Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel Disease

Detalhes bibliográficos
Autor(a) principal: Costa Pereira, Cristiana
Data de Publicação: 2017
Outros Autores: Durães, Cecília, Coelho, Rosa, Grácio, Daniela, Silva, Marco, Peixoto, Armando, Lago, Paula, Pereira, Márcia, Catarino, Telmo, Pinho, Salomé, Teixeira, João Paulo, Macedo, Guilherme, Annese, Vito, Magro, Fernando
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/5429
Resumo: Inflammation is the driving force in inflammatory bowel disease (IBD) and its link to oxidative stress and carcinogenesis has long been accepted. The antioxidant system of the intestinal mucosa in IBD is compromised resulting in increased oxidative injury. This defective antioxidant system may be the result of genetic variants in antioxidant genes, which can represent susceptibility factors for IBD, namely Crohn's disease (CD) and ulcerative colitis (UC). Single nucleotide polymorphisms (SNPs) in the antioxidant genes SOD2 (rs4880) and GPX1 (rs1050450) were genotyped in a Portuguese population comprising 436 Crohn's disease and 367 ulcerative colitis patients, and 434 healthy controls. We found that the AA genotype in GPX1 is associated with ulcerative colitis (OR = 1.93, adjusted P-value = 0.037). Moreover, we found nominal significant associations between SOD2 and Crohn's disease susceptibility and disease subphenotypes but these did not withstand the correction for multiple testing. These findings indicate a possible link between disease phenotypes and antioxidant genes. These results suggest a potential role for antioxidant genes in IBD pathogenesis and should be considered in future association studies.
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spelling Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel DiseaseAdultAgedColitis, UlcerativeCrohn DiseaseFemaleGenetic Predisposition to DiseaseGenotypeGlutathione PeroxidaseHumansInflammatory Bowel DiseasesMaleMiddle AgedPolymorphism, Single NucleotideSuperoxide DismutaseGenotoxicidade AmbientalInflammation is the driving force in inflammatory bowel disease (IBD) and its link to oxidative stress and carcinogenesis has long been accepted. The antioxidant system of the intestinal mucosa in IBD is compromised resulting in increased oxidative injury. This defective antioxidant system may be the result of genetic variants in antioxidant genes, which can represent susceptibility factors for IBD, namely Crohn's disease (CD) and ulcerative colitis (UC). Single nucleotide polymorphisms (SNPs) in the antioxidant genes SOD2 (rs4880) and GPX1 (rs1050450) were genotyped in a Portuguese population comprising 436 Crohn's disease and 367 ulcerative colitis patients, and 434 healthy controls. We found that the AA genotype in GPX1 is associated with ulcerative colitis (OR = 1.93, adjusted P-value = 0.037). Moreover, we found nominal significant associations between SOD2 and Crohn's disease susceptibility and disease subphenotypes but these did not withstand the correction for multiple testing. These findings indicate a possible link between disease phenotypes and antioxidant genes. These results suggest a potential role for antioxidant genes in IBD pathogenesis and should be considered in future association studies.Public Library of ScienceRepositório Científico do Instituto Nacional de SaúdeCosta Pereira, CristianaDurães, CecíliaCoelho, RosaGrácio, DanielaSilva, MarcoPeixoto, ArmandoLago, PaulaPereira, MárciaCatarino, TelmoPinho, SaloméTeixeira, João PauloMacedo, GuilhermeAnnese, VitoMagro, Fernando2018-03-22T15:36:44Z2017-01-042017-01-04T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/5429engPLoS One. 2017 Jan 4;12(1):e0169102. doi: 10.1371/journal.pone.0169102. eCollection 20171932-620310.1371/journal.pone.0169102info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:40:51Zoai:repositorio.insa.pt:10400.18/5429Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:40:07.294087Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel Disease
title Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel Disease
spellingShingle Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel Disease
Costa Pereira, Cristiana
Adult
Aged
Colitis, Ulcerative
Crohn Disease
Female
Genetic Predisposition to Disease
Genotype
Glutathione Peroxidase
Humans
Inflammatory Bowel Diseases
Male
Middle Aged
Polymorphism, Single Nucleotide
Superoxide Dismutase
Genotoxicidade Ambiental
title_short Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel Disease
title_full Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel Disease
title_fullStr Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel Disease
title_full_unstemmed Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel Disease
title_sort Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel Disease
author Costa Pereira, Cristiana
author_facet Costa Pereira, Cristiana
Durães, Cecília
Coelho, Rosa
Grácio, Daniela
Silva, Marco
Peixoto, Armando
Lago, Paula
Pereira, Márcia
Catarino, Telmo
Pinho, Salomé
Teixeira, João Paulo
Macedo, Guilherme
Annese, Vito
Magro, Fernando
author_role author
author2 Durães, Cecília
Coelho, Rosa
Grácio, Daniela
Silva, Marco
Peixoto, Armando
Lago, Paula
Pereira, Márcia
Catarino, Telmo
Pinho, Salomé
Teixeira, João Paulo
Macedo, Guilherme
Annese, Vito
Magro, Fernando
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Costa Pereira, Cristiana
Durães, Cecília
Coelho, Rosa
Grácio, Daniela
Silva, Marco
Peixoto, Armando
Lago, Paula
Pereira, Márcia
Catarino, Telmo
Pinho, Salomé
Teixeira, João Paulo
Macedo, Guilherme
Annese, Vito
Magro, Fernando
dc.subject.por.fl_str_mv Adult
Aged
Colitis, Ulcerative
Crohn Disease
Female
Genetic Predisposition to Disease
Genotype
Glutathione Peroxidase
Humans
Inflammatory Bowel Diseases
Male
Middle Aged
Polymorphism, Single Nucleotide
Superoxide Dismutase
Genotoxicidade Ambiental
topic Adult
Aged
Colitis, Ulcerative
Crohn Disease
Female
Genetic Predisposition to Disease
Genotype
Glutathione Peroxidase
Humans
Inflammatory Bowel Diseases
Male
Middle Aged
Polymorphism, Single Nucleotide
Superoxide Dismutase
Genotoxicidade Ambiental
description Inflammation is the driving force in inflammatory bowel disease (IBD) and its link to oxidative stress and carcinogenesis has long been accepted. The antioxidant system of the intestinal mucosa in IBD is compromised resulting in increased oxidative injury. This defective antioxidant system may be the result of genetic variants in antioxidant genes, which can represent susceptibility factors for IBD, namely Crohn's disease (CD) and ulcerative colitis (UC). Single nucleotide polymorphisms (SNPs) in the antioxidant genes SOD2 (rs4880) and GPX1 (rs1050450) were genotyped in a Portuguese population comprising 436 Crohn's disease and 367 ulcerative colitis patients, and 434 healthy controls. We found that the AA genotype in GPX1 is associated with ulcerative colitis (OR = 1.93, adjusted P-value = 0.037). Moreover, we found nominal significant associations between SOD2 and Crohn's disease susceptibility and disease subphenotypes but these did not withstand the correction for multiple testing. These findings indicate a possible link between disease phenotypes and antioxidant genes. These results suggest a potential role for antioxidant genes in IBD pathogenesis and should be considered in future association studies.
publishDate 2017
dc.date.none.fl_str_mv 2017-01-04
2017-01-04T00:00:00Z
2018-03-22T15:36:44Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/5429
url http://hdl.handle.net/10400.18/5429
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv PLoS One. 2017 Jan 4;12(1):e0169102. doi: 10.1371/journal.pone.0169102. eCollection 2017
1932-6203
10.1371/journal.pone.0169102
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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