Programming effects of antenatal corticosteroids exposure in male sexual behavior

Detalhes bibliográficos
Autor(a) principal: Oliveira, Mário
Data de Publicação: 2011
Outros Autores: Leão, Pedro, Rodrigues, Ana João, Pêgo, José M., Cerqueira, João, Sousa, Nuno
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/18737
Resumo: The authors would like to thank the Clinical Laboratory of Hospital de Braga for technical support.
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spelling Programming effects of antenatal corticosteroids exposure in male sexual behaviorAntenatal corticotherapyCorticosteroidsDopamineNeurodevelopmentSexual behaviorCentral Neurochemichal CorrelatesScience & TechnologyThe authors would like to thank the Clinical Laboratory of Hospital de Braga for technical support.Introduction: Brain regions implicated in sexual behavior begin to differentiate in the last trimester of gestation. Antenatal therapy with corticosteroids is often used in clinical practice during this period to accelerate lung maturation in pre-term risk pregnancies. Clinical and animal studies highlighted major behavioral impairments induced later in life by these treatments, especially when synthetic corticosteroids are used. Aim: To evaluate the implications of acute prenatal treatment with natural versus synthetic corticosteroids on adult male rat sexual behavior and its neurochemical correlates. Methods: Twelve pregnant Wistar rats were injected with dexamethasone (DEX-1mg/kg), corticosterone (CORT-25mg/kg) or saline on late gestation (pregnancy days 18 and 19). Following this brief exposure to corticosteroids, we assessed the sexual behavior of the adult male progeny and subsequently correlated these behaviors with the levels of cathecolamines and mRNA of dopamine and androgen receptors (AR) in brain regions relevant for sexual behavior. Main Outcome Measures: Sexual behavior of adult male offspring was assessed by exposure to receptive females. This was correlated with serum testosterone levels and levels of cathecolamines (determined by HPLC) and dopamine and androgen receptors mRNA expression (real-time PCR) in brain regions implicated in sexual behavior. Results: Prenatal DEX exposure resulted in a decreased number and increased latency time to mounts and intromissions in adulthood. These findings correlated with decreased levels of serum testosterone and increased hypothalamic expression of AR mRNA. DEX animals also displayed lower dopamine levels and higher dopamine receptor mRNA expression both in hypothalamus and nucleus accumbens (NAcc). The milder phenotype of CORT animals was correlated only with decreased dopamine levels in NAcc. Conclusion: Antenatal corticotherapy programs adult male sexual behavior through changes in specific neuronal and endocrine mediators. Importantly, equipotent doses of corticosterone trigger less detrimental consequences than dexamethasone, emphasizing the differential impact of activation of the different corticosteroid receptors.Supported by a grant from the Institute for the Study of Affective NeuroscienceInternational Society for Sexual MedicineUniversidade do MinhoOliveira, MárioLeão, PedroRodrigues, Ana JoãoPêgo, José M.Cerqueira, JoãoSousa, Nuno2011-072011-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/18737eng1743-609510.1111/j.1743-6109.2010.02170.x21235719info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:14:01Zoai:repositorium.sdum.uminho.pt:1822/18737Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:06:14.800325Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Programming effects of antenatal corticosteroids exposure in male sexual behavior
title Programming effects of antenatal corticosteroids exposure in male sexual behavior
spellingShingle Programming effects of antenatal corticosteroids exposure in male sexual behavior
Oliveira, Mário
Antenatal corticotherapy
Corticosteroids
Dopamine
Neurodevelopment
Sexual behavior
Central Neurochemichal Correlates
Science & Technology
title_short Programming effects of antenatal corticosteroids exposure in male sexual behavior
title_full Programming effects of antenatal corticosteroids exposure in male sexual behavior
title_fullStr Programming effects of antenatal corticosteroids exposure in male sexual behavior
title_full_unstemmed Programming effects of antenatal corticosteroids exposure in male sexual behavior
title_sort Programming effects of antenatal corticosteroids exposure in male sexual behavior
author Oliveira, Mário
author_facet Oliveira, Mário
Leão, Pedro
Rodrigues, Ana João
Pêgo, José M.
Cerqueira, João
Sousa, Nuno
author_role author
author2 Leão, Pedro
Rodrigues, Ana João
Pêgo, José M.
Cerqueira, João
Sousa, Nuno
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Oliveira, Mário
Leão, Pedro
Rodrigues, Ana João
Pêgo, José M.
Cerqueira, João
Sousa, Nuno
dc.subject.por.fl_str_mv Antenatal corticotherapy
Corticosteroids
Dopamine
Neurodevelopment
Sexual behavior
Central Neurochemichal Correlates
Science & Technology
topic Antenatal corticotherapy
Corticosteroids
Dopamine
Neurodevelopment
Sexual behavior
Central Neurochemichal Correlates
Science & Technology
description The authors would like to thank the Clinical Laboratory of Hospital de Braga for technical support.
publishDate 2011
dc.date.none.fl_str_mv 2011-07
2011-07-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/18737
url http://hdl.handle.net/1822/18737
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1743-6095
10.1111/j.1743-6109.2010.02170.x
21235719
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv International Society for Sexual Medicine
publisher.none.fl_str_mv International Society for Sexual Medicine
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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