A systematic review with network meta-analysis of the available biologic therapies for psoriatic disease domains

Detalhes bibliográficos
Autor(a) principal: Torres, Tiago
Data de Publicação: 2021
Outros Autores: Barcelos, Anabela, Filipe, Paulo, Fonseca, João Eurico
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/50277
Resumo: Copyright © 2021 Torres, Barcelos, Filipe and Fonseca. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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spelling A systematic review with network meta-analysis of the available biologic therapies for psoriatic disease domainsPsoriasisPsoriatic arthritisPsoriatic diseaseBiologic therapySystematic reviewNetwork meta-analysisCopyright © 2021 Torres, Barcelos, Filipe and Fonseca. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Introduction: Several new treatments have been developed for psoriatic disease, an inflammatory condition that involves skin and joints. Notwithstanding, few studies have made direct comparisons between treatments and therefore it is difficult to select the ideal treatment for an individual patient. The aim of this systematic review with network meta-analysis (NMA) was to analyze available and approved biologic therapies for each domain of psoriatic disease: skin, peripheral arthritis, axial arthritis, enthesitis, dactylitis, and nail involvement. Methods: Data from randomized clinical trials (RCTs) were included. A systematic review was performed using the MEDLINE database (July 2020) using PICO criteria. Bayesian NMA was conducted to compare the clinical efficacy of biological therapy in terms of the American College of Rheumatology criteria (ACR, 24 weeks) and Psoriasis Area and Severity Index (PASI, 10-16 weeks). Results: Fifty-four RCTs were included in the systematic review. Due to the design of the RCTs, namely, outcomes and time points, network meta-analysis was performed for skin and peripheral arthritis domains. For the skin domain, 30 studies reporting PASI100 were included. The peripheral arthritis domain was analyzed through ACR70 in 12 studies. From the therapies approved for both domains, secukinumab and ixekizumab were the ones with the highest probability of reaching the proposed outcomes. There is a lack of outcome uniformization in the dactylitis, enthesitis, and nail domains, and therefore, an objective comparison of the studies was not feasible. Nevertheless, secukinumab was the treatment with the best compromise between the number of studies in each domain and the results obtained in the different outcomes. Conclusion: Secukinumab and ixekizumab were the treatments with the highest probability of reaching both PASI100 and ACR70 outcomes. Due to the lack of a standard evaluation of outcomes of the other psoriatic disease domains, a network meta-analysis for all the domains was not possible to perform.FrontiersRepositório da Universidade de LisboaTorres, TiagoBarcelos, AnabelaFilipe, PauloFonseca, João Eurico2021-12-03T16:58:46Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/50277engFrontiers in medicine, 7, 61816310.3389/fmed.2020.6181632296-858Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:54:23Zoai:repositorio.ul.pt:10451/50277Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:01:46.356756Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv A systematic review with network meta-analysis of the available biologic therapies for psoriatic disease domains
title A systematic review with network meta-analysis of the available biologic therapies for psoriatic disease domains
spellingShingle A systematic review with network meta-analysis of the available biologic therapies for psoriatic disease domains
Torres, Tiago
Psoriasis
Psoriatic arthritis
Psoriatic disease
Biologic therapy
Systematic review
Network meta-analysis
title_short A systematic review with network meta-analysis of the available biologic therapies for psoriatic disease domains
title_full A systematic review with network meta-analysis of the available biologic therapies for psoriatic disease domains
title_fullStr A systematic review with network meta-analysis of the available biologic therapies for psoriatic disease domains
title_full_unstemmed A systematic review with network meta-analysis of the available biologic therapies for psoriatic disease domains
title_sort A systematic review with network meta-analysis of the available biologic therapies for psoriatic disease domains
author Torres, Tiago
author_facet Torres, Tiago
Barcelos, Anabela
Filipe, Paulo
Fonseca, João Eurico
author_role author
author2 Barcelos, Anabela
Filipe, Paulo
Fonseca, João Eurico
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Torres, Tiago
Barcelos, Anabela
Filipe, Paulo
Fonseca, João Eurico
dc.subject.por.fl_str_mv Psoriasis
Psoriatic arthritis
Psoriatic disease
Biologic therapy
Systematic review
Network meta-analysis
topic Psoriasis
Psoriatic arthritis
Psoriatic disease
Biologic therapy
Systematic review
Network meta-analysis
description Copyright © 2021 Torres, Barcelos, Filipe and Fonseca. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
publishDate 2021
dc.date.none.fl_str_mv 2021-12-03T16:58:46Z
2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/50277
url http://hdl.handle.net/10451/50277
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Frontiers in medicine, 7, 618163
10.3389/fmed.2020.618163
2296-858X
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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