tRNAs as a driving force of genome evolution in yeast
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10773/34657 |
Resumo: | Transfer RNAs (tRNAs) are widely known for their roles in the decoding of the linear mRNA information into amino acid sequences of proteins. They are also multifunctional platforms in the translation process and have other roles beyond translation, including sensing amino acid abundance, interacting with the general stress response machinery, and modulating cellular adaptation, survival, and death. In this mini-review, we focus on the emerging role of tRNA genes in the organization and modification of the genomic architecture of yeast and the role of tRNA misexpression and decoding infidelity in genome stability, evolution, and adaption. We discuss published work showing how quickly tRNA genes can mutate to meet novel translational demands, how tRNAs speed up genome evolution, and how tRNA genes can be sites of genomic instability. We highlight recent works showing that loss of tRNA decoding fidelity and small alterations in tRNA expression have unexpected and profound impacts on genome stability. By dissecting these recent evidence, we hope to lay the groundwork that prompts future investigations on the mechanistic interplay between tRNAs and genome modification that likely triggers genome evolution. |
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tRNAs as a driving force of genome evolution in yeasttRNAChromatin structureYeastChromosome architectureGenome evolutionGenomic instabilityTransfer RNAs (tRNAs) are widely known for their roles in the decoding of the linear mRNA information into amino acid sequences of proteins. They are also multifunctional platforms in the translation process and have other roles beyond translation, including sensing amino acid abundance, interacting with the general stress response machinery, and modulating cellular adaptation, survival, and death. In this mini-review, we focus on the emerging role of tRNA genes in the organization and modification of the genomic architecture of yeast and the role of tRNA misexpression and decoding infidelity in genome stability, evolution, and adaption. We discuss published work showing how quickly tRNA genes can mutate to meet novel translational demands, how tRNAs speed up genome evolution, and how tRNA genes can be sites of genomic instability. We highlight recent works showing that loss of tRNA decoding fidelity and small alterations in tRNA expression have unexpected and profound impacts on genome stability. By dissecting these recent evidence, we hope to lay the groundwork that prompts future investigations on the mechanistic interplay between tRNAs and genome modification that likely triggers genome evolution.Frontiers Media S.A.2022-09-20T08:42:21Z2021-03-01T00:00:00Z2021-03info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/34657eng1664-302X10.3389/fmicb.2021.634004Guimarães, Ana RitaCorreia, InêsSousa, InêsOliveira, CarlaMoura, GabrielaBezerra, Ana RitaSantos, Manuel A.S.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T12:06:33Zoai:ria.ua.pt:10773/34657Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:05:46.696390Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
tRNAs as a driving force of genome evolution in yeast |
title |
tRNAs as a driving force of genome evolution in yeast |
spellingShingle |
tRNAs as a driving force of genome evolution in yeast Guimarães, Ana Rita tRNA Chromatin structure Yeast Chromosome architecture Genome evolution Genomic instability |
title_short |
tRNAs as a driving force of genome evolution in yeast |
title_full |
tRNAs as a driving force of genome evolution in yeast |
title_fullStr |
tRNAs as a driving force of genome evolution in yeast |
title_full_unstemmed |
tRNAs as a driving force of genome evolution in yeast |
title_sort |
tRNAs as a driving force of genome evolution in yeast |
author |
Guimarães, Ana Rita |
author_facet |
Guimarães, Ana Rita Correia, Inês Sousa, Inês Oliveira, Carla Moura, Gabriela Bezerra, Ana Rita Santos, Manuel A.S. |
author_role |
author |
author2 |
Correia, Inês Sousa, Inês Oliveira, Carla Moura, Gabriela Bezerra, Ana Rita Santos, Manuel A.S. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Guimarães, Ana Rita Correia, Inês Sousa, Inês Oliveira, Carla Moura, Gabriela Bezerra, Ana Rita Santos, Manuel A.S. |
dc.subject.por.fl_str_mv |
tRNA Chromatin structure Yeast Chromosome architecture Genome evolution Genomic instability |
topic |
tRNA Chromatin structure Yeast Chromosome architecture Genome evolution Genomic instability |
description |
Transfer RNAs (tRNAs) are widely known for their roles in the decoding of the linear mRNA information into amino acid sequences of proteins. They are also multifunctional platforms in the translation process and have other roles beyond translation, including sensing amino acid abundance, interacting with the general stress response machinery, and modulating cellular adaptation, survival, and death. In this mini-review, we focus on the emerging role of tRNA genes in the organization and modification of the genomic architecture of yeast and the role of tRNA misexpression and decoding infidelity in genome stability, evolution, and adaption. We discuss published work showing how quickly tRNA genes can mutate to meet novel translational demands, how tRNAs speed up genome evolution, and how tRNA genes can be sites of genomic instability. We highlight recent works showing that loss of tRNA decoding fidelity and small alterations in tRNA expression have unexpected and profound impacts on genome stability. By dissecting these recent evidence, we hope to lay the groundwork that prompts future investigations on the mechanistic interplay between tRNAs and genome modification that likely triggers genome evolution. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-03-01T00:00:00Z 2021-03 2022-09-20T08:42:21Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10773/34657 |
url |
http://hdl.handle.net/10773/34657 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1664-302X 10.3389/fmicb.2021.634004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers Media S.A. |
publisher.none.fl_str_mv |
Frontiers Media S.A. |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799137712616243200 |