Hydrogel-Based Drug Delivery Nanosystems for the Treatment of Brain Tumors
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/107658 https://doi.org/10.3390/gels4030062 |
Resumo: | Chemotherapy is commonly associated with limited effectiveness and unwanted side effects in normal cells and tissues, due to the lack of specificity of therapeutic agents to cancer cells when systemically administered. In brain tumors, the existence of both physiological barriers that protect tumor cells and complex resistance mechanisms to anticancer drugs are additional obstacles that hamper a successful course of chemotherapy, thus resulting in high treatment failure rates. Several potential surrogate therapies have been developed so far. In this context, hydrogel-based systems incorporating nanostructured drug delivery systems (DDS) and hydrogel nanoparticles, also denoted nanogels, have arisen as a more effective and safer strategy than conventional chemotherapeutic regimens. The former, as a local delivery approach, have the ability to confine the release of anticancer drugs near tumor cells over a long period of time, without compromising healthy cells and tissues. Yet, the latter may be systemically administered and provide both loading and targeting properties in their own framework, thus identifying and efficiently killing tumor cells. Overall, this review focuses on the application of hydrogel matrices containing nanostructured DDS and hydrogel nanoparticles as potential and promising strategies for the treatment and diagnosis of glioblastoma and other types of brain cancer. Some aspects pertaining to computational studies are finally addressed. |
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Hydrogel-Based Drug Delivery Nanosystems for the Treatment of Brain Tumorshydrogelnanostructured drug delivery systemhydrogel nanoparticlesglioblastomadrug deliverylocal treatmentChemotherapy is commonly associated with limited effectiveness and unwanted side effects in normal cells and tissues, due to the lack of specificity of therapeutic agents to cancer cells when systemically administered. In brain tumors, the existence of both physiological barriers that protect tumor cells and complex resistance mechanisms to anticancer drugs are additional obstacles that hamper a successful course of chemotherapy, thus resulting in high treatment failure rates. Several potential surrogate therapies have been developed so far. In this context, hydrogel-based systems incorporating nanostructured drug delivery systems (DDS) and hydrogel nanoparticles, also denoted nanogels, have arisen as a more effective and safer strategy than conventional chemotherapeutic regimens. The former, as a local delivery approach, have the ability to confine the release of anticancer drugs near tumor cells over a long period of time, without compromising healthy cells and tissues. Yet, the latter may be systemically administered and provide both loading and targeting properties in their own framework, thus identifying and efficiently killing tumor cells. Overall, this review focuses on the application of hydrogel matrices containing nanostructured DDS and hydrogel nanoparticles as potential and promising strategies for the treatment and diagnosis of glioblastoma and other types of brain cancer. Some aspects pertaining to computational studies are finally addressed.MDPI2018-07-19info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/107658http://hdl.handle.net/10316/107658https://doi.org/10.3390/gels4030062eng2310-2861Basso, JoãoMiranda, AnaNunes, SandraCova, TâniaSousa, JoãoVitorino, CarlaPais, Albertoinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-26T09:44:45Zoai:estudogeral.uc.pt:10316/107658Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:23:59.181003Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Hydrogel-Based Drug Delivery Nanosystems for the Treatment of Brain Tumors |
title |
Hydrogel-Based Drug Delivery Nanosystems for the Treatment of Brain Tumors |
spellingShingle |
Hydrogel-Based Drug Delivery Nanosystems for the Treatment of Brain Tumors Basso, João hydrogel nanostructured drug delivery system hydrogel nanoparticles glioblastoma drug delivery local treatment |
title_short |
Hydrogel-Based Drug Delivery Nanosystems for the Treatment of Brain Tumors |
title_full |
Hydrogel-Based Drug Delivery Nanosystems for the Treatment of Brain Tumors |
title_fullStr |
Hydrogel-Based Drug Delivery Nanosystems for the Treatment of Brain Tumors |
title_full_unstemmed |
Hydrogel-Based Drug Delivery Nanosystems for the Treatment of Brain Tumors |
title_sort |
Hydrogel-Based Drug Delivery Nanosystems for the Treatment of Brain Tumors |
author |
Basso, João |
author_facet |
Basso, João Miranda, Ana Nunes, Sandra Cova, Tânia Sousa, João Vitorino, Carla Pais, Alberto |
author_role |
author |
author2 |
Miranda, Ana Nunes, Sandra Cova, Tânia Sousa, João Vitorino, Carla Pais, Alberto |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Basso, João Miranda, Ana Nunes, Sandra Cova, Tânia Sousa, João Vitorino, Carla Pais, Alberto |
dc.subject.por.fl_str_mv |
hydrogel nanostructured drug delivery system hydrogel nanoparticles glioblastoma drug delivery local treatment |
topic |
hydrogel nanostructured drug delivery system hydrogel nanoparticles glioblastoma drug delivery local treatment |
description |
Chemotherapy is commonly associated with limited effectiveness and unwanted side effects in normal cells and tissues, due to the lack of specificity of therapeutic agents to cancer cells when systemically administered. In brain tumors, the existence of both physiological barriers that protect tumor cells and complex resistance mechanisms to anticancer drugs are additional obstacles that hamper a successful course of chemotherapy, thus resulting in high treatment failure rates. Several potential surrogate therapies have been developed so far. In this context, hydrogel-based systems incorporating nanostructured drug delivery systems (DDS) and hydrogel nanoparticles, also denoted nanogels, have arisen as a more effective and safer strategy than conventional chemotherapeutic regimens. The former, as a local delivery approach, have the ability to confine the release of anticancer drugs near tumor cells over a long period of time, without compromising healthy cells and tissues. Yet, the latter may be systemically administered and provide both loading and targeting properties in their own framework, thus identifying and efficiently killing tumor cells. Overall, this review focuses on the application of hydrogel matrices containing nanostructured DDS and hydrogel nanoparticles as potential and promising strategies for the treatment and diagnosis of glioblastoma and other types of brain cancer. Some aspects pertaining to computational studies are finally addressed. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-07-19 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/107658 http://hdl.handle.net/10316/107658 https://doi.org/10.3390/gels4030062 |
url |
http://hdl.handle.net/10316/107658 https://doi.org/10.3390/gels4030062 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2310-2861 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799134125816283136 |