Unknown Primary Merkel Cell Carcinoma With Cutaneous Spread

Detalhes bibliográficos
Autor(a) principal: Barreira, JV
Data de Publicação: 2019
Outros Autores: Valejo Coelho, M, Ribeiro, C, Semedo, M
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.17/3600
Resumo: The authors present the case of a woman in the seventh decade of life with medical history of: left nephrectomy for renal tuberculosis and non-Hodgkin's lymphoma treated with chemotherapy (QT) and radiotherapy. She presented with a 2-month history of non-tender, left inguinal lymph node enlargement. Positron Emission Tomography (PET)-CT -scanshowed hypermetabolic inguinal and retroperitoneal lymphadenopathies, no primary tumour. On the second dermatological examination a pink, 2 cm plaque on the anterior left knee was noted. The histopathological analysis revealed Merkel cell carcinoma. The patient underwent two lines of systemic QT, with life-threatening toxicities limiting treatment. Followed overwhelming disease progression with lymphoedema and numerous skin metastases in the left lower limb. The patient received palliative care until death. The rare incidence of such neoplasia and its uncommon clinical presentation justifies reporting this case and highlights the importance of multidisciplinary teams in the management of cancer patients.
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spelling Unknown Primary Merkel Cell Carcinoma With Cutaneous SpreadAgedAntineoplastic Combined Chemotherapy ProtocolsCarcinoma, Merkel CellCombined Modality TherapyDisease ProgressionFatal OutcomeFemaleHumansKneeNeoplasms, Unknown PrimaryPalliative CarePositron-Emission TomographyRadiotherapy, AdjuvantSkin NeoplasmsHSAC ONCCHLC DERThe authors present the case of a woman in the seventh decade of life with medical history of: left nephrectomy for renal tuberculosis and non-Hodgkin's lymphoma treated with chemotherapy (QT) and radiotherapy. She presented with a 2-month history of non-tender, left inguinal lymph node enlargement. Positron Emission Tomography (PET)-CT -scanshowed hypermetabolic inguinal and retroperitoneal lymphadenopathies, no primary tumour. On the second dermatological examination a pink, 2 cm plaque on the anterior left knee was noted. The histopathological analysis revealed Merkel cell carcinoma. The patient underwent two lines of systemic QT, with life-threatening toxicities limiting treatment. Followed overwhelming disease progression with lymphoedema and numerous skin metastases in the left lower limb. The patient received palliative care until death. The rare incidence of such neoplasia and its uncommon clinical presentation justifies reporting this case and highlights the importance of multidisciplinary teams in the management of cancer patients.BMJ Publishing GroupRepositório do Centro Hospitalar Universitário de Lisboa Central, EPEBarreira, JVValejo Coelho, MRibeiro, CSemedo, M2021-03-17T16:02:31Z2019-02-212019-02-21T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/3600engBMJ Case Rep. 2019 Feb 21;12(2):e224834.10.1136/bcr-2018-224834info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:43:45Zoai:repositorio.chlc.min-saude.pt:10400.17/3600Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:20:54.399594Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Unknown Primary Merkel Cell Carcinoma With Cutaneous Spread
title Unknown Primary Merkel Cell Carcinoma With Cutaneous Spread
spellingShingle Unknown Primary Merkel Cell Carcinoma With Cutaneous Spread
Barreira, JV
Aged
Antineoplastic Combined Chemotherapy Protocols
Carcinoma, Merkel Cell
Combined Modality Therapy
Disease Progression
Fatal Outcome
Female
Humans
Knee
Neoplasms, Unknown Primary
Palliative Care
Positron-Emission Tomography
Radiotherapy, Adjuvant
Skin Neoplasms
HSAC ONC
CHLC DER
title_short Unknown Primary Merkel Cell Carcinoma With Cutaneous Spread
title_full Unknown Primary Merkel Cell Carcinoma With Cutaneous Spread
title_fullStr Unknown Primary Merkel Cell Carcinoma With Cutaneous Spread
title_full_unstemmed Unknown Primary Merkel Cell Carcinoma With Cutaneous Spread
title_sort Unknown Primary Merkel Cell Carcinoma With Cutaneous Spread
author Barreira, JV
author_facet Barreira, JV
Valejo Coelho, M
Ribeiro, C
Semedo, M
author_role author
author2 Valejo Coelho, M
Ribeiro, C
Semedo, M
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE
dc.contributor.author.fl_str_mv Barreira, JV
Valejo Coelho, M
Ribeiro, C
Semedo, M
dc.subject.por.fl_str_mv Aged
Antineoplastic Combined Chemotherapy Protocols
Carcinoma, Merkel Cell
Combined Modality Therapy
Disease Progression
Fatal Outcome
Female
Humans
Knee
Neoplasms, Unknown Primary
Palliative Care
Positron-Emission Tomography
Radiotherapy, Adjuvant
Skin Neoplasms
HSAC ONC
CHLC DER
topic Aged
Antineoplastic Combined Chemotherapy Protocols
Carcinoma, Merkel Cell
Combined Modality Therapy
Disease Progression
Fatal Outcome
Female
Humans
Knee
Neoplasms, Unknown Primary
Palliative Care
Positron-Emission Tomography
Radiotherapy, Adjuvant
Skin Neoplasms
HSAC ONC
CHLC DER
description The authors present the case of a woman in the seventh decade of life with medical history of: left nephrectomy for renal tuberculosis and non-Hodgkin's lymphoma treated with chemotherapy (QT) and radiotherapy. She presented with a 2-month history of non-tender, left inguinal lymph node enlargement. Positron Emission Tomography (PET)-CT -scanshowed hypermetabolic inguinal and retroperitoneal lymphadenopathies, no primary tumour. On the second dermatological examination a pink, 2 cm plaque on the anterior left knee was noted. The histopathological analysis revealed Merkel cell carcinoma. The patient underwent two lines of systemic QT, with life-threatening toxicities limiting treatment. Followed overwhelming disease progression with lymphoedema and numerous skin metastases in the left lower limb. The patient received palliative care until death. The rare incidence of such neoplasia and its uncommon clinical presentation justifies reporting this case and highlights the importance of multidisciplinary teams in the management of cancer patients.
publishDate 2019
dc.date.none.fl_str_mv 2019-02-21
2019-02-21T00:00:00Z
2021-03-17T16:02:31Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.17/3600
url http://hdl.handle.net/10400.17/3600
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv BMJ Case Rep. 2019 Feb 21;12(2):e224834.
10.1136/bcr-2018-224834
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMJ Publishing Group
publisher.none.fl_str_mv BMJ Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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