Pulmonary oxidative stress and apoptosis in mice chronically exposed to hydrothermal volcanic emissions
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.3/6193 |
Resumo: | Recent studies have shown that exposure to hydrothermal emissions has a negative impact on the respiratory system. Still, volcanogenic air pollution studies are still outnumbered when compared to anthropogenic studies which can result in an unknown risk to the human populations living near volcanically active areas. This study was carried out in São Miguel Island, with noneruptive volcanically active environments, such as the Furnas volcano caldera. Its noneruptive volcanism presents itself as hydrothermal emissions, mainly by the release of nearly 1000 T d-1 of CO₂ along with H₂S, and the radioactive gas radon; metals [e.g., mercury (Hg), cadmium (Cd), copper (Cu), and zinc (Zn)] and particulate matter are also released in a daily basis. We test the hypothesis whether chronic exposure to hydrothermal emissions causes pulmonary oxidative stress, using Mus musculus as a surrogate species. Mus musculus was live-captured in two villages with hydrothermal emissions and one village without any type of volcanic activity. The level of pulmonary oxidative stress was immunohistochemically assessed by using an OxyIHCTM Oxidative stress detection kit, and the detection of terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end-labeling (TUNEL) was used to evaluate apoptosis in lung tissues. Mice chronically exposed to hydrothermal emissions presented increased levels of oxidative stress and amount of apoptotic cells. We demonstrate, for the first time, the high oxidative stress potential in the lungs of mice chronically exposed to hydrothermal emissions. This study highlights the usefulness of M. musculus as a bioindicator species and enforces the necessity of regularly biomonitor the inhabitants of hydrothermal areas to prevent respiratory pathologies. |
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Pulmonary oxidative stress and apoptosis in mice chronically exposed to hydrothermal volcanic emissionsAir PollutionNoneruptive VolcanismOxidative StressTUNEL AssayMus musculusRecent studies have shown that exposure to hydrothermal emissions has a negative impact on the respiratory system. Still, volcanogenic air pollution studies are still outnumbered when compared to anthropogenic studies which can result in an unknown risk to the human populations living near volcanically active areas. This study was carried out in São Miguel Island, with noneruptive volcanically active environments, such as the Furnas volcano caldera. Its noneruptive volcanism presents itself as hydrothermal emissions, mainly by the release of nearly 1000 T d-1 of CO₂ along with H₂S, and the radioactive gas radon; metals [e.g., mercury (Hg), cadmium (Cd), copper (Cu), and zinc (Zn)] and particulate matter are also released in a daily basis. We test the hypothesis whether chronic exposure to hydrothermal emissions causes pulmonary oxidative stress, using Mus musculus as a surrogate species. Mus musculus was live-captured in two villages with hydrothermal emissions and one village without any type of volcanic activity. The level of pulmonary oxidative stress was immunohistochemically assessed by using an OxyIHCTM Oxidative stress detection kit, and the detection of terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end-labeling (TUNEL) was used to evaluate apoptosis in lung tissues. Mice chronically exposed to hydrothermal emissions presented increased levels of oxidative stress and amount of apoptotic cells. We demonstrate, for the first time, the high oxidative stress potential in the lungs of mice chronically exposed to hydrothermal emissions. This study highlights the usefulness of M. musculus as a bioindicator species and enforces the necessity of regularly biomonitor the inhabitants of hydrothermal areas to prevent respiratory pathologies.Ricardo Camarinho is currently supported by a PhD fellowship grant (M3.1.a/F/048/2015) from Fundo Regional da Ciencia (Regional Government of the Azores).Springer Science and Business Media LLCRepositório da Universidade dos AçoresCamarinho, RicardoGarcia, PatríciaChoi, HyunokRodrigues, Armindo2022-02-14T10:55:28Z2021-072021-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.3/6193engCamarinho, R., Garcia, P.V., Choi, H. & Rodrigues, A.S. (2021). Pulmonary oxidative stress and apoptosis in mice chronically exposed to hydrothermal volcanic emissions. “Environmental Science & Pollution Research”, 28(27), 35709-35716. DOI: 10.1007/s11356-021-13043-00944-134410.1007/s11356-021-13043-01614-749933675493000625738500007metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-12-20T14:34:38Zoai:repositorio.uac.pt:10400.3/6193Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:28:21.870404Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Pulmonary oxidative stress and apoptosis in mice chronically exposed to hydrothermal volcanic emissions |
