The diagnosis and management of pre-invasive breast disease: genetic alterations in pre-invasive lesions

Detalhes bibliográficos
Autor(a) principal: Reis-Filho, Jorge S.
Data de Publicação: 2003
Outros Autores: Lakhani, Sunil R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/58478
Resumo: The development of modern molecular genetic techniques has allowed breast cancer researchers to clarify the multistep model of breast carcinogenesis. Laser capture microdissection coupled with comparative genomic hybridisation and/or loss-of-heterozygosity methods have confirmed that many pre-invasive lesions of the breast harbour chromosomal abnormalities at loci known to be altered in invasive breast carcinomas. Current data do not provide strong evidence for ductal hyperplasia of usual type as a precursor lesion, although some are monoclonal proliferations; however, atypical hyperplasia and in situ carcinoma appear to be nonobligate precursors. We review current knowledge and the contribution of molecular genetics in the understanding of breast cancer precursors and pre-invasive lesions.
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spelling The diagnosis and management of pre-invasive breast disease: genetic alterations in pre-invasive lesionsBreastBreast NeoplasmsCarcinoma in SituCarcinoma, Intraductal, NoninfiltratingChromosome AberrationsFemaleHumansHyperplasiaLoss of HeterozygosityNeoplasm Invasivenessatypical ductal hyperplasiacomparative genomic hybridisationductal carcinoma in situlobular carcinoma in situScience & TechnologyThe development of modern molecular genetic techniques has allowed breast cancer researchers to clarify the multistep model of breast carcinogenesis. Laser capture microdissection coupled with comparative genomic hybridisation and/or loss-of-heterozygosity methods have confirmed that many pre-invasive lesions of the breast harbour chromosomal abnormalities at loci known to be altered in invasive breast carcinomas. Current data do not provide strong evidence for ductal hyperplasia of usual type as a precursor lesion, although some are monoclonal proliferations; however, atypical hyperplasia and in situ carcinoma appear to be nonobligate precursors. We review current knowledge and the contribution of molecular genetics in the understanding of breast cancer precursors and pre-invasive lesions.JSRF is the recipient of the Gordon Signy International Fellowship Award of the World Association of Societies of Pathology and Laboratory Medicine (WASPALM) and is partially supported by a PhD grant (ref. SFRH/BD/5386/2001) from the Fundação para a Ciência e a Tecnologia (FCT), Portugal.info:eu-repo/semantics/publishedVersionBioMed Central (BMC)Universidade do MinhoReis-Filho, Jorge S.Lakhani, Sunil R.20032003-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/58478eng1465-54111465-542X10.1186/bcr65014580249info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:08:59Zoai:repositorium.sdum.uminho.pt:1822/58478Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:00:19.563976Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The diagnosis and management of pre-invasive breast disease: genetic alterations in pre-invasive lesions
title The diagnosis and management of pre-invasive breast disease: genetic alterations in pre-invasive lesions
spellingShingle The diagnosis and management of pre-invasive breast disease: genetic alterations in pre-invasive lesions
Reis-Filho, Jorge S.
Breast
Breast Neoplasms
Carcinoma in Situ
Carcinoma, Intraductal, Noninfiltrating
Chromosome Aberrations
Female
Humans
Hyperplasia
Loss of Heterozygosity
Neoplasm Invasiveness
atypical ductal hyperplasia
comparative genomic hybridisation
ductal carcinoma in situ
lobular carcinoma in situ
Science & Technology
title_short The diagnosis and management of pre-invasive breast disease: genetic alterations in pre-invasive lesions
title_full The diagnosis and management of pre-invasive breast disease: genetic alterations in pre-invasive lesions
title_fullStr The diagnosis and management of pre-invasive breast disease: genetic alterations in pre-invasive lesions
title_full_unstemmed The diagnosis and management of pre-invasive breast disease: genetic alterations in pre-invasive lesions
title_sort The diagnosis and management of pre-invasive breast disease: genetic alterations in pre-invasive lesions
author Reis-Filho, Jorge S.
author_facet Reis-Filho, Jorge S.
Lakhani, Sunil R.
author_role author
author2 Lakhani, Sunil R.
author2_role author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Reis-Filho, Jorge S.
Lakhani, Sunil R.
dc.subject.por.fl_str_mv Breast
Breast Neoplasms
Carcinoma in Situ
Carcinoma, Intraductal, Noninfiltrating
Chromosome Aberrations
Female
Humans
Hyperplasia
Loss of Heterozygosity
Neoplasm Invasiveness
atypical ductal hyperplasia
comparative genomic hybridisation
ductal carcinoma in situ
lobular carcinoma in situ
Science & Technology
topic Breast
Breast Neoplasms
Carcinoma in Situ
Carcinoma, Intraductal, Noninfiltrating
Chromosome Aberrations
Female
Humans
Hyperplasia
Loss of Heterozygosity
Neoplasm Invasiveness
atypical ductal hyperplasia
comparative genomic hybridisation
ductal carcinoma in situ
lobular carcinoma in situ
Science & Technology
description The development of modern molecular genetic techniques has allowed breast cancer researchers to clarify the multistep model of breast carcinogenesis. Laser capture microdissection coupled with comparative genomic hybridisation and/or loss-of-heterozygosity methods have confirmed that many pre-invasive lesions of the breast harbour chromosomal abnormalities at loci known to be altered in invasive breast carcinomas. Current data do not provide strong evidence for ductal hyperplasia of usual type as a precursor lesion, although some are monoclonal proliferations; however, atypical hyperplasia and in situ carcinoma appear to be nonobligate precursors. We review current knowledge and the contribution of molecular genetics in the understanding of breast cancer precursors and pre-invasive lesions.
publishDate 2003
dc.date.none.fl_str_mv 2003
2003-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/58478
url http://hdl.handle.net/1822/58478
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1465-5411
1465-542X
10.1186/bcr650
14580249
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BioMed Central (BMC)
publisher.none.fl_str_mv BioMed Central (BMC)
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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