Can host reaction animal models be used to predict and modulate skin regeneration?
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/44373 |
Resumo: | The study of host reactions in the biomedical and tissue engineering (TE) fields is a key issue but somehow set aside where TE constructs are concerned. Every day new biomaterials and TE constructs are being developed and presented to the scientific community. The combination of cells and biomolecules with scaffolding materials, as TE constructs, make the isolation and the understanding of the effect of each one those elements over the overall host reaction difficult. Eventually, all variables influence the host reaction and the performance of the constructs. For this reason, current assessment of the in vivo performance of TE constructs follows individual approaches, using specific animal models to independently provide insights regarding the contribution of the biomaterials/scaffolds towards the host reaction, and of all the constructs regarding their functionality. Skin wound healing progress into tissue regeneration or repair is highly dependent on the specificities of the inflammatory stage, as demonstrated by comparison between fetal and adult mechanisms. Thus, it would be expected that insights acquired from host tissue reaction evaluation to biomaterials/scaffolds would be explored to predict healing progression and improve the functionality of skin TE constructs. The rational of this review is to make a comprehensive analysis of to what extent the knowledge obtained from the evaluation of in vivo host reactions to implantable biomaterials/scaffolds has been used in the design of skin TE strategies, by promoting tissue regeneration rather than repair. |
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Can host reaction animal models be used to predict and modulate skin regeneration?Animal modelsBiomaterialsHost reactionImmune reactionInflammationScaffoldsSkin regenerationSkin tissue engineeringTissue engineeringScience & TechnologyThe study of host reactions in the biomedical and tissue engineering (TE) fields is a key issue but somehow set aside where TE constructs are concerned. Every day new biomaterials and TE constructs are being developed and presented to the scientific community. The combination of cells and biomolecules with scaffolding materials, as TE constructs, make the isolation and the understanding of the effect of each one those elements over the overall host reaction difficult. Eventually, all variables influence the host reaction and the performance of the constructs. For this reason, current assessment of the in vivo performance of TE constructs follows individual approaches, using specific animal models to independently provide insights regarding the contribution of the biomaterials/scaffolds towards the host reaction, and of all the constructs regarding their functionality. Skin wound healing progress into tissue regeneration or repair is highly dependent on the specificities of the inflammatory stage, as demonstrated by comparison between fetal and adult mechanisms. Thus, it would be expected that insights acquired from host tissue reaction evaluation to biomaterials/scaffolds would be explored to predict healing progression and improve the functionality of skin TE constructs. The rational of this review is to make a comprehensive analysis of to what extent the knowledge obtained from the evaluation of in vivo host reactions to implantable biomaterials/scaffolds has been used in the design of skin TE strategies, by promoting tissue regeneration rather than repair.T.C.S. acknowledges Grant No. RL3-TECT-NORTE-01-0124-FEDER-000020, co-financed by the North Portugal Regional Operational Programme (ON.2-O Novo Norte), under the National Strategic Reference Framework, through the European Regional Development Fund.WileyUniversidade do MinhoSantos, T. C.Reis, R. L.Marques, A. P.20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/44373engSantos T. C., Reis R. L., Marques A. P. Can host reaction animal models be used to predict and modulate skin regeneration?, Journal of Tissue Engineering and Regenerative Medicine, pp. N/A, doi:10.1002/term.2128, 20161932-700510.1002/term.2128http://dx.doi.org/10.1002/term.2128info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:19:35ZPortal AgregadorONG |
dc.title.none.fl_str_mv |
Can host reaction animal models be used to predict and modulate skin regeneration? |
title |
Can host reaction animal models be used to predict and modulate skin regeneration? |
spellingShingle |
Can host reaction animal models be used to predict and modulate skin regeneration? Santos, T. C. Animal models Biomaterials Host reaction Immune reaction Inflammation Scaffolds Skin regeneration Skin tissue engineering Tissue engineering Science & Technology |
title_short |
Can host reaction animal models be used to predict and modulate skin regeneration? |
title_full |
Can host reaction animal models be used to predict and modulate skin regeneration? |
title_fullStr |
Can host reaction animal models be used to predict and modulate skin regeneration? |
title_full_unstemmed |
Can host reaction animal models be used to predict and modulate skin regeneration? |
title_sort |
Can host reaction animal models be used to predict and modulate skin regeneration? |
author |
Santos, T. C. |
author_facet |
Santos, T. C. Reis, R. L. Marques, A. P. |
author_role |
author |
author2 |
Reis, R. L. Marques, A. P. |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Santos, T. C. Reis, R. L. Marques, A. P. |
dc.subject.por.fl_str_mv |
Animal models Biomaterials Host reaction Immune reaction Inflammation Scaffolds Skin regeneration Skin tissue engineering Tissue engineering Science & Technology |
topic |
Animal models Biomaterials Host reaction Immune reaction Inflammation Scaffolds Skin regeneration Skin tissue engineering Tissue engineering Science & Technology |
description |
The study of host reactions in the biomedical and tissue engineering (TE) fields is a key issue but somehow set aside where TE constructs are concerned. Every day new biomaterials and TE constructs are being developed and presented to the scientific community. The combination of cells and biomolecules with scaffolding materials, as TE constructs, make the isolation and the understanding of the effect of each one those elements over the overall host reaction difficult. Eventually, all variables influence the host reaction and the performance of the constructs. For this reason, current assessment of the in vivo performance of TE constructs follows individual approaches, using specific animal models to independently provide insights regarding the contribution of the biomaterials/scaffolds towards the host reaction, and of all the constructs regarding their functionality. Skin wound healing progress into tissue regeneration or repair is highly dependent on the specificities of the inflammatory stage, as demonstrated by comparison between fetal and adult mechanisms. Thus, it would be expected that insights acquired from host tissue reaction evaluation to biomaterials/scaffolds would be explored to predict healing progression and improve the functionality of skin TE constructs. The rational of this review is to make a comprehensive analysis of to what extent the knowledge obtained from the evaluation of in vivo host reactions to implantable biomaterials/scaffolds has been used in the design of skin TE strategies, by promoting tissue regeneration rather than repair. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 2017-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/44373 |
url |
http://hdl.handle.net/1822/44373 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Santos T. C., Reis R. L., Marques A. P. Can host reaction animal models be used to predict and modulate skin regeneration?, Journal of Tissue Engineering and Regenerative Medicine, pp. N/A, doi:10.1002/term.2128, 2016 1932-7005 10.1002/term.2128 http://dx.doi.org/10.1002/term.2128 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Wiley |
publisher.none.fl_str_mv |
Wiley |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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1777303730997166080 |