State-of-art on gel technologies for transdermal delivery of bacitracin

Detalhes bibliográficos
Autor(a) principal: Antunes, Sara Margarida Gomes
Data de Publicação: 2016
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/36382
Resumo: Dissertação de mestrado em Tecnologias do Medicamento, apresentada à Faculdade de Farmácia da Universidade de Coimbra
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spelling State-of-art on gel technologies for transdermal delivery of bacitracinBacitracinaAdministração cutâneaSistemas de libertação de medicamentosTecnologia farmacêuticaGéisHidrogéisEmulsõesDissertação de mestrado em Tecnologias do Medicamento, apresentada à Faculdade de Farmácia da Universidade de CoimbraGels have consistently been studied for their role in topical and transdermal drug delivery systems as a non-invasive technique, for pharmaceutical and cosmetics application. These formulations are semi-solid three-dimensional structures, porous, with unique characteristics, such as rigidity and elasticity at the same time. Because of their high aqueous phase content, gels permit a greater dissolution of drugs through the skin and enhance skin hydration by retaining a significant amount of transepidermal water, in contrast to creams and ointments. Conventionally, gels are differentiated into two different types according to the nature of their liquid phase: hydrogels, which contain a polar solvent (water) and organogels, which contain an organic/non-polar solvent, as external phase. Hydrogels consist of polymeric materials that exhibit the ability to swell and retain a large amount of water or other biofluids in its structures. Despite its great affinity for water, they only possess a swelling behavior without dissolving in water. This proves its high flexibility, similar to natural tissue. Organogels consist of a network of self-assembled molecules which forms a thermally reversible gel upon cooling, immobilizing a non-aqueous liquid. They are mainly composed by lipids (organic phase), so they easily interact with the lipid skin surface and enhance the drug permeation through the skin. The most widely used lipids are based in edible oils due to their high biocompatibility, such as soybean oil, sunflower oil, sesame seed oil or olive oil. Organogels form viscoelastic structures through non-covalent associations with gelling agents in low concentrations. The commonly used organogelators include sorbitan monostearate or sorbitan monopalmitate. These superstructures, often long fibers or needle-shaped structures, which entangle or form pseudocrystalline regions, immobilizing the liquid largely by surface tension and forming a gel of variable consistency. Lecithin organogels are a special type of organogels that do not require addition of any additional surfactant or penetration enhancer, as lecithin serves both the purposes. Recent studies have reported other types of gels for dermal drug application, such as proniosomal gels, emulgels, bigels and aerogels, combining features of conventional hydrogels and organogels. In conclusion, further studies in gel technologies are essentials to overcome the drawbacks of each gel system and for developing cost effective delivery systems for transdermal applications.2016-09info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesishttp://hdl.handle.net/10316/36382http://hdl.handle.net/10316/36382engAntunes, Sara Margarida Gomesinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-01-20T17:48:42Zoai:estudogeral.uc.pt:10316/36382Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:47:38.534934Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv State-of-art on gel technologies for transdermal delivery of bacitracin
title State-of-art on gel technologies for transdermal delivery of bacitracin
spellingShingle State-of-art on gel technologies for transdermal delivery of bacitracin
Antunes, Sara Margarida Gomes
Bacitracina
Administração cutânea
Sistemas de libertação de medicamentos
Tecnologia farmacêutica
Géis
Hidrogéis
Emulsões
title_short State-of-art on gel technologies for transdermal delivery of bacitracin
title_full State-of-art on gel technologies for transdermal delivery of bacitracin
title_fullStr State-of-art on gel technologies for transdermal delivery of bacitracin
title_full_unstemmed State-of-art on gel technologies for transdermal delivery of bacitracin
title_sort State-of-art on gel technologies for transdermal delivery of bacitracin
author Antunes, Sara Margarida Gomes
author_facet Antunes, Sara Margarida Gomes
author_role author
dc.contributor.author.fl_str_mv Antunes, Sara Margarida Gomes
dc.subject.por.fl_str_mv Bacitracina
Administração cutânea
Sistemas de libertação de medicamentos
Tecnologia farmacêutica
Géis
Hidrogéis
Emulsões
topic Bacitracina
Administração cutânea
Sistemas de libertação de medicamentos
Tecnologia farmacêutica
Géis
Hidrogéis
Emulsões
description Dissertação de mestrado em Tecnologias do Medicamento, apresentada à Faculdade de Farmácia da Universidade de Coimbra
publishDate 2016
dc.date.none.fl_str_mv 2016-09
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/36382
http://hdl.handle.net/10316/36382
url http://hdl.handle.net/10316/36382
dc.language.iso.fl_str_mv eng
language eng
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eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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