Optimization of data recording during Isolated Limb Perfusion Technique

• Autor(a) principal: Monteiro, Ana Jorge Branco
• Data de Publicação: 2020
• Tipo de documento: Dissertação
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10400.22/16730
• topic: Isolated Limb Perfusion; Cancer; Nuclear Medicine; Radioisotope; Melphalan; TNF- α

Cancer is a disease in which the cells of our organism, due to mutations in their DNA, divide without control and acquire malignant properties and, during this process of uncontrolled division, invade other tissues and don’t die. Cancer cells have the ability to spread through the body using the circulatory and lymphatic systems, giving rise to metastases. With regard to cutaneous neoplasms, the therapy chosen for surgically dispersed and unresectable metastases involved amputation of the sick limb, however, many complications and short time intervals between treatment and the appearance of new lesions were associated. In 1957, an innovative technique emerges and proves to be extremely effective and avoids limb amputation: Isolated Limb Perfusion performed with Melphalan and TNF-α. The main objective of this procedure is to isolate the limb affected by the disease from the systemic circulation so that it is possible to administer very high doses of chemotherapy without any collateral damage. In this sense, it is necessary to have a control of blood leaks from the limb to the systemic circulation, in order to ensure that no other organ or tissue is compromised. The Portuguese Institute of Oncology (IPO) of Porto is one of the worldwide institutions that practice this type of surgical interventions, reporting an annual increase in the number of occurrences year after year. Consequently, this progressive increase and coupled with the fact that this leak control is impractical and time-consuming, led this institution to join Instituto Superior de Engenharia do Porto (ISEP) to develop an application that, in combination with an extracorporeal counter equipment called Neoprobe Gamma Detector System is able to record the values obtained automatically and allow monitoring possible leaks.