Insights into corrosion behaviour of uncoated Mg alloys for biomedical applications in different aqueous media
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10773/40438 |
Resumo: | MgCa and MgGd series of alloys are often reported as promising candidates for biomedical applications. In the present study, cytotoxicity and corrosion behavior of Mg1Ca and Mg10Gd alloys in different electrolytes (NaCl, PBS, MEM) have been investigated in order to make a direct comparison and understand the mechanisms behind their performance. Potentiodynamic polarization and electrochemical impedance spectroscopy (EIS) were employed to analyze corrosion processes depending on media composition, whereas X-Ray diffraction (XRD) and scanning electron microscopy (SEM) were used to evaluate crystalline structure, phase composition and surface morphology of the corroded substrates after immersion in the different electrolytes. Moreover, cytotoxicity of the Mg alloys was assessed using the WST-1 reduction and lactate dehydrogenase (LDH) release assays in L929 mouse fibroblasts. The electrochemical results showed that Mg1Ca has a lower degradation rate when compared to Mg10Gd, due to the lower microgalvanic effects and the presence of Ca as an alloying element. Furthermore, the corrosion activity is reduced in MEM, for both alloys, when compared to NaCl and PBS. The cytotoxicity assays revealed that Mg10Gd was cytotoxic in all the conditions tested, while the toxicity of Mg1Ca was low. Overall, these findings show that Mg1Ca alloy presents a higher corrosion resistance and biocompatibility and is a promising material to be used in biomedical implants |
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Insights into corrosion behaviour of uncoated Mg alloys for biomedical applications in different aqueous mediaBiomedical applicationsCorrosion protectionIn vitro cytotoxicityMagnesium alloysMgCa and MgGd series of alloys are often reported as promising candidates for biomedical applications. In the present study, cytotoxicity and corrosion behavior of Mg1Ca and Mg10Gd alloys in different electrolytes (NaCl, PBS, MEM) have been investigated in order to make a direct comparison and understand the mechanisms behind their performance. Potentiodynamic polarization and electrochemical impedance spectroscopy (EIS) were employed to analyze corrosion processes depending on media composition, whereas X-Ray diffraction (XRD) and scanning electron microscopy (SEM) were used to evaluate crystalline structure, phase composition and surface morphology of the corroded substrates after immersion in the different electrolytes. Moreover, cytotoxicity of the Mg alloys was assessed using the WST-1 reduction and lactate dehydrogenase (LDH) release assays in L929 mouse fibroblasts. The electrochemical results showed that Mg1Ca has a lower degradation rate when compared to Mg10Gd, due to the lower microgalvanic effects and the presence of Ca as an alloying element. Furthermore, the corrosion activity is reduced in MEM, for both alloys, when compared to NaCl and PBS. The cytotoxicity assays revealed that Mg10Gd was cytotoxic in all the conditions tested, while the toxicity of Mg1Ca was low. Overall, these findings show that Mg1Ca alloy presents a higher corrosion resistance and biocompatibility and is a promising material to be used in biomedical implantsElsevier2024-01-31T15:42:04Z2021-07-01T00:00:00Z2021-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/40438eng2238-785410.1016/j.jmrt.2021.05.090Neves, C. S.Sousa, IsabelFreitas, Maria AdrianaMoreira, L.Costa, C.Teixeira, J. P.Fraga, S.Pinto, E.Almeida, A.Scharnagl, N.Zheludkevich, M. L.Ferreira, MarioTedim, J.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T12:19:25Zoai:ria.ua.pt:10773/40438Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:10:30.812661Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Insights into corrosion behaviour of uncoated Mg alloys for biomedical applications in different aqueous media |
title |
Insights into corrosion behaviour of uncoated Mg alloys for biomedical applications in different aqueous media |
spellingShingle |
Insights into corrosion behaviour of uncoated Mg alloys for biomedical applications in different aqueous media Neves, C. S. Biomedical applications Corrosion protection In vitro cytotoxicity Magnesium alloys |
title_short |
Insights into corrosion behaviour of uncoated Mg alloys for biomedical applications in different aqueous media |
title_full |
Insights into corrosion behaviour of uncoated Mg alloys for biomedical applications in different aqueous media |
title_fullStr |
Insights into corrosion behaviour of uncoated Mg alloys for biomedical applications in different aqueous media |
title_full_unstemmed |
Insights into corrosion behaviour of uncoated Mg alloys for biomedical applications in different aqueous media |
title_sort |
Insights into corrosion behaviour of uncoated Mg alloys for biomedical applications in different aqueous media |
author |
Neves, C. S. |
author_facet |
Neves, C. S. Sousa, Isabel Freitas, Maria Adriana Moreira, L. Costa, C. Teixeira, J. P. Fraga, S. Pinto, E. Almeida, A. Scharnagl, N. Zheludkevich, M. L. Ferreira, Mario Tedim, J. |
author_role |
author |
author2 |
Sousa, Isabel Freitas, Maria Adriana Moreira, L. Costa, C. Teixeira, J. P. Fraga, S. Pinto, E. Almeida, A. Scharnagl, N. Zheludkevich, M. L. Ferreira, Mario Tedim, J. |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Neves, C. S. Sousa, Isabel Freitas, Maria Adriana Moreira, L. Costa, C. Teixeira, J. P. Fraga, S. Pinto, E. Almeida, A. Scharnagl, N. Zheludkevich, M. L. Ferreira, Mario Tedim, J. |
dc.subject.por.fl_str_mv |
Biomedical applications Corrosion protection In vitro cytotoxicity Magnesium alloys |
topic |
Biomedical applications Corrosion protection In vitro cytotoxicity Magnesium alloys |
description |
MgCa and MgGd series of alloys are often reported as promising candidates for biomedical applications. In the present study, cytotoxicity and corrosion behavior of Mg1Ca and Mg10Gd alloys in different electrolytes (NaCl, PBS, MEM) have been investigated in order to make a direct comparison and understand the mechanisms behind their performance. Potentiodynamic polarization and electrochemical impedance spectroscopy (EIS) were employed to analyze corrosion processes depending on media composition, whereas X-Ray diffraction (XRD) and scanning electron microscopy (SEM) were used to evaluate crystalline structure, phase composition and surface morphology of the corroded substrates after immersion in the different electrolytes. Moreover, cytotoxicity of the Mg alloys was assessed using the WST-1 reduction and lactate dehydrogenase (LDH) release assays in L929 mouse fibroblasts. The electrochemical results showed that Mg1Ca has a lower degradation rate when compared to Mg10Gd, due to the lower microgalvanic effects and the presence of Ca as an alloying element. Furthermore, the corrosion activity is reduced in MEM, for both alloys, when compared to NaCl and PBS. The cytotoxicity assays revealed that Mg10Gd was cytotoxic in all the conditions tested, while the toxicity of Mg1Ca was low. Overall, these findings show that Mg1Ca alloy presents a higher corrosion resistance and biocompatibility and is a promising material to be used in biomedical implants |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-07-01T00:00:00Z 2021-07-01 2024-01-31T15:42:04Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10773/40438 |
url |
http://hdl.handle.net/10773/40438 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2238-7854 10.1016/j.jmrt.2021.05.090 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799137755551236096 |