title |
Pulmonary oxidative stress and apoptosis in mice chronically exposed to hydrothermal volcanic emissions |
spellingShingle |
Pulmonary oxidative stress and apoptosis in mice chronically exposed to hydrothermal volcanic emissions Camarinho, Ricardo Air Pollution Noneruptive Volcanism Oxidative Stress TUNEL Assay Mus musculus |
title_short |
Pulmonary oxidative stress and apoptosis in mice chronically exposed to hydrothermal volcanic emissions |
title_full |
Pulmonary oxidative stress and apoptosis in mice chronically exposed to hydrothermal volcanic emissions |
title_fullStr |
Pulmonary oxidative stress and apoptosis in mice chronically exposed to hydrothermal volcanic emissions |
title_full_unstemmed |
Pulmonary oxidative stress and apoptosis in mice chronically exposed to hydrothermal volcanic emissions |
title_sort |
Pulmonary oxidative stress and apoptosis in mice chronically exposed to hydrothermal volcanic emissions |
author |
Camarinho, Ricardo |
author_facet |
Camarinho, Ricardo Garcia, Patrícia Choi, Hyunok Rodrigues, Armindo |
author_role |
author |
author2 |
Garcia, Patrícia Choi, Hyunok Rodrigues, Armindo |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade dos Açores |
dc.contributor.author.fl_str_mv |
Camarinho, Ricardo Garcia, Patrícia Choi, Hyunok Rodrigues, Armindo |
dc.subject.por.fl_str_mv |
Air Pollution Noneruptive Volcanism Oxidative Stress TUNEL Assay Mus musculus |
topic |
Air Pollution Noneruptive Volcanism Oxidative Stress TUNEL Assay Mus musculus |
description |
Recent studies have shown that exposure to hydrothermal emissions has a negative impact on the respiratory system. Still, volcanogenic air pollution studies are still outnumbered when compared to anthropogenic studies which can result in an unknown risk to the human populations living near volcanically active areas. This study was carried out in São Miguel Island, with noneruptive volcanically active environments, such as the Furnas volcano caldera. Its noneruptive volcanism presents itself as hydrothermal emissions, mainly by the release of nearly 1000 T d-1 of CO₂ along with H₂S, and the radioactive gas radon; metals [e.g., mercury (Hg), cadmium (Cd), copper (Cu), and zinc (Zn)] and particulate matter are also released in a daily basis. We test the hypothesis whether chronic exposure to hydrothermal emissions causes pulmonary oxidative stress, using Mus musculus as a surrogate species. Mus musculus was live-captured in two villages with hydrothermal emissions and one village without any type of volcanic activity. The level of pulmonary oxidative stress was immunohistochemically assessed by using an OxyIHCTM Oxidative stress detection kit, and the detection of terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end-labeling (TUNEL) was used to evaluate apoptosis in lung tissues. Mice chronically exposed to hydrothermal emissions presented increased levels of oxidative stress and amount of apoptotic cells. We demonstrate, for the first time, the high oxidative stress potential in the lungs of mice chronically exposed to hydrothermal emissions. This study highlights the usefulness of M. musculus as a bioindicator species and enforces the necessity of regularly biomonitor the inhabitants of hydrothermal areas to prevent respiratory pathologies. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-07 2021-07-01T00:00:00Z 2022-02-14T10:55:28Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.3/6193 |
url |
http://hdl.handle.net/10400.3/6193 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Camarinho, R., Garcia, P.V., Choi, H. & Rodrigues, A.S. (2021). Pulmonary oxidative stress and apoptosis in mice chronically exposed to hydrothermal volcanic emissions. “Environmental Science & Pollution Research”, 28(27), 35709-35716. DOI: 10.1007/s11356-021-13043-0 0944-1344 10.1007/s11356-021-13043-0 1614-7499 33675493 000625738500007 |
dc.rights.driver.fl_str_mv |
metadata only access info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
metadata only access |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Springer Science and Business Media LLC |
publisher.none.fl_str_mv |
Springer Science and Business Media LLC |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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