Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel Disease
Autor(a) principal: | |
---|---|
Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.18/5429 |
Resumo: | Inflammation is the driving force in inflammatory bowel disease (IBD) and its link to oxidative stress and carcinogenesis has long been accepted. The antioxidant system of the intestinal mucosa in IBD is compromised resulting in increased oxidative injury. This defective antioxidant system may be the result of genetic variants in antioxidant genes, which can represent susceptibility factors for IBD, namely Crohn's disease (CD) and ulcerative colitis (UC). Single nucleotide polymorphisms (SNPs) in the antioxidant genes SOD2 (rs4880) and GPX1 (rs1050450) were genotyped in a Portuguese population comprising 436 Crohn's disease and 367 ulcerative colitis patients, and 434 healthy controls. We found that the AA genotype in GPX1 is associated with ulcerative colitis (OR = 1.93, adjusted P-value = 0.037). Moreover, we found nominal significant associations between SOD2 and Crohn's disease susceptibility and disease subphenotypes but these did not withstand the correction for multiple testing. These findings indicate a possible link between disease phenotypes and antioxidant genes. These results suggest a potential role for antioxidant genes in IBD pathogenesis and should be considered in future association studies. |
id |
RCAP_b7d0f542ec2f88064b9d838d7f8f475a |
---|---|
oai_identifier_str |
oai:repositorio.insa.pt:10400.18/5429 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel DiseaseAdultAgedColitis, UlcerativeCrohn DiseaseFemaleGenetic Predisposition to DiseaseGenotypeGlutathione PeroxidaseHumansInflammatory Bowel DiseasesMaleMiddle AgedPolymorphism, Single NucleotideSuperoxide DismutaseGenotoxicidade AmbientalInflammation is the driving force in inflammatory bowel disease (IBD) and its link to oxidative stress and carcinogenesis has long been accepted. The antioxidant system of the intestinal mucosa in IBD is compromised resulting in increased oxidative injury. This defective antioxidant system may be the result of genetic variants in antioxidant genes, which can represent susceptibility factors for IBD, namely Crohn's disease (CD) and ulcerative colitis (UC). Single nucleotide polymorphisms (SNPs) in the antioxidant genes SOD2 (rs4880) and GPX1 (rs1050450) were genotyped in a Portuguese population comprising 436 Crohn's disease and 367 ulcerative colitis patients, and 434 healthy controls. We found that the AA genotype in GPX1 is associated with ulcerative colitis (OR = 1.93, adjusted P-value = 0.037). Moreover, we found nominal significant associations between SOD2 and Crohn's disease susceptibility and disease subphenotypes but these did not withstand the correction for multiple testing. These findings indicate a possible link between disease phenotypes and antioxidant genes. These results suggest a potential role for antioxidant genes in IBD pathogenesis and should be considered in future association studies.Public Library of ScienceRepositório Científico do Instituto Nacional de SaúdeCosta Pereira, CristianaDurães, CecíliaCoelho, RosaGrácio, DanielaSilva, MarcoPeixoto, ArmandoLago, PaulaPereira, MárciaCatarino, TelmoPinho, SaloméTeixeira, João PauloMacedo, GuilhermeAnnese, VitoMagro, Fernando2018-03-22T15:36:44Z2017-01-042017-01-04T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/5429engPLoS One. 2017 Jan 4;12(1):e0169102. doi: 10.1371/journal.pone.0169102. eCollection 20171932-620310.1371/journal.pone.0169102info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:40:51Zoai:repositorio.insa.pt:10400.18/5429Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:40:07.294087Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel Disease |
title |
Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel Disease |
spellingShingle |
Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel Disease Costa Pereira, Cristiana Adult Aged Colitis, Ulcerative Crohn Disease Female Genetic Predisposition to Disease Genotype Glutathione Peroxidase Humans Inflammatory Bowel Diseases Male Middle Aged Polymorphism, Single Nucleotide Superoxide Dismutase Genotoxicidade Ambiental |
title_short |
Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel Disease |
title_full |
Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel Disease |
title_fullStr |
Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel Disease |
title_full_unstemmed |
Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel Disease |
title_sort |
Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel Disease |
author |
Costa Pereira, Cristiana |
author_facet |
Costa Pereira, Cristiana Durães, Cecília Coelho, Rosa Grácio, Daniela Silva, Marco Peixoto, Armando Lago, Paula Pereira, Márcia Catarino, Telmo Pinho, Salomé Teixeira, João Paulo Macedo, Guilherme Annese, Vito Magro, Fernando |
author_role |
author |
author2 |
Durães, Cecília Coelho, Rosa Grácio, Daniela Silva, Marco Peixoto, Armando Lago, Paula Pereira, Márcia Catarino, Telmo Pinho, Salomé Teixeira, João Paulo Macedo, Guilherme Annese, Vito Magro, Fernando |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
dc.contributor.author.fl_str_mv |
Costa Pereira, Cristiana Durães, Cecília Coelho, Rosa Grácio, Daniela Silva, Marco Peixoto, Armando Lago, Paula Pereira, Márcia Catarino, Telmo Pinho, Salomé Teixeira, João Paulo Macedo, Guilherme Annese, Vito Magro, Fernando |
dc.subject.por.fl_str_mv |
Adult Aged Colitis, Ulcerative Crohn Disease Female Genetic Predisposition to Disease Genotype Glutathione Peroxidase Humans Inflammatory Bowel Diseases Male Middle Aged Polymorphism, Single Nucleotide Superoxide Dismutase Genotoxicidade Ambiental |
topic |
Adult Aged Colitis, Ulcerative Crohn Disease Female Genetic Predisposition to Disease Genotype Glutathione Peroxidase Humans Inflammatory Bowel Diseases Male Middle Aged Polymorphism, Single Nucleotide Superoxide Dismutase Genotoxicidade Ambiental |
description |
Inflammation is the driving force in inflammatory bowel disease (IBD) and its link to oxidative stress and carcinogenesis has long been accepted. The antioxidant system of the intestinal mucosa in IBD is compromised resulting in increased oxidative injury. This defective antioxidant system may be the result of genetic variants in antioxidant genes, which can represent susceptibility factors for IBD, namely Crohn's disease (CD) and ulcerative colitis (UC). Single nucleotide polymorphisms (SNPs) in the antioxidant genes SOD2 (rs4880) and GPX1 (rs1050450) were genotyped in a Portuguese population comprising 436 Crohn's disease and 367 ulcerative colitis patients, and 434 healthy controls. We found that the AA genotype in GPX1 is associated with ulcerative colitis (OR = 1.93, adjusted P-value = 0.037). Moreover, we found nominal significant associations between SOD2 and Crohn's disease susceptibility and disease subphenotypes but these did not withstand the correction for multiple testing. These findings indicate a possible link between disease phenotypes and antioxidant genes. These results suggest a potential role for antioxidant genes in IBD pathogenesis and should be considered in future association studies. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-01-04 2017-01-04T00:00:00Z 2018-03-22T15:36:44Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/5429 |
url |
http://hdl.handle.net/10400.18/5429 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
PLoS One. 2017 Jan 4;12(1):e0169102. doi: 10.1371/journal.pone.0169102. eCollection 2017 1932-6203 10.1371/journal.pone.0169102 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Public Library of Science |
publisher.none.fl_str_mv |
Public Library of Science |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1817552125856579584 |