutectic blend occurred and the cytotoxicity was greatlyimproved compared with PGSS without compromising the antibacterial properties of the fatty acid eutecticblend. Hence, the present study highlights the potential use of theflexible D-RESS process to load the fatty acideutectic blend with antibacterial properties onto medical devices in a controllable way. Overall, the effectsproduced by the loaded gauzes suggest the enormous potential of the developed technology in health-relatedareas. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
10000-01-01T00:00:00Z 2019-06 2019-06-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/60771 |
url |
http://hdl.handle.net/1822/60771 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Silva J. M., Akkache S., Araujo A., Masmoudi Y., Reis R. L., Badens E., Duarte A. R. C. Development of innovative medical devices by dispersing fatty acid eutectic blend on gauzes using supercritical particle generation processes, Materials Science & Engineering C, Vol. 99, pp. 599-610, doi:10.1016/j.msec.2019.02.012, 2019 0928-4931 10.1016/j.msec.2019.02.012 30889735 https://www.sciencedirect.com/science/article/pii/S0928493118321295 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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