Influence of arthritis on descending modulation of nociception from the paraventricular nucleus of the hypothalamus
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/7914 |
Resumo: | We studied the influence of arthritis on descending modulation of nociception from the hypothalamic paraventricular nucleus (PVN) in the rat. Spinal nociception was assessed by the heat-evoked limb withdrawal in awake animals while neuronal responses were recorded in a potential brainstem relay, the rostroventromedial medulla (RVM), under pentobarbitone anesthesia. Following injection into the PVN, glutamate attenuated and lidocaine enhanced nociceptive spinal reflex responses in arthritic and control animals. In controls, PVN-induced antinociception was reversed by spinal administration of a 5-HT1A receptor or an α2-adrenoceptor antagonist but not by an opioid receptor antagonist. In arthritic animals, PVN-induced antinociception was not reversed by a 5-HT1A receptor antagonist, while the roles of α2-adrenoceptors or opioid receptors could not be assessed due to significant actions of antagonists alone. The spontaneous activity of presumably pronociceptive ON-cells of the RVM and that of antinociceptive OFF-cells was increased in arthritis. Lidocaine in the PVN increased ON-cell firing in control animals and decreased OFF-cell firing in arthritic animals, while glutamate failed to affect activity of RVM cells. The results indicate that the PVN influences phasic and tonic descending antinociception in arthritic as well as control conditions, and the RVM may contribute to the relay of this influence. In arthritis, the neurochemistry of descending antinociception differs at least partly from that in controls. Arthritis has a dual influence on the PVN-induced drive of relay cells in the RVM which reduces the arthritis-induced net change in the descending antinociceptive influence from the PVN. |
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Influence of arthritis on descending modulation of nociception from the paraventricular nucleus of the hypothalamusArthritic painDescending modulationHypothalamusSpinal nociceptionScience & TechnologyWe studied the influence of arthritis on descending modulation of nociception from the hypothalamic paraventricular nucleus (PVN) in the rat. Spinal nociception was assessed by the heat-evoked limb withdrawal in awake animals while neuronal responses were recorded in a potential brainstem relay, the rostroventromedial medulla (RVM), under pentobarbitone anesthesia. Following injection into the PVN, glutamate attenuated and lidocaine enhanced nociceptive spinal reflex responses in arthritic and control animals. In controls, PVN-induced antinociception was reversed by spinal administration of a 5-HT1A receptor or an α2-adrenoceptor antagonist but not by an opioid receptor antagonist. In arthritic animals, PVN-induced antinociception was not reversed by a 5-HT1A receptor antagonist, while the roles of α2-adrenoceptors or opioid receptors could not be assessed due to significant actions of antagonists alone. The spontaneous activity of presumably pronociceptive ON-cells of the RVM and that of antinociceptive OFF-cells was increased in arthritis. Lidocaine in the PVN increased ON-cell firing in control animals and decreased OFF-cell firing in arthritic animals, while glutamate failed to affect activity of RVM cells. The results indicate that the PVN influences phasic and tonic descending antinociception in arthritic as well as control conditions, and the RVM may contribute to the relay of this influence. In arthritis, the neurochemistry of descending antinociception differs at least partly from that in controls. Arthritis has a dual influence on the PVN-induced drive of relay cells in the RVM which reduces the arthritis-induced net change in the descending antinociceptive influence from the PVN.Grünenthal FoundationCalouste Gulbenkian FoundationCentre for International Mobility (CIMO)Sigrid Jusélius FoundationAcademy of FinlandElsevierUniversidade do MinhoRibeiro, Filipa PintoAnsah, Osei B.Almeida, ArmandoPertovaara, Antti2008-03-042008-03-04T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/7914eng"Brain Research". ISSN 0006-8993. 1197 (Mar. 2008) 63-75.0006-899310.1016/j.brainres.2007.12.03818242585http://www.sciencedirect.com/science/journal/00068993info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:06:40Zoai:repositorium.sdum.uminho.pt:1822/7914Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:57:26.553300Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Influence of arthritis on descending modulation of nociception from the paraventricular nucleus of the hypothalamus |
title |
Influence of arthritis on descending modulation of nociception from the paraventricular nucleus of the hypothalamus |
spellingShingle |
Influence of arthritis on descending modulation of nociception from the paraventricular nucleus of the hypothalamus Ribeiro, Filipa Pinto Arthritic pain Descending modulation Hypothalamus Spinal nociception Science & Technology |
title_short |
Influence of arthritis on descending modulation of nociception from the paraventricular nucleus of the hypothalamus |
title_full |
Influence of arthritis on descending modulation of nociception from the paraventricular nucleus of the hypothalamus |
title_fullStr |
Influence of arthritis on descending modulation of nociception from the paraventricular nucleus of the hypothalamus |
title_full_unstemmed |
Influence of arthritis on descending modulation of nociception from the paraventricular nucleus of the hypothalamus |
title_sort |
Influence of arthritis on descending modulation of nociception from the paraventricular nucleus of the hypothalamus |
author |
Ribeiro, Filipa Pinto |
author_facet |
Ribeiro, Filipa Pinto Ansah, Osei B. Almeida, Armando Pertovaara, Antti |
author_role |
author |
author2 |
Ansah, Osei B. Almeida, Armando Pertovaara, Antti |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Ribeiro, Filipa Pinto Ansah, Osei B. Almeida, Armando Pertovaara, Antti |
dc.subject.por.fl_str_mv |
Arthritic pain Descending modulation Hypothalamus Spinal nociception Science & Technology |
topic |
Arthritic pain Descending modulation Hypothalamus Spinal nociception Science & Technology |
description |
We studied the influence of arthritis on descending modulation of nociception from the hypothalamic paraventricular nucleus (PVN) in the rat. Spinal nociception was assessed by the heat-evoked limb withdrawal in awake animals while neuronal responses were recorded in a potential brainstem relay, the rostroventromedial medulla (RVM), under pentobarbitone anesthesia. Following injection into the PVN, glutamate attenuated and lidocaine enhanced nociceptive spinal reflex responses in arthritic and control animals. In controls, PVN-induced antinociception was reversed by spinal administration of a 5-HT1A receptor or an α2-adrenoceptor antagonist but not by an opioid receptor antagonist. In arthritic animals, PVN-induced antinociception was not reversed by a 5-HT1A receptor antagonist, while the roles of α2-adrenoceptors or opioid receptors could not be assessed due to significant actions of antagonists alone. The spontaneous activity of presumably pronociceptive ON-cells of the RVM and that of antinociceptive OFF-cells was increased in arthritis. Lidocaine in the PVN increased ON-cell firing in control animals and decreased OFF-cell firing in arthritic animals, while glutamate failed to affect activity of RVM cells. The results indicate that the PVN influences phasic and tonic descending antinociception in arthritic as well as control conditions, and the RVM may contribute to the relay of this influence. In arthritis, the neurochemistry of descending antinociception differs at least partly from that in controls. Arthritis has a dual influence on the PVN-induced drive of relay cells in the RVM which reduces the arthritis-induced net change in the descending antinociceptive influence from the PVN. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-03-04 2008-03-04T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/7914 |
url |
http://hdl.handle.net/1822/7914 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
"Brain Research". ISSN 0006-8993. 1197 (Mar. 2008) 63-75. 0006-8993 10.1016/j.brainres.2007.12.038 18242585 http://www.sciencedirect.com/science/journal/00068993 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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