Hexahydro-Pyrrolo[1',2',5':3,4,5]Thiazolo[3,4-c]Oxazol-1-ones: New Chiral Tricyclic L-Cysteine and D-Penicillamine Derivatives.

• Autor(a) principal: Melo, Teresa M. V. D. Pinho e
• Data de Publicação: 2006
• Outros Autores: Lopes, Susana M. M., Gonsalves, Antonio M. d'A Rocha, Kaczor, Agnieszka, Fausto, Rui, Paixão, José A., Beja, Ana Matos, Silva, Manuela Ramos
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10316/17937; https://doi.org/10.2174/157017806779116996.

A simple and efficient approach to the synthesis of the new chiral hexahydropyrrolo [1',2',5':3,4,5]thiazolo[3,4-c]oxazol-1-one ring system is reported. Infrared spectroscopy, quantum-chemical calculations and X-ray analysis allowed the stereochemistry assignment of (2aS,4aR,6aR)-2a,3,4,4a,6,6ahexahydropyrrolo-[ 1',2',5':3,4,5]thiazolo[3,4-c]oxazol-1-one. [ABSTRACT FROM AUTHOR]. Copyright of Letters in Organic Chemistry is the property of Bentham Science Publishers Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.).