Polymeric Nanofibers for Biomedical and Biotechnologic Applications
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | |
Tipo de documento: | Livro |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.6/4737 |
Resumo: | Bone tissue is a complex structure with the capacity to self-regenerate and responsible for different functions in our body. However, when bone integrity is disturbed, its self-regenerative capacity is lost. The available treatments are based on bone grafts and other bone substitutes which possess several limitations. Herein, a new approach to mimic the extracellular matrix of bone and cellular microenvironment was developed in this work. Therefore, an electrospinning apparatus was used to produce poly(ε-caprolactone), polyethylene oxide-sodium alginate and poly(vinyl)pirrolidone nanofibers. Subsequently, the same procedure was used for coating the alginate scaffold. In addition, poly(ε-caprolactone) electrospun nanofiber membranes were also produced and evaluated for phase separation applications. Membranes specific properties, such as pore size, fibers diameter and surface interactions were studied. The biological properties of the coated scaffolds were evaluated through in vitro cytotoxicity assays. The results showed that all the coated scaffolds had their biological performance improved. The membranes showed to be good candidates for phase separation area. |
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Polymeric Nanofibers for Biomedical and Biotechnologic ApplicationsNanofibersPolymersBone tissue is a complex structure with the capacity to self-regenerate and responsible for different functions in our body. However, when bone integrity is disturbed, its self-regenerative capacity is lost. The available treatments are based on bone grafts and other bone substitutes which possess several limitations. Herein, a new approach to mimic the extracellular matrix of bone and cellular microenvironment was developed in this work. Therefore, an electrospinning apparatus was used to produce poly(ε-caprolactone), polyethylene oxide-sodium alginate and poly(vinyl)pirrolidone nanofibers. Subsequently, the same procedure was used for coating the alginate scaffold. In addition, poly(ε-caprolactone) electrospun nanofiber membranes were also produced and evaluated for phase separation applications. Membranes specific properties, such as pore size, fibers diameter and surface interactions were studied. The biological properties of the coated scaffolds were evaluated through in vitro cytotoxicity assays. The results showed that all the coated scaffolds had their biological performance improved. The membranes showed to be good candidates for phase separation area.Lambert Academic PublishinguBibliorumCorreia, Tiago R.Correia, Ilídio Joaquim Sobreira2018-04-13T09:13:41Z20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bookapplication/pdfhttp://hdl.handle.net/10400.6/4737engCorreia, T.R. e Correia, I.J., (2014) “Polymeric Nanofibers for Biomedical and Biotechnologic Applications”, LAP LAMBERT Academic Publishing.978-3-659-59718-3metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-15T09:42:04Zoai:ubibliorum.ubi.pt:10400.6/4737Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:45:47.000364Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Polymeric Nanofibers for Biomedical and Biotechnologic Applications |
title |
Polymeric Nanofibers for Biomedical and Biotechnologic Applications |
spellingShingle |
Polymeric Nanofibers for Biomedical and Biotechnologic Applications Correia, Tiago R. Nanofibers Polymers |
title_short |
Polymeric Nanofibers for Biomedical and Biotechnologic Applications |
title_full |
Polymeric Nanofibers for Biomedical and Biotechnologic Applications |
title_fullStr |
Polymeric Nanofibers for Biomedical and Biotechnologic Applications |
title_full_unstemmed |
Polymeric Nanofibers for Biomedical and Biotechnologic Applications |
title_sort |
Polymeric Nanofibers for Biomedical and Biotechnologic Applications |
author |
Correia, Tiago R. |
author_facet |
Correia, Tiago R. Correia, Ilídio Joaquim Sobreira |
author_role |
author |
author2 |
Correia, Ilídio Joaquim Sobreira |
author2_role |
author |
dc.contributor.none.fl_str_mv |
uBibliorum |
dc.contributor.author.fl_str_mv |
Correia, Tiago R. Correia, Ilídio Joaquim Sobreira |
dc.subject.por.fl_str_mv |
Nanofibers Polymers |
topic |
Nanofibers Polymers |
description |
Bone tissue is a complex structure with the capacity to self-regenerate and responsible for different functions in our body. However, when bone integrity is disturbed, its self-regenerative capacity is lost. The available treatments are based on bone grafts and other bone substitutes which possess several limitations. Herein, a new approach to mimic the extracellular matrix of bone and cellular microenvironment was developed in this work. Therefore, an electrospinning apparatus was used to produce poly(ε-caprolactone), polyethylene oxide-sodium alginate and poly(vinyl)pirrolidone nanofibers. Subsequently, the same procedure was used for coating the alginate scaffold. In addition, poly(ε-caprolactone) electrospun nanofiber membranes were also produced and evaluated for phase separation applications. Membranes specific properties, such as pore size, fibers diameter and surface interactions were studied. The biological properties of the coated scaffolds were evaluated through in vitro cytotoxicity assays. The results showed that all the coated scaffolds had their biological performance improved. The membranes showed to be good candidates for phase separation area. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014 2014-01-01T00:00:00Z 2018-04-13T09:13:41Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/book |
format |
book |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.6/4737 |
url |
http://hdl.handle.net/10400.6/4737 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Correia, T.R. e Correia, I.J., (2014) “Polymeric Nanofibers for Biomedical and Biotechnologic Applications”, LAP LAMBERT Academic Publishing. 978-3-659-59718-3 |
dc.rights.driver.fl_str_mv |
metadata only access info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
metadata only access |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Lambert Academic Publishing |
publisher.none.fl_str_mv |
Lambert Academic Publishing |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799136355401334784 |