Quinoxaline, its derivatives and applications: A state of the art review

Detalhes bibliográficos
Autor(a) principal: Almeida, Joana
Data de Publicação: 2015
Outros Autores: Pessoa, Ana M., Cordeiro, M. Natália D. S., Fernandes, Rúben, Prudêncio, Cristina, Noronha, João Paulo, Vieira, Mónica
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.22/18919
Resumo: Quinoxaline derivatives are an important class of heterocycle compounds, where N replaces some carbon atoms in the ring of naphthalene. Its molecular formula is C8H6N2, formed by the fusion of two aromatic rings, benzene and pyrazine. It is rare in natural state, but their synthesis is easy to perform. In this review the State of the Art will be presented, which includes a summary of the progress made over the past years in the knowledge of the structure and mechanism of the quinoxaline and quinoxaline derivatives, associated medical and biomedical value as well as industrial value. Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.
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spelling Quinoxaline, its derivatives and applications: A state of the art reviewQuinoxalineQuinoxaline derivativesBiological activityTherapeutic applicationBiomedical applicationsQuinoxaline derivatives are an important class of heterocycle compounds, where N replaces some carbon atoms in the ring of naphthalene. Its molecular formula is C8H6N2, formed by the fusion of two aromatic rings, benzene and pyrazine. It is rare in natural state, but their synthesis is easy to perform. In this review the State of the Art will be presented, which includes a summary of the progress made over the past years in the knowledge of the structure and mechanism of the quinoxaline and quinoxaline derivatives, associated medical and biomedical value as well as industrial value. Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.ElsevierRepositório Científico do Instituto Politécnico do PortoAlmeida, JoanaPessoa, Ana M.Cordeiro, M. Natália D. S.Fernandes, RúbenPrudêncio, CristinaNoronha, João PauloVieira, Mónica2021-11-22T12:25:56Z2015-06-052015-06-05T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/18919engPereira, J. A., Pessoa, A. M., Cordeiro, M. N. D. S., Fernandes, R., Prudêncio, C., Noronha, J. P., & Vieira, M. (2015). Quinoxaline, its derivatives and applications: A State of the Art review. European Journal of Medicinal Chemistry, 97, 664-672. https://doi.org/https://doi.org/10.1016/j.ejmech.2014.06.0580223-523410.1016/j.ejmech.2014.06.058metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T13:12:10Zoai:recipp.ipp.pt:10400.22/18919Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:38:58.057292Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Quinoxaline, its derivatives and applications: A state of the art review
title Quinoxaline, its derivatives and applications: A state of the art review
spellingShingle Quinoxaline, its derivatives and applications: A state of the art review
Almeida, Joana
Quinoxaline
Quinoxaline derivatives
Biological activity
Therapeutic application
Biomedical applications
title_short Quinoxaline, its derivatives and applications: A state of the art review
title_full Quinoxaline, its derivatives and applications: A state of the art review
title_fullStr Quinoxaline, its derivatives and applications: A state of the art review
title_full_unstemmed Quinoxaline, its derivatives and applications: A state of the art review
title_sort Quinoxaline, its derivatives and applications: A state of the art review
author Almeida, Joana
author_facet Almeida, Joana
Pessoa, Ana M.
Cordeiro, M. Natália D. S.
Fernandes, Rúben
Prudêncio, Cristina
Noronha, João Paulo
Vieira, Mónica
author_role author
author2 Pessoa, Ana M.
Cordeiro, M. Natália D. S.
Fernandes, Rúben
Prudêncio, Cristina
Noronha, João Paulo
Vieira, Mónica
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico do Porto
dc.contributor.author.fl_str_mv Almeida, Joana
Pessoa, Ana M.
Cordeiro, M. Natália D. S.
Fernandes, Rúben
Prudêncio, Cristina
Noronha, João Paulo
Vieira, Mónica
dc.subject.por.fl_str_mv Quinoxaline
Quinoxaline derivatives
Biological activity
Therapeutic application
Biomedical applications
topic Quinoxaline
Quinoxaline derivatives
Biological activity
Therapeutic application
Biomedical applications
description Quinoxaline derivatives are an important class of heterocycle compounds, where N replaces some carbon atoms in the ring of naphthalene. Its molecular formula is C8H6N2, formed by the fusion of two aromatic rings, benzene and pyrazine. It is rare in natural state, but their synthesis is easy to perform. In this review the State of the Art will be presented, which includes a summary of the progress made over the past years in the knowledge of the structure and mechanism of the quinoxaline and quinoxaline derivatives, associated medical and biomedical value as well as industrial value. Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.
publishDate 2015
dc.date.none.fl_str_mv 2015-06-05
2015-06-05T00:00:00Z
2021-11-22T12:25:56Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.22/18919
url http://hdl.handle.net/10400.22/18919
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pereira, J. A., Pessoa, A. M., Cordeiro, M. N. D. S., Fernandes, R., Prudêncio, C., Noronha, J. P., & Vieira, M. (2015). Quinoxaline, its derivatives and applications: A State of the Art review. European Journal of Medicinal Chemistry, 97, 664-672. https://doi.org/https://doi.org/10.1016/j.ejmech.2014.06.058
0223-5234
10.1016/j.ejmech.2014.06.058
dc.rights.driver.fl_str_mv metadata only access
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rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